The objective of this publication is to recount the experience of formulating and delivering the extracurricular seminar “Knowledge Production and HIV. A comprehensive approach”, developed during the year 2019 at the Faculty of Political Science and International Relations of the National University of Rosario (Argentina). We will then carry out a reconstruction of the theoretical, epistemological and pedagogical perspectives that we collectively constructed to elaborate this project that invites us to reflect on the need to re-situate the HIV/AIDS issue in the university environment from an integral and interdisciplinary perspective of human rights and public health.