Gene Symbol: Slk
Description: STE20-like kinase
Alias: Stk2, STE20-like serine/threonine-protein kinase, STE20-related kinase, STE20-related serine/threonine-protein kinase, serine/threonine kinase 2
Species: rat
Products:     Slk

Top Publications

  1. Cybulsky A, Takano T, Papillon J, Khadir A, Bijian K, Chien C, et al. Renal expression and activity of the germinal center kinase SK2. Am J Physiol Renal Physiol. 2004;286:F16-25 pubmed
    ..of a protein kinase consistent with SK2, a group II germinal center kinase and homolog of human Ste20-like kinase (SLK)...
  2. Burakov A, Zhapparova O, Kovalenko O, Zinovkina L, Potekhina E, Shanina N, et al. Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase. Mol Biol Cell. 2008;19:1952-61 pubmed publisher
    ..Ste20-like protein kinase LOSK (SLK) was identified as a microtubule and centrosome-associated protein...
  3. Yun H, Yoon J, Lee J, Noh K, Yoon K, Oh S, et al. Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. EMBO J. 2011;30:2465-76 pubmed publisher
    ..Our results thus highlight new functions of Daxx and MST1 that they are the key mediators of microglial cell death initiated by the proinflammatory cytokine IFN-?. ..
  4. Luhovy A, Jaberi A, Papillon J, Guillemette J, Cybulsky A. Regulation of the Ste20-like kinase, SLK: involvement of activation segment phosphorylation. J Biol Chem. 2012;287:5446-58 pubmed publisher
    Expression and activation of the Ste20-like kinase, SLK, is increased during kidney development and recovery from ischemic acute kidney injury. SLK promotes apoptosis, and it may regulate cell survival during injury or repair...
  5. Quizi J, Baron K, Al Zahrani K, O REILLY P, Sriram R, Conway J, et al. SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration. Oncogene. 2013;32:4656-63 pubmed publisher
    ..We have previously shown that the Ste20-like kinase (SLK) is required for cell migration and efficient focal adhesion (FA) turnover in a FA kinase (FAK)-dependent manner...
  6. Jaberi A, Hooker E, Guillemette J, Papillon J, Kristof A, Cybulsky A. Identification of Tpr and Î±-actinin-4 as two novel SLK-interacting proteins. Biochim Biophys Acta. 2015;1853:2539-52 pubmed publisher
    Expression and activity of the Ste20-like kinase, SLK, are increased during kidney development and recovery from ischemia-reperfusion injury...
  7. Yue C. Novel putative protein kinase clones from a rat large granular lymphocyte tumor cell line. Mol Immunol. 1991;28:399-408 pubmed
  8. Vitt U, Gietzen D, Stevens K, Wingrove J, Becha S, Bulloch S, et al. Identification of candidate disease genes by EST alignments, synteny, and expression and verification of Ensembl genes on rat chromosome 1q43-54. Genome Res. 2004;14:640-50 pubmed
    ..The combination of the results from these different analyses represents a powerful approach for narrowing the number of genes that could play a role in the development of complex diseases. ..
  9. Pike A, Rellos P, Niesen F, Turnbull A, Oliver A, Parker S, et al. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J. 2008;27:704-14 pubmed publisher
    ..Based on the presented structural and functional data, a model for specific activation segment phosphorylation at non-consensus substrate sites is proposed that is likely to be common to other kinases from diverse subfamilies. ..

More Information


  1. Guilluy C, Rolli Derkinderen M, Loufrani L, Bourgé A, Henrion D, Sabourin L, et al. Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation. Circ Res. 2008;102:1265-74 pubmed publisher
    ..We identify the Ser/Thr kinase Ste20-related kinase SLK as a new kinase phosphorylating RhoA on Ser188...
  2. Fokin A, Klementeva T, Nadezhdina E, Burakov A. SLK/LOSK kinase regulates cell motility independently of microtubule organization and Golgi polarization. Cytoskeleton (Hoboken). 2016;73:83-92 pubmed publisher
    ..Such extensive rearrangement is closely related to cell polarization as a whole. The serine/threonine kinase SLK/LOSK is a potential regulator of cell motility, as it phosphorylates a series of cytoskeleton-bound proteins that ..
  3. Hao W, Takano T, Guillemette J, Papillon J, Ren G, Cybulsky A. Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38. J Biol Chem. 2006;281:3075-84 pubmed
    Expression and activity of the germinal center kinase, Ste20-like kinase (SLK), are increased during kidney development and recovery from ischemic acute renal failure...
  4. Baron K, Al Zahrani K, Conway J, LabrÃ¨che C, Storbeck C, Visvader J, et al. Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4. Biochim Biophys Acta. 2015;1853:1683-92 pubmed publisher
    The Ste20-like kinase SLK plays a pivotal role in cell migration and focal adhesion turnover and is regulated by the LIM domain-binding proteins Ldb1 and Ldb2...