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Anti-tissue Transglutaminase Antibody

Does this test have other names?


What is this test?

This test is used to see if you have celiac disease. It is also used to see how well people with the condition are doing. It is one of several blood tests that may be used to help diagnose celiac disease.


Why do I need this test?

If you have celiac disease, you are allergic to gluten. Gluten is the protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder. This means your body attacks itself. With celiac disease, your body attacks the lining of the small bowel, making it less able to absorb nutrients. The sensitivity to gluten can also cause pain in the abdomen, low blood count (anemia), tiredness, muscle and joint pain, gas, diarrhea, vomiting, weight loss, and malnutrition. 

What other tests might I have along with this test?

If your healthcare provider thinks you have celiac disease, he or she may order several other blood tests. These may look for generalized inflammation (C reactive protein or erythrocyte sedimentation rate) or poor absorption of nutrients (iron deficiency, low cell counts, or unabsorbed fat in stool). 

Your provider may also take a tissue sample (biopsy) from your small bowel to confirm the blood tests' findings. The biopsy is important to confirm a diagnosis of celiac disease. It should be done when possible. The biopsy is done using a tubelike device (endoscope) put down your throat and into the small intestine. Your provider uses it to get the sample without doing surgery. 

What do my test results mean?


Keep in mind that no one test can say for sure that you have celiac disease. Your healthcare provider will use other things to help confirm the diagnosis.


How is this test done?


Does this test pose any risks?


What might affect my test results?



How do I get ready for this test?

If the test is to diagnose celiac disease, it is best to have it before you stop eating gluten. This is because the lack of gluten could give a negative test result even if you have celiac disease. If the test is to see how well you are doing with celiac disease, you don't need to get ready for the test. Be sure your healthcare provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use.  

Online Medical Reviewer: Greco, Frank MD
Online Medical Reviewer: Sather, Rita, RN
Date Last Reviewed: 9/10/2017