While the use of those substances is increasingly affecting youth in the region, the limited data available prevent the accurate estimation of their market size, sources and trafficking routes. Seizures of “ecstasy”-type substances increased sharply in Brazil in 2014, with 877,853 tablets seized, an increase from 183,289 in 2013. In Colombia, seizures peaked in 2013, when 117,101 tablets were seized, increasing from 6,664 tablets in 2010, but seizures decreased again, to 39,792 tablets, in 2014. Guyana reported, as a new development, seizures of small quantities of “ecstasy” in the past two years. In 2014, Colombia reported four separate seizures of 4-bromo-2,5-dimethoxyphenethylamine (2C-B), amounting to 14,068 units in total.