Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

FASN (P49327) - Overview - Molecular Target Synopsis


FASN, Fatty acid synthase
Enzyme Classification
UniProt P49327

Also Known as FAS_HUMAN, FASN, FAS

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. Homodimer which is arranged in a head to tail fashion (PubMed:17618296, PubMed:18022563, Ref.28). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: FASN is active in the following subcellular-locations: cytoplasm, melanosome.
GO terms: FASN is active in the following subcellular-locations: cytosol, extracellular exosome, glycogen granule, Golgi apparatus, melanosome, membrane, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project FASN has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, MALME_3M, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-175-VII, HCC2688, YMB-1-E

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HMEC

(see details)

3D Structures

For FASN there are:
13 structures (32 chains) solved
7 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

FASN has been screened with 679 compounds (734 bioactivities), 348 compounds have bioactivities that show binding affinity of <= 500nM (369 bioactivities). (see details)