

This is a Eyes condition.

Golden Retriever Progressive Retinal Atrophy 1, GR-PRA1

What is GR-PRA1?

This retinal disease causes progressive, non-painful vision loss. The retina contains the cells, photoreceptors, that collect information about light: that is, they are the very beginning of how we see. There are two types of photoreceptors: rods, which gather information about light intensity and are the major contributors to night vision, and cones, which distinguish color and are the major contributors to day vision. In nearly all forms of PRA, the rod cells are affected first, leading to night blindness. They are followed by the cone cells, leading to day blindness. The mechanisms by which the photoreceptors degenerate vary depending on the specific mutation that causes PRA. However, the readout is the same: the dog experiences a slow loss of vision, often leading to complete blindness. PRA is a subtle disease: most owners do not even know that their dog has gone blind--you may notice that your dog is reluctant to go down the stairs, or bumping into door frames or corners, or taking a very long time to fetch a ball or toy. A peek at your dog’s eyes in bright light may also reveal a sluggish pupillary constriction, because the retina is no longer telling your pupils that it is letting in too much light; however, definitive diagnosis of PRA requires a trip to the vet. Because of the slow progression of PRA, most dogs adapt very well to their condition. Over time, affected dogs can develop cataracts, thought to be due to buildup of reactive oxygen species and other toxic metabolites released from the degenerating retinal cells. This can lead to other complications and requires close monitoring in consultation with your vet.

What are the signs & symptoms that develop in affected dogs?

PRA is a subtle disease and dogs adapt very well to the slow loss of vision. You may notice that your dog is reluctant to go down the stairs, bumps into door frames or corners, or takes a longer time to fetch a toy.

When do signs and symptoms develop?

This is a late onset form of PRA with first signs appearing between 6 to 7 years of age.

How do vets diagnose this condition?


How is this condition treated?


What actions should I take if my dog is affected?

Careful monitoring by your veterinarian will be required for the rest of your affected dog's life as secondary complications, including cataracts, can develop. With blind dogs, keeping furniture in the same location, making sure they are on a leash in unfamiliar territory, and training them to understand verbal commands are some of the ways to help them at home.

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