This chapter reviews changes and continuities for the development of International Political Economy (IPE) in the twenty-first century. We highlight four themes, which authors in this handbook subsequently explore. These include necessary adaptations of IPE theory in response to changing global conditions, how global reordering affects global economic governance, production, and power relations, the diverse global crises to which actors must respond, often under intense time pressure, and a variety of emerging IPE issues on which we need new and/or more attention from IPE scholars and students. We conclude by identifying five trends which we argue would help enhance IPE understandings, ensure the policy relevance of our discipline, and prepare our students in the coming decade.