There is of course a strong link between thematic and structural priorities, as the latter can improve the chances of success of the former. Structural priorities closely relate to discussions of “policy mixes”, which emphasise achieving an appropriate blend of measures. The globalisation of trade and investment, the international mobility of human resources, and the internationalisation of R&D and innovation, as well as the global rules-setting agenda in areas such as IPRs, redefine the space in which national STI policies and governance structures operate.