tam
Incubation of tam with liver microsomes       from phenobarbital-treated rats, in the presence of 4-OH-A (10-100 microM),       resulted in marked inhibition of tam-N-demethylation and tam covalent binding and       in decreased tam-N-oxide accumulation; however, there was no inhibition of the       formation of 4-hydroxy-tam and of 3,4-dihydroxytamoxifen.
Incubation of  @SUBJECT$  with liver microsomes       from phenobarbital-treated rats, in the  @PREDICAT$  of  @OBJECT$ -A (10-100 microM),       resulted in marked inhibition of tam-N-demethylation and tam covalent binding and       in decreased tam-N-oxide accumulation; however, there was no inhibition of the       formation of 4-hydroxy-tam and of 3,4-dihydroxytamoxifen.