TY - JOUR T1 - Characterization of Conditionally Expressed Mutants Affecting Age-Specific Survival in Inbred Lines of <em>Drosophila melanogaster</em> JF - Genetics JO - Genetics SP - 1241 LP - 1248 DO - 10.1534/genetics.103.023721 VL - 167 IS - 3 AU - Vermeulen, C. J. AU - Bijlsma, R. Y1 - 2004/07/01 UR - http://www.genetics.org/content/167/3/1241.abstract N2 - The specific genetic basis of inbreeding depression is poorly understood. To address this question, two conditionally expressed lethal effects that were found to cause line-specific life span reductions in two separate inbred lines of Drosophila melanogaster were characterized phenotypically and genetically in terms of whether the accelerated mortality effects are dominant or recessive. The mortality effect in one line (I4) is potentially a temperature-sensitive semilethal that expresses in adult males only and is partially dominant. The other line (I10) responds as one would expect for a recessive lethal. It requires a cold shock for expression and is cold sensitive. Flies exhibiting this lethal condition responded as pupae and freshly eclosed imagoes. The effect is recessive in both males and females. The expression of the lethal effects in both lines is highly dependent upon environmental conditions. These results will serve as a basis for more detailed and mechanistic genetic research on inbreeding depression and are relevant to sex- and environment-specific effects on life span observed in quantitative trait loci studies using inbred lines. ER -