Native from Talhovi, House Mekuun was one of the Ancient Houses that originally settled the Senex-Juvex region. House Mekuun's holdings were in the Juvex sector. At the end of the sector's Crimson Days, the House dissolved itself, and sought to reconstitute itself as a sector of the Galactic Republic.

The Mekuun family apparently owned the Mekuun Corporation. It was allied with Roganda Ismaren's plot in 12 ABY.