Deaths involving cocaine, amphetamine (including “ecstasy”) and NPS (most commonly mephedrone) also reached an all-time high. Similarly, 706 deaths related to drug misuse were registered in Scotland in 2015, which was 15 per cent higher than in 2014 and the largest number recorded since comparable records began, in 19967° Opioids (including heroin/morphine and methadone) were implicated in, or potentially contributed to, 606 of those deaths (86 per cent). Clinical Journal of Pain, vol.