This book chapter systematizes and critically assesses the growing social rights jurisprudence of the Inter-American Commission on Human Rights as it has developed under its three case-based competences: (1) quasi-adjudication of individual complaints, (2) approval of friendly settlements, and (3) issuance of precautionary measures. It begins by addressing the Commission's subject matter jurisdiction over economic, social and cultural rights, the legal obligations that correspond to such rights under system-specific adjudicatory process, and the regional body's procedures for considering individual complaints of human rights violations. It then critically reviews the Commission's jurisprudential developments to date on the right to health, the right to education, the right to social security, the right to housing and land resources, the rights to work, labor guarantees, and freedom to unionize, and the right to culture, respectively, under each of the Commission's case-based competences.