ATP5J Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes. Belongs to the eukaryotic ATPase subunit F6 family. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - oxidative phosphorylation; Mitochondrial
Chromosomal Location of Human Ortholog: 16|16 C3.3
Cellular Component:  cell surface; extracellular space; membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); mitochondrion; proton-transporting ATP synthase complex, coupling factor F(o)
Molecular Function:  protein-containing complex binding; proton transmembrane transporter activity
Biological Process:  ATP metabolic process; ATP synthesis coupled proton transport; ion transport; negative regulation of arachidonic acid secretion; negative regulation of prostaglandin secretion; positive regulation of blood pressure; positive regulation of heart rate
Reference #:  P97450 (UniProtKB)
Alt. Names/Synonyms: ATP synthase coupling factor VI; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F; ATP synthase-coupling factor 6, mitochondrial; Atp5j; ATPase subunit F6; mitochondrial ATP synthase coupling factor 6; OTTMUSP00000030445; OTTMUSP00000030446; OTTMUSP00000030603
Gene Symbols: Atp5j
Molecular weight: 12,496 Da
Basal Isoelectric point: 9.36  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene