iNOS
To       examine the role of iNOS in the ischemic myocardium, we studied: 1) the time       course of expression of iNOS mRNA after myocardial infarction (MI) in male       Sprague-Dawley rat hearts and expression of iNOS protein in the infarcted region;       2) whether hypoxia in vitro is a potential mediator of the induction of iNOS       mRNA; and 3) whether inhibition of iNOS by two different selective inhibitors       (aminoguanidine and S-methylisothiourea sulfate) in vivo influences infarct size.
To       examine the  @PREDICAT$  of  @SUBJECT$  in the  @OBJECT$ , we studied: 1) the time       course of expression of iNOS mRNA after myocardial infarction (MI) in male       Sprague-Dawley rat hearts and expression of iNOS protein in the infarcted region;       2) whether hypoxia in vitro is a potential mediator of the induction of iNOS       mRNA; and 3) whether inhibition of iNOS by two different selective inhibitors       (aminoguanidine and S-methylisothiourea sulfate) in vivo influences infarct size.