combined treatment
The present data show, for the       first time, that the addition of cyclophosphamide to a pure antiestrogen used at        a maximal dose causes a more potent inhibition of human breast tumor growth, thus       suggesting that combined treatment using a maximal dose of a pure antiestrogen       and a chemotherapeutic agent(s), two classes of compounds having different       mechanisms of action, could further improve breast cancer therapy above the       results achieved with a potent and pure antiestrogen alone in estrogen-sensitive        breast cancer.
The present data show, for the       first time, that the addition of cyclophosphamide to a pure antiestrogen used at        a maximal dose causes a more potent inhibition of human breast tumor growth, thus       suggesting that  @SUBJECT$   @PREDICAT$  a maximal dose of a pure antiestrogen       and a  @OBJECT$ (s), two classes of compounds having different       mechanisms of action, could further improve breast cancer therapy above the       results achieved with a potent and pure antiestrogen alone in estrogen-sensitive        breast cancer.