




Gene Review

STK17B  -  serine/threonine kinase 17b

Homo sapiens

Synonyms: DAP kinase-related apoptosis-inducing protein kinase 2, DRAK2, Serine/threonine-protein kinase 17B

Disease relevance of STK17B


High impact information on STK17B


Associations of STK17B with chemical compounds


Anatomical context of STK17B

  • CHP and rat DRAK2 expressed in COS-7 cells were found to be localized in the Golgi apparatus and nucleus, respectively [1].
  • The intracellular location of DRAK2 depended on the cell line: DRAK2 was found primarily in the nuclei of NRK, NIH3T3, and Caco-2 cells while it was present primarily in the cytoplasm of ACL-15, HeLa, and WI-38 cells [5].

Regulatory relationships of STK17B


Other interactions of STK17B

  • DRAK1 and DRAK2 show 59.7% identity and display ubiquitous expression [3].


  1. A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. Matsumoto, M., Miyake, Y., Nagita, M., Inoue, H., Shitakubo, D., Takemoto, K., Ohtsuka, C., Murakami, H., Nakamura, N., Kanazawa, H. J. Biochem. (2001) [Pubmed]
  2. Transgenic drak2 overexpression in mice leads to increased T cell apoptosis and compromised memory T cell development. Mao, J., Qiao, X., Luo, H., Wu, J. J. Biol. Chem. (2006) [Pubmed]
  3. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. Sanjo, H., Kawai, T., Akira, S. J. Biol. Chem. (1998) [Pubmed]
  4. Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. Friedrich, M.L., Cui, M., Hernandez, J.B., Weist, B.M., Andersen, H.M., Zhang, X., Huang, L., Walsh, C.M. J. Biol. Chem. (2007) [Pubmed]
  5. Nuclear localization of the serine/threonine kinase DRAK2 is involved in UV-induced apoptosis. Kuwahara, H., Nakamura, N., Kanazawa, H. Biol. Pharm. Bull. (2006) [Pubmed]
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