
F1000Prime Rep January 1, 2013; 5 47.

Control of gene expression by CRISPR-Cas systems.

Bikard D , Marraffini LA .

Clustered regularly interspaced short palindromic repeats (CRISPR) loci and their associated cas (CRISPR-associated) genes provide adaptive immunity against viruses (phages) and other mobile genetic elements in bacteria and archaea. While most of the early work has largely been dominated by examples of CRISPR-Cas systems directing the cleavage of phage or plasmid DNA, recent studies have revealed a more complex landscape where CRISPR-Cas loci might be involved in gene regulation. In this review, we summarize the role of these loci in the regulation of gene expression as well as the recent development of synthetic gene regulation using engineered CRISPR-Cas systems.

PubMed ID: 24273648
PMC ID: PMC3816762
Article link: F1000Prime Rep

Genes referenced: pam

Article Images: [+] show captions
References [+] :
Aklujkar, Interference with histidyl-tRNA synthetase by a CRISPR spacer sequence as a factor in the evolution of Pelobacter carbinolicus. 2010, Pubmed

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