In order to mobilise them, medication adherence needs to be placed on the national policy agenda, starting with adherence being routinely observed and continuing towards the development of adherence quality and performance indicators. Such indicators could help in improving health system efficiency through establishing and influencing the relationship between the spending on pharmaceuticals and the gains in health outcomes. Improving how patients take their medicines requires that health professionals are equipped with skills specific to delivering care in a person-centred instead of the disease-centred model, i.e. that the providers should seek and gain understating of patients’ individual needs, perspectives, and values, convey to patients the information they need to participate in their care, and build trust and understanding. Avoidable costs in U.S. healthcare: The $200 billion opportunity from using medicines more responsibly.