emodin
Taken together, our results suggest that the tyrosine kinase       activity of HER-2/neu is required for tumor growth and chemoresistance and that       tyrosine kinase inhibitors such as emodin can inhibit the growth of       HER-2/neu-overexpressing tumors in mice and also sensitize these tumors to       paclitaxel.
Taken together, our results suggest that the tyrosine kinase       activity of HER-2/neu is required for tumor growth and chemoresistance and that       tyrosine kinase inhibitors such as  @SUBJECT$  can  @PREDICAT$  the  @OBJECT$  of       HER-2/neu-overexpressing tumors in mice and also sensitize these tumors to       paclitaxel.