In several sub-Saharan African countries, girls of that age group are five times more likely to be infected than boys. By age 10 in Nepal, for example, many impoverished girls have been sold as slaves or as indentured servants through a process so normalized and formalized that it has its own name: kamalari (Plan International, 2010). The United Nations 2030 Agenda for Sustainable Development and its accompanying 17 Sustainable Development Goals provide an ambitious vision for global progress that does far more to position todays 10-year-old girls for a future course of health and happiness than any previous effort. It also contains specific targets to end child marriage and female genital mutilation, to ensure girls’ sexual and reproductive health and to achieve free, equitable and quality education. We have pledged to do this by 2030—when today’s 10-year-old girl will be 25.