The opinions expressed and arguments employed herein do not necessarily reflect the official views of the Organisation or of the governments of its member countries. There is a strong movement in Antofagasta to ensure that the city is prepared for its future and can provide a higher quality of life for its residents. Yet the ability to manage the challenges ahead and engage in a vibrant process of transformation is constrained by public governance institutions and frameworks that are not adapted to Antofagasta’s dynamic context. This chapter explores some of Antofagasta’s governance challenges, particularly with respect to financial and human resources, to the development and implementation of a comprehensive strategic vision, and to the role of citizens and external stakeholders in public service delivery.