Earlier in the laboratory conditions not mimicking “real

Earlier studies have been shown an alteration in activity times, changes
happen in sleep period and feeding behavior together influence circadian
control of the endocrine system (16,17).

In our study, secretion pattern cortisol is similar to the circadian
ryhtem of cortisol seen in previous reports (3,12) with peak levels occurring
at early morning (06.00 p.m.) and sleep disruption had no significant effect on
this pattern. The results of Scheer et.al (2009) study showed, the cortisol secretion pattern is more influenced by the internal

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The study Fumihisa et al. (2013) showed that night
addition,  the concentration of
cortisol  in night shift did not differ
from that of the control group (19).  Also
in our study, the average concentration of cortisol
throughout 24 h  was not significantly
higher in the disrupted sleep group than the control group.

In agreement with
our study, a previous study,  did not show a significant circadian rhythm for
acylated ghrelin in  the normal subjects
that the nutritional state of the person is effective on ghrelin secretion
methodological differences that prevented comparison  this study with other works.

1- the number of blood sampling: In our
works were between 24-72  during 24 hours

2- Age and sex. Most previous studies
a very large age range (13,21).

3-sleep and sleep
or nocturnal pattern of ghrelin secretion investigated in the laboratory
conditions not mimicking “real life.

In conclusion, Sleep deprivation has no significant
effect on the diurnal pattern of cortisol. In addition, ghrelin does not show a
circadian rhythm.


The small number of subjects and low
number sampling over 24 h are limitations.


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