Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title The metabolism of naled inhaled by rats /
Author Berteau, Peter E.
Other Authors
Author Title of a Work
Chiles, Robert E.
Year Published 1977
Report Number EPA-600/1-77-033
Stock Number PB-271 976
OCLC Number 52255442
Subjects Pesticides--Absorption and adsorption. ; Herbicides--Absorption and adsorption. ; Insecticides--Absorption and adsorption. ; Pesticides--Health aspects. ; Naled.
Additional Subjects Toxicity ; Pesticides ; Insecticides ; Particle size ; Aerosols ; Respiration ; Metabolism ; Rats ; Bioassay ; Lethal dosage ; Tables(Data) ; Deposition ; Lung ; Physiology ; Phosphorus organic compounds ; Ingestion(Biology) ; Injections(Medicine) ; Peritoneum ; Toxicology ; Laboratory animals ; Labeled substances ; Naled ; Phosphoric acid((dibromo-dichloro)ethyl-ester)-(dimethyl-ester) ; DDVP ; Metabolites
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJAD  EPA 600/1-77-033 Region 3 Library/Philadelphia, PA 05/30/2003
EJBD ARCHIVE EPA 600-1-77-033 Headquarters Library/Washington,DC 06/04/2012
EJBD  EPA 600-1-77-033 c.1 Headquarters Library/Washington,DC 05/27/2014
EJED  EPA 600/1-77/033 OCSPP Chemical Library/Washington,DC 07/01/2005
EKBD  EPA-600/1-77-033 Research Triangle Park Library/RTP, NC 06/06/2003
EKDD  EPA 600/1-77-033 NERL/ERD Library/Athens,GA 11/03/2014
NTIS  PB-271 976 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 01/01/1988
Collation x, 100 p. : ill. ; 28 cm.
Naled (Dibrom) was prepared with a (14)carbon label in the 1-ethyl position. The labeled compound was administered in appropriate formulation vehicles to female rats by the inhalation, oral or intraperitoneal routes. Treated animals were either placed in metabolism cages and their excreta and expiration of radioactivity monitored during 48 hours, or they were quickly dissected after sacrifice, the lungs and stomach extracted with ether and metabolic breakdown products analyzed for (14)C products by thin layer chromatography. Some animals were also used to determine the deposition and early distribution of inhaled naled. Urinary levels of radioactivity were higher when animals inhaled the compound than when it was administered by the other routes. Levels deposited in the lung were very low and this fact limited the generation of analytical data on the metabolic changes. However, no evidence was provided to indicate that there was a preferential metabolism to the debrominated form of naled (dichlorvos) when the compound was inhaled contrasted to other routes of administration.
"EPA-600/1-77-033." Interagency Agreement No. IAG-D5-0697. Cover title. "June 1977." Includes bibliographical references.