TY - JOUR T1 - Towards a bottom-up understanding of antimicrobial use and resistance on the farm: A knowledge, attitudes, and practices survey across livestock systems in five African countries JF - bioRxiv DO - 10.1101/703298 SP - 703298 AU - Caudell, Mark A AU - Dorado-Garcia, Alejandro AU - Eckford, Suzanne AU - Byarugaba, Denis AU - Afakye, Kofi AU - Chansa-Kabali, Tamara AU - Kabali, Emmanuel AU - Kiambi, Stella AU - Kimani, Tabitha AU - Mainda, Geoffrey AU - Mangesho, Peter AU - Chimpangu, Francis AU - Dube, Kululeko AU - Kikimoto, Bashiru Boi AU - Koka, Eric AU - Mugara, Tendai AU - Swiswa, Samuel Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/07/15/703298.abstract N2 - The nutritional and economic potentials of livestock systems are compromised by the emergence and spread of antimicrobial resistance. A major driver of resistance is the misuse and abuse of antimicrobial drugs. The likelihood of misuse may be elevated in low- and middle-income countries where limited professional veterinary services and laissez faire access to drugs are assumed to promote non-prudent practices (e.g., self-administration of drugs). The extent of these practices, as well as the knowledge and attitudes motivating them, are largely unknown within most agricultural communities in low- and middle-income countries. The main objective of this study was to document dimensions of knowledge, attitudes and practices related to antimicrobial use and antimicrobial resistance in livestock systems and identify the livelihood factors associated with these dimensions. A mixed-methods ethnographic approach was used to survey households keeping layers in Ghana (N=110) and Kenya (N=76), pastoralists keeping cattle, sheep, and goats in Tanzania (N=195), and broiler farmers in Zambia (N=198), and Zimbabwe (N=298). Across countries, we find that it is individuals who live or work at the farm who draw upon their knowledge and experiences to make decisions regarding antimicrobial use and related practices. Input from animal health professionals is rare and antimicrobials are sourced at local, privately owned agrovet drug shops. We also find that knowledge, attitudes, and particularly practices significantly varied across countries, with poultry farmers holding more knowledge, desirable attitudes, and prudent practices compared to pastoralists households. Multivariate models showed that variation is related to several factors, including education, disease dynamics on the farm, and sources of animal health information. Study results emphasize that interventions to limit antimicrobial resistance must be founded upon a bottom-up understanding of antimicrobial use at the farm-level given limited input from animal health professionals and under-resourced regulatory capacities within most low- and middle-income countries. Establishing this bottom-up understanding across cultures and production systems will inform the development and implementation of the behavioral change interventions to combat AMR globally. ER -