MC4-R
Subsequent development of the MC4-R knockout mouse model demonstrated       that MC4-R plays a role in weight homeostasis as these mice recapitulated the       metabolic defects of the agouti mouse.
Subsequent development of the MC4-R knockout mouse model demonstrated       that  @SUBJECT$  plays a  @PREDICAT$  in weight  @OBJECT$  as these mice recapitulated the       metabolic defects of the agouti mouse.