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With advances in medicine over the past few decades, namely recombinant DNA technology, human insulin can now be manufactured or synthesized. Some patients may require one injection daily; other patients may require two to four injections daily. If your thyroid is still healthy, it'll reset and get back to normal function within a couple of week after getting off of T3. Insulin is also involved in the processes that break down carbohydrates, fats, and proteins received from the diet into substances the body can use.
Synthetic human insulin is identical to natural insulin that is made in human body and is now the most common form of insulin used.Various formulations of injectable human insulin are available including regular insulin (R), isophane insulin (NPH), lente insulin (L), and ultralente insulin (U). For specific information on how the drugs interact and the severity of the interaction, please use our Drug Interactions Checker. To decrease the number of injections for those individuals who require more than one kind of insulin, insulins have also been combined into one product. Insulin lispro is recommended to be given 15 minutes before or immediately after a meal whereas insulin aspart should generally be given immediately before a meal (start of meal within 5 to 10 minutes after injection). These forms of insulin were created in hopes to lessen side effects, improve effectiveness, and have differing onsets, peaks, and duration of activity over the previous human insulin formulations. To see how the various insulins compare with regard to their onset of blood sugar-lowering activity, their peak time of effect, and their duration of effect on blood sugar-lowering, please see the table directly below.In addition to injectable forms of insulin, in 2006, an inhalable form of insulin (Exubera) was FDA-approved for us. However, in October 2007, the maker of Exubera announced that it will no longer make the inhaled insulin available for patients.
This decision was based on lower than expected sales of the product and was not due to any safety concerns.Since the different types of insulin vary in onset of action, time to peak effect, and duration of action, your doctor will decide what type of insulin is best for you. Humulin is the only available brand of ultralente insulin.Clinical studies have compared insulin aspart (NovoLog) and insulin lispro (Humalog), and insulin glulisine (Apidra) to regular insulin (R), and they were found to have similar effectiveness to regular insulin (R). However, insulin aspart (NovoLog) and insulin lispro (Humalog) may be associated with fewer low blood sugar episodes (called hypoglycemia) than regular insulin (R).

Additionally, insulin lispro (Humalog) may offer more flexibility than regular insulin (R) in regards to timing the dose with meals.
Insulin aspart (NovoLog), insulin lispro (Humalog) and insulin glulisine (Apidra) appear to be similarly effective.Insulin glargine (Lantus) was compared to NPH insulin in clinical trials, and no differences were seen in overall effectiveness. However, fewer low blood sugar episodes (especially nighttime episodes) were seen with insulin glargine (Lantus).
There are no published clinical trial results comparing insulin glargine (Lantus) to ultralente insulin (U).
Pharmacokinetics, prandial glucose control, and safety of insulin glulisine in children and adolescents with type 1 diabetes. Comparison of insulin aspart with buffered regular insulin and insulin lispro in continuous subcutaneous insulin infusion: a randomized study in type 1 diabetes. Use of insulin aspart, a fast-acting insulin analog, as the mealtime insulin in the management of patients with type 1 diabetes. Mealtime treatment with insulin analog improves postprandial hyperglycemia and hypoglycemia in patients with non-insulin-dependent diabetes mellitus. Direct comparison of insulin lispro and aspart shows small differences in plasma insulin profiles after subcutaneous injection in Type 1 diabetes. Safety of insulin glulisine compared with insulin aspart administered by continuous subcutaneous insulin infusion (CSII) [abstract 15-OR]. Basal insulin glargine (HOE 901) versus NPH insulin in patients with Type 1 diabetes on multiple daily insulin regimens.
A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in patients with Type 1 diabetes. Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in Type 2 Diabetes.
Safety and efficacy of insulin glargine (HOE 901) versus NPH insulin in combination with oral treatment in type 2 diabetic patients.

A one-year, randomized, multicenter trial comparing insulin glargine with NPH insulin in combination with oral agents in patients with type 2 diabetes. Once-daily insulin glargine compared with twice-daily NPH insulin in patients with type 1 diabetes. The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. A randomized multicenter trial of insulin glargine compared with NPH insulin in people with type 1 diabetes. A comparison of bedtime insulin glargine with bedtime neutral protamine hagedorn insulin in patients with type 2 diabetes: subgroup analysis of patients taking once-daily insulin in a multicenter, randomized, parallel group study.
Intensive replacement of basal insulin in patients with type 1 diabetes given rapid-acting insulin analog at mealtime: a 3-month comparison between administration of NPH insulin four times daily and glargine insulin at dinner or bedtime. Better long-term glycemic control with the basal insulin glargine as compared with NPH in patients with Type 1 diabetes mellitus given meal-time lispro insulin. Glargine is superior to neutral protamine Hagedorn for improving glycated haemoglobin and fasting blood glucose levels during intensive insulin therapy. Twice-daily pre-mixed insulin rather than basal insulin therapy alone results in better overall glycemic control in patients with type 2 diabetes. Initiating insulin therapy in type 2 diabetes: a comparison of biphasic and basal insulin analogs. Insulin detemir plus insulin aspart is associated with less risk of major as well as nocturnal hypoglycemia than insulin glargine plus insulin aspart at comparable levels of glycaemic control in type 1 diabetes [abstract 242].

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