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I was wondering if it was possible to have managers set out of office in outlook, for those they manage. Almost every day I have to login into EMC and give myself full permission to someones mailbox and remove it when done. It's a really big pain, and I'm hoping that there is an easier way to do this, and a way that can have there managers do it.

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A very similar question was asked back in 2009 -- Do any of those options work for you (particularly the powershell one)? Also note that IMHO the better solution is to educate your users so they set their own out of office messages: Server admins and managers aren't supposed to be nannies, and if you do it for them now they'll refuse to learn how later... –  voretaq7 Jun 6 '12 at 17:05

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Why grant yourself full mailbox access, when you have the ability to utilize Powershell and Exchange specific Cmdlet's (assuming you are running an Exchange 2010 organization)?

The Set-MailboxAutoReplyConfiguration is the way forward, I would say:

To answer your question regarding the possibility to delegate the steps towards a specific group: if you utilize RBAC and assign the necessary people the necessary rights, you can delegate any Exchange related step with great ease. But inline with the response already given, I would also invest in education of the (end)users.

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