TY - JOUR T1 - Hormone therapy in menopausal women with cognitive complaints JF - Neurology JO - Neurology SP - 1322 LP - 1330 DO - 10.1212/01.wnl.0000277275.42504.93 VL - 69 IS - 13 AU - Maki, P. M. AU - Gast, M. J. AU - Vieweg, A. J. AU - Burriss, S. W. AU - Yaffe, K. Y1 - 2007/09/25 UR - http://n.neurology.org/content/69/13/1322.abstract N2 - Objective: To evaluate the effects of hormone therapy (HT) on cognition and subjective quality of life (QoL) in recently postmenopausal women with cognitive complaints. Methods: Cognitive Complaints in Early Menopause Trial (COGENT) was a randomized, double-blind, placebo-controlled, multicenter, pilot study of 180 healthy postmenopausal women aged 45 to 55 years, randomly assigned to receive either placebo or conjugated equine estrogen 0.625 mg/medroxyprogesterone acetate 2.5 mg for 4 months. Outcome measures included memory, subjective cognition, QoL, sexuality, and sleep, which were assessed at baseline and month 4. Results: The study was terminated before the expected final sample size of 275 due to a decrease in enrollment coinciding with the publication of findings from the Women’s Health Initiative. There were no differences between groups on any cognitive or QoL measures, except for an increase in sexual interest and thoughts with HT. Modest negative effects on short- and long-term verbal memory approached significance (p &lt; 0.10). Women with baseline vasomotor symptoms (VMS) showed a decrease in VMS and an improvement in general QoL, but no cognitive benefit vs placebo. Conclusions: With the power to detect an effect size of ≥0.45, this study suggests potential modest negative effects on verbal memory that are consistent with previous hormone therapy trials in older women. GLOSSARY: BTA = Brief Test of Attention; BVRT = Benton Visual Retention Test; COGENT = Cognitive Complaints in Early Menopause Trial; CRT = Educational Testing Service Card Rotation Test; CVLT = California Verbal Learning; FAS = Letter Fluency Test; HERS = Heart and Estrogen/progestin Replacement Study; HT = hormone therapy; MFSQ = McCoy Female Sexuality Scale Questionnaire; MFQ = The Memory Functioning Questionnaire; PANAS = Positive and Negative Affect Scale; PSQI = The Pittsburgh Sleep Quality Index; QoL = subjective quality of life; SWAN = Study of Women’s Health Across the Nation; UQoL = Utian Quality of Life; VMS = vasomotor symptoms Test; WHI = Women’s Health Initiative; WHISCA = WHI Study of Cognitive Aging; WMS-R/DGT-F, MS-R/DGT-B = Digit Span Forward and Backward Subtests of the Wechsler Memory Scale–Revised. ER -