Lamictal Effectiveness I am taking Lamictal in combination with Lithium. Lamictal works moderately well for my ever-present depression. The Lithium was decreased by half 3 weeks ago due to toxicity. So far, only 1 manic episode and the depression has worsened. However, I am sure that the Lamictal is still working effectively since the depression is not as bad as in past mood swings.