nuclear factor-kappaB

nuclear factor-κB

an evolutionarily conserved eukaryotic transcription factor system that contributes to the mounting of an effective immune response but also plays an important role in many other cellular processes. NF-κB and its regulators are linked to signal transduction pathways as well as transcriptional activation events that mediate critical stages of cell proliferation, development, and apoptosis.

nu·cle·ar fac·tor-κB

(nū'klē-ăr fak'tŏr)
A transcription factor associated with cytokine production.
References in periodicals archive ?
In addition, some expression is also found in pancreatic islet cells, pituitary gland and hypothalamus.2 In T2DM, serum resistin levels are higher compared to healthy persons.3,4 Raised serum resistin levels lead to inhibition of insulin, signalling by activation of suppressor of cytokine signaling-3(SOCS-3) pathway, up-regulation of phosphatase and tensin homolog protein (PTEN) gene and activation of nuclear factor-kappaB (NF-kB) pathway.3
Conclusions: Estrogen can promote the apoptosis and proliferation of osteoblasts simultaneously, and the mechanism may be the joint action of transforming growth factor-beta, Wnt, mitogen-activated protein kinase, and nuclear factor-kappaB bone metabolism-related signaling pathway.
Nuclear factor-kappaB in cancer development and progression.
Previously, we have established an organ culture model and demonstrated that organ culture of rat renal artery segments induced activation of nuclear factor-kappaB (NF-[kappa]B) signaling transduction pathway and subsequently upregulated endothelin type A ([ET.sub.A]) and type B ([ET.sub.B]) receptors in the smooth muscle cells [12].
Karin, "Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases," The New England Journal of Medicine, vol.
Analysis of samples began with quantitative real time polymerase chain reaction (qRT-PCR) of CD34, hypoxia inducible factor 1 alpha (HIF-1a), nuclear factor-kappaB (NF-kB), and vascular endothelial growth factor (VEGF) using primers for each gene, while glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as a housekeeping gene control.
found that potassium iodide ameliorated renal ultrastructure and degraded expression of nuclear factor-kappaB and fibronectin induced by lead [19].

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