DNA adducts
METHODS: Based on the finding that the progression of DNA/RNA polymerases on       templates might be blocked by bulky DNA adducts, we successfully developed and       used a polymerase stop assay to map the sites of adduct formation in the target       lacI gene following its reaction in vitro with alpha-acetoxytamoxifen and       horseradish peroxidase/H2O2 (HRP/H2O2) activated 4-hydroxytamoxifen.
METHODS: Based on the finding that the progression of DNA/ @OBJECT$  on       templates might be  @PREDICAT$  by bulky  @SUBJECT$ , we successfully developed and       used a polymerase stop assay to map the sites of adduct formation in the target       lacI gene following its reaction in vitro with alpha-acetoxytamoxifen and       horseradish peroxidase/H2O2 (HRP/H2O2) activated 4-hydroxytamoxifen.