For several years, large-scale trafficking in APAAN, a pre-precursor of amphetamine and methamphetamine, has been of concern to drug control authorities worldwide. In the European Union, following control measures implemented in member States from January 2014, both the number of seizures and the amounts of APAAN seized have decreased gradually from 34 seizures (a total of 28.7 tons) in 2012 to 9 seizures (8.1 tons) in 2014. In the first half of 2015, five incidents involving a total of 1,250 kg of the substance were reported. In December 2013, the European Union adopted new control measures aimed at preventing the large-scale diversion of acetic anhydride from the European Union market.