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Related to autacoid: autacoid substance





adrenocortical hormone
adrenocorticotropic hormone (ACTH) corticotropin.
androgenic hormone androgen.
antidiuretic hormone (ADH) vasopressin.
corpus luteum hormone progesterone.
cortical hormone corticosteroid.

estrogenic hormone estrogen.
gonadotropic hormone gonadotropin.
growth hormone release–inhibiting hormone somatostatin.
interstitial cell–stimulating hormone luteinizing hormone.
lactation hormone (lactogenic hormone) prolactin.
progestational hormone
2. progestational agent.
sex h's see sex hormones.
somatotrophic hormone (somatotropic hormone) growth hormone.
somatotropin release–inhibiting hormone somatostatin.
thyroid h's see thyroid hormones.
thyroid-stimulating hormone (TSH) thyrotropin.


A chemical substance produced by one type of cell that affects the function of different types of cells in the same region, thus functioning as a local hormone or messenger.
[G. autos, self, + eidos, form]




An organic substance, such as a hormone, produced in one part of an organism and transported by the blood, lymph, or sap to another part of the organism where it exerts a physiologic effect on that part.

au′ta·coi′dal (-koid′l) adj.


Any hormone-like substance—e.g., histamine, serotonin, angiotensin, eicosanoids, neurotensin, NO, endothelins—which is produced, acts and is metabolised locally. Vasodilating autacoids are released in response to exercise.
Vasoconstriction, vasodilation.


Endocrinology A locally acting hormone-like substance–eg, histamine, serotonin, angiotensin, eicosanoids


A hormone or other substance produced in an organ and released into the blood to be carried to other parts of the organism to produce various effects.
References in periodicals archive ?
Canatan, "Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME," Autonomic and Autacoid Pharmacology, vol.
Tomioka et al., "Serum anticholinergic activity: a biomarker for rapid progression of Alzheimer's disease," Journal of Autacoids, vol.
In response to ischemia and reperfusion, neutrophils migrate into the vessel wall and microvasculature and secrete a variety of autacoids, which lead to vasoconstriction and platelet aggregation, such as thromboxane-B2 and leukotrienes-B4 [19].
The autacoids serotonin (1 mg/mL), histamine (1 mg/mL), and prostaglandin [E.sub.2] (1 [micro]g/ mL) were employed as phlogistic agents.
Again, flavonoids present in the plant extract (13) are reported to inhibit release of autacoids and prostaglandins, thereby inhibit motility and secretion induced by castor oil (35).
Although the precise biochemical function of [Na.sup.+]-ATPase and its exact physiological role in mammalian intestinal cells remains unraveled, it has been proposed an important role of this enzyme on extracellular volume control by the fine tuning of renal sodium excretion, being a target for autacoids and hormonal selective regulation in proximal tubule cells (20-25).
Table I lists the pharmacological agents in the categories of neurological preparations, local anaesthetics, analgesics, musculoskeletal agents, autacoids and corticoids, and cardiovascular agents.
However, some important topics such as anticancer drugs, analgesics (autacoids), immunosuppressants (miscellaneous) were not at all covered in many consecutive years (2011-2015).
Effects of cyclic AMP-elevating hormones and autacoids on LPS-activated rat peritoneal, bronchoalveolar and hepatic (Kupffer) macrophages.
Cyclooxygenase is a resourceful mode of formation of specific autacoids that regulate the extent and pace of the inflammatory response.
Their therapeutic activity appears to depend on large extent upon the inhibition of defined biochemical pathway responsible for the biosynthesis of prostaglandins and other related autacoids. NSAIDs have different spectrum of activity than do the analgesics.