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Nail Patella Syndrome Worldwide is the official organization of the NPS Community.



What is NPS?
Nail Patella Syndrome (also called Fong's Disease, Hereditary Onycho-Osteodysplasia ['HOOD'] is characterized by several typical abnormalities of the arms and legs as well as kidney disease and glaucoma. It has been recognized as a hereditary condition for over 100 years and is inherited in an autosomal dominant manner. That is, the risk of transmission is 50% per pregnancy, irrespective of gender (just like flipping a coin). Approximately 20% of cases are sporadic, being the result of a new mutation. The incidence is approximately 1 in 50,000 and occurs throughout the world in all ethnic groups.