14  structures 402  species 42477  sequences

Family: Metazoa_SRP (RF00017)

Description: Metazoan signal recognition particle RNA



This family is a member of clan (CL00003), which contains the following 8 members:

Archaea_SRP Bacteria_large_SRP Bacteria_small_SRP Dictyostelium_SRP Fungi_SRP Metazoa_SRP Plant_SRP Protozoa_SRP

Wikipedia annotation Edit Wikipedia article

The Rfam group coordinates the annotation of Rfam families in Wikipedia. This family is described by a Wikipedia entry Signal recognition particle RNA. More...





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Secondary structure



Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence



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For those sequences which have a structure in the Protein DataBank, we generate a mapping between EMBL, PDB and Rfam coordinate systems. The table below shows the structures on which the Metazoa_SRP family has been found.

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Motif matches

There are 5 motifs which match this family.


7 RM00005 CsrA/RsmA binding motif 44 0.484 412.3 Match Image
7 RM00008 GNRA tetraloop 71 0.780 1144.2 Match Image
7 RM00010 Kink turn 1, 3' bulge 35 0.385 367.0 Match Image
7 RM00020 Signal recognition particle small S-domain 91 1.000 4302.3 Match Image
7 RM00024 T-loop 11 0.121 109.1 Match Image



Literature references

  1. Wild K, Weichenrieder O, Strub K, Sinning I, Cusack S Curr Opin Struct Biol 2002;12:72-81. Towards the structure of the mammalian signal recognition particle. PUBMED:11839493

  2. Batey RT, Rambo RP, Lucast L, Rha B, Doudna JA Science 2000;287:1232-1239. Crystal structure of the ribonucleoprotein core of the signal recognition particle. PUBMED:10678824

  3. Batey RT, Sagar MB, Doudna JA J Mol Biol 2001;307:229-246. Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle. PUBMED:11243816

  4. Rosenblad MA, Gorodkin J, Knudsen B, Zwieb C, Samuelsson T Nucleic Acids Res 2003;31:363-364. SRPDB: Signal Recognition Particle Database. PUBMED:12520023

  5. Regalia M, Rosenblad MA, Samuelsson T Nucleic Acids Res 2002;30:3368-3377. Prediction of signal recognition particle RNA genes. PUBMED:12140321

  6. Rosenblad MA, Larsen N, Samuelsson T, Zwieb C RNA Biol. 2009;6:508-516. Kinship in the SRP RNA family. PUBMED:19838050

External database links

Curation and family details



Seed source Published; PMID:19838050
Structure source Published; PMID:19838050
Type Gene;
Author Gardner PPORCID logo
Alignment details
Alignment Number of
full 42,386
seed 91

Model information

Build commands
cmbuild -F CM SEED
cmcalibrate --mpi CM
Search command
cmsearch --cpu 4 --verbose --nohmmonly -T 19.49 -Z 549862.597050 CM SEQDB
Gathering cutoff 70.0
Trusted cutoff 70.0
Noise cutoff 69.9
Covariance model Download