AIDS has a uniquely political history. Its early association with stigmatised homosexual behaviour and more liberating gay identity activism set the precedent for highly effective mobilisation. The results were unparalleled in global health. AIDS was briefly treated as high politics and attracted increased funds to achieve the ambitious goal of universal access to HIV prevention and treatment. If AIDS is to maintain its visibility and contribution to global solidarity, human rights and dignity, its politics must evolve to reflect the profound geo-political, economic and social transformations currently underway. ‘Thinking politically about HIV’, an initiative of UNAIDS and the International AIDS Society, was convened in recognition of the need to better understand these politics and consider how the political sciences can further engage. This paper, and the edited volume it introduces, provides some insights into the Thinking Politically discussions as well as the wider scholarship on the challenges facin...