TY - JOUR T1 - Chemoprevention Strategies for Lung and Upper Aerodigestive Tract Cancer JF - Cancer Research JO - Cancer Res SP - 2758s LP - 2763s VL - 52 IS - 9 Supplement AU - Benner, Steven E. AU - Lippman, Scott M. AU - Hong, Waun Ki Y1 - 1992/05/01 UR - http://cancerres.aacrjournals.org/content/52/9_Supplement/2758s.abstract N2 - The field cancerization hypothesis suggests that carcinogen exposure affects the entire epithelial lining of the lungs and upper aerodigestive tract. The concept that common exposures place the entire epithelium at risk for the development of invasive cancer is supported both by the occurrence of premalignant lesions such as leukoplakia and squamous metaplasia, and by the development of multiple primary tumors within the field. Chemoprevention trials in lung and upper aerodigestive tract cancer have included studies to reverse premalignant lesions and to prevent second primary tumors. Promising results have been reported in both settings using the retinoid 13-cis-retinoid acid. Several clinical trials are in progress which attempt both to reduce cancer incidence and to determine the mechanisms and biological markers of successful chemoprevention. ©1992 American Association for Cancer Research. ER -