rosiglitazone
Method The specific P450 enzymes involved        in the metabolism of rosiglitazone were determined by a combination of three       approaches; multiple regression analysis of the rates of metabolism of       rosiglitazone in human liver microsomes against selective P450 substrates, the       effect of selective chemical inhibitors on rosiglitazone metabolism and the       capability of expressed P450 enzymes to mediate the major metabolic routes of       rosiglitazone metabolism.
Method The specific P450 enzymes involved        in the metabolism of rosiglitazone were determined by a combination of three       approaches; multiple regression analysis of the rates of metabolism of        @SUBJECT$  in human liver microsomes against selective  @OBJECT$   @PREDICAT$ , the       effect of selective chemical inhibitors on rosiglitazone metabolism and the       capability of expressed P450 enzymes to mediate the major metabolic routes of       rosiglitazone metabolism.