Pronunciation: LIX i SEN a tide

Brand: Adlyxin

What is the most important information I should know about lixisenatide?


What is lixisenatide?


Lixisenatide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Lixisenatide is not for treating type 1 diabetes.

Lixisenatide may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using lixisenatide?

You should not use lixisenatide if you are allergic to it.

To make sure lixisenatide is safe for you, tell your doctor if you have:

  • a history of pancreatitis or gall stones;
  • problems with digestion;
  • kidney disease;
  • a history of alcoholism; or


Lixisenatide can make birth control pills less effective. Ask your doctor about using a nonhormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

Lixisenatide is not approved for use by anyone younger than 18 years old.

How should I use lixisenatide?



Lixisenatide comes in a prefilled injection pen that contains 14 pre-set doses. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Lixisenatide is usually injected once per day. Use lixisenatide within 60 minutes (1 hour) before your first meal of the day. Try to use the medicine at the same time each day.

Your care provider will show you the best places on your body to inject lixisenatide. Use a different place each time you give an injection. Do not inject into the same place two times in a row.






Use a disposable needle only once. Follow any state or local laws about throwing away used needles. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.


Storing unopened (not in use) lixisenatide: Refrigerate and protect from light. Take the injection pen out of the refrigerator and allow it to reach room temperature before using.

Do not freeze lixisenatide, and throw away the medicine if it has been frozen.

Storing opened (in use) lixisenatide: Store at room temperature with the pen cap attached, and use within 14 days. Do not store the injection pen with a needle attached.

What happens if I miss a dose?

Wait until your next meal and use the medicine within 1 hour before you eat. Then go back to your regular injection schedule the next day. Do not use extra medicine to make up the missed dose.

What happens if I overdose?


What should I avoid while using lixisenatide?


  • If you also take acetaminophen (Tylenol), take it at least 1 hour before you use lixisenatide.
  • If you also take any type of antibiotic, take it at least 1 hour before you use lixisenatide.
  • If you also take a birth control pill, take it at least 1 hour before or 11 hours after you use lixisenatide.

What are the possible side effects of lixisenatide?

Get emergency medical help if you have signs of an allergic reaction: hives, itching, severe rash; rapid heartbeats; trouble swallowing; difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.



Common side effects may include:

  • nausea, vomiting, diarrhea;
  • headache;
  • dizziness; or
  • low blood sugar.


What other drugs will affect lixisenatide?


Where can I get more information?

Your pharmacist can provide more information about lixisenatide.



