It reviews the framework for testing, assessing and managing the risks associated with chemicals, and for disseminating the related information. This includes provisions for chemical accident prevention, preparedness and response. The chapter also examines Colombia’s progress in managing specific chemicals, such as ozone-depleting substances, persistent organic pollutants and mercury, and reviews its participation in international co-operation in chemicals management. This fact underlines the importance of establishing a robust policy framework that ensures chemicals’ safe use throughout their life cycle.