The trafficking of persons around the world is a serious violation of human rights and manifestation of social injustice. It disproportionately affects women and children worldwide. Given the values of the social work profession and the prevalence of trafficking, it is essential to understand the current literature on human trafficking in social work journals. Using the PRISMA method, this systematic review (n = 94 articles) of human trafficking in social work journals found the following: more focus on sex trafficking than other forms of trafficking, a lack of a clear conceptualization and definition on the entire spectrum of trafficking, a lack of evidence-informed empirical research to inform programs, practice, and policy, and a dearth of recommendations for social work education. Specific implications for social work policy, research, practice, and education are highlighted and discussed.