Generic Name: palonosetron (injection) (PAL oh NOE se tron)
Brand Names: Aloxi

What is Aloxi?

Aloxi (palonosetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.


Aloxi is used in children only to prevent nausea and vomiting caused by cancer medicine.

Aloxi is not for preventing nausea or vomiting that is caused by factors other than chemotherapy or surgery.

Important information

You should not use Aloxi if you are allergic to palonosetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or ondansetron (Zofran).

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Tell your doctor if you forget to take your dose within 1 hour before chemotherapy. Do not take extra medicine to make up the missed dose.

Before receiving this medicine?

You should not use Aloxi if you are allergic to palonosetron.

To make sure Aloxi is safe for you, tell your doctor if you have ever had an allergic reaction to a similar medicine for nausea or vomiting, such as dolasetron (Anzemet) or ondansetron (Zofran).

FDA pregnancy category B. Aloxi is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether palonosetron passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is Aloxi given?

Take Aloxi exactly as it was prescribed for you. Aloxi is injected into a vein through an IV. A healthcare provider will give you this injection.

Aloxi is usually given 30 minutes before chemotherapy, or right before you are given anesthesia for surgery.

What happens if I miss a dose?

Because you will receive Aloxi in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?


What should I avoid while receiving Aloxi?


Aloxi side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Aloxi: hives; chest pain, difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:


Common Aloxi side effects may include:

  • constipation; or

  • headache.

  • tired feeling.


See also: Side effects (in more detail)

What other drugs will affect Aloxi?


Where can I get more information?

  • Your doctor or pharmacist can provide more information about Aloxi.

Copyright 1996-2014 Cerner Multum, Inc. Version: 4.02. Revision Date: 2014-10-28, 1:54:14 PM.