5-HTP Helps Inability to Sleep I have suffered from depression, anxiety and panic for several years, and have tried various antidepressants (the current being Wellbutrin), and Klonopin has helped amazingly with the panic disorder. But I was nervous about relying on Klonopin for bedtime low-grade anxiety (just not being able to "turn off" my brain, which I think is exacerbated by the Wellbutrin). My doc is reluctant to give me too much of the stuff, and I'd rather save it for when I really need it. But sometimes my inability to sleep drives me crazy! I started taking 50-100mg of 5-htp at bedtime when I was weaning off of SSRIs, and noticed that my bedtime restlessness improved, and I slept very soundly. Now my husband has to respond to the child with the nightmare -- I'm fast asleep! I do notice it can be a little hard to get up in the morning sometimes, not being drowsy so much as just not wanting to wake up, because sleep is so sweet. But once I'm up I do fine, better than when I take a Klonopin at bedtime. I think it's also helped with my daytime anxiety, which hasn't really been a problem lately. I usually only take 50mg, because 100mg really knocks me out, except if I'm feeling hyper, and know I need a bit more help to fall asleep. I do recommend it to anyone who's trying to rely less on medication for sleeping. I haven't noticed any side effects at all.