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Murine bone marrow-derived mast cells (BMMCs) transduced with pAPM lentiviruses overexpressing miR-221 vs control overexpressing miR-221m.

ABSTRACT: Bone marrow-derived mast cells were derived from three different female C57Bl/6 mice of similar age. Cells were transduced with pAPM lentiviruses either overexpressing microRNA-221 or a non functional microRNA-221 mutant, termed miR-221m, where four point-mutations were introduced in the seed sequence of miR-221. The samples overexpressing miR-221m were used as references for the corresponding miR-221 overexpressing BMMCs from the same mouse (mouse matched reference). The experiment was performed in order to gain more insights about the molecular mechanisms underlying miR-221 effects in mast cells. Two-condition experiment, BMMC overexpressing miR-221 vs BMMC overexpressing miR-221m. Biological replicates: 3 replicates overexpressing miR-221, 3 control replicates overexpressing miR-221m.

ORGANISM(S): Mus musculus  

SUBMITTER: Silvia Monticelli   Ramon J Mayoral 

PROVIDER: E-GEOD-24462 | ArrayExpress | 2011-11-23



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Mayoral Ramon J RJ   Deho Lorenzo L   Rusca Nicole N   Bartonicek Nenad N   Saini Harpreet Kaur HK   Enright Anton J AJ   Monticelli Silvia S  

PloS one 20111012 10


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