sumatriptan
The discovery of the 5-HT1B/1D/1F agonist sumatriptan       constitutes a substantial advance in the acute treatment of migraine, though it       displays a number of nonnegligible shortcomings.
The discovery of the 5-HT1B/1D/1F agonist  @SUBJECT$        constitutes a substantial advance in the acute  @PREDICAT$  of  @OBJECT$ , though it       displays a number of nonnegligible shortcomings.