heart failure
METHODS: Fifty ambulatory patients, 18 to 75 years of age, with mild to        moderate heart failure, left ventricular ejection fraction </=35%, taking stable        doses of angiotensin-converting enzyme inhibitor, diuretics, and optionally       digoxin were enrolled in a randomized, double-blind, placebo-controlled       dose-escalation study of ecadotril 50 to 400 mg twice daily versus conventional       therapy alone.
METHODS: Fifty ambulatory  @OBJECT$ , 18 to 75 years of age,  @PREDICAT$  mild to        moderate  @SUBJECT$ , left ventricular ejection fraction </=35%, taking stable        doses of angiotensin-converting enzyme inhibitor, diuretics, and optionally       digoxin were enrolled in a randomized, double-blind, placebo-controlled       dose-escalation study of ecadotril 50 to 400 mg twice daily versus conventional       therapy alone.