drug
METHODS AND RESULTS: Sixty patients       were randomly assigned with a 2:1 ratio, drug versus placebo, administered with a       gradually increasing dose of 12.5 to 150 mg of blinded medication during an       8-week period and continued for 6 months.
METHODS AND RESULTS: Sixty patients       were randomly assigned with a 2:1 ratio,  @SUBJECT$   @PREDICAT$   @OBJECT$ , administered with a       gradually increasing dose of 12.5 to 150 mg of blinded medication during an       8-week period and continued for 6 months.