Although in recent years some countries have made greater endeavours to place new psychoactive substances under national control, drug trafficking syndicates have responded and adapted by producing substances not yet under control, thus hindering drug control efforts. The abuse of keta-mine and its trafficking remain another area of concern for countries in the region. The total area of illicit opium poppy cultivation in the region was estimated to be 63,800 hectares (ha) in 2014, and production of opium estimated to be 762 tons. While the amount of illicit cultivation remains steady, a declining trend in the abuse of heroin in some East and South-East Asian countries has been reported.