SSM Cardinal Glennon Children's Medical Center
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About Roseola

Roseola (also known as sixth disease, exanthem subitum, and roseola infantum) is a viral illness in young kids, most commonly affecting those between 6 months and 2 years old. It is usually marked by several days of high fever, followed by a distinctive rash just as the fever breaks.

Two common and closely related viruses can cause roseola: human herpesvirus (HHV) type 6 and possibly type 7. These viruses belong to the same family as the better-known herpes simplex viruses (HSV), but HHV-6 and HHV-7 do not cause the cold sores and genital herpes infections that HSV can cause.

Signs and Symptoms

A child with roseola typically develops a mild upper respiratory illness, followed by a high fever (often over 103°F or 39.5°C) for up to a week. During this time, the child may appear fussy or irritable and may have a decreased appetite and swollen lymph nodes (glands) in the neck.


The high fever often ends abruptly, and at about the same time a pinkish-red flat or raised rash appears on the trunk and spreads over the body. The rash's spots blanch (turn white) when you touch them, and individual spots may have a lighter "halo" around them. The rash usually spreads to the neck, face, arms, and legs.

The fast-rising fever that comes with roseola triggers febrile seizures (convulsions caused by high fevers) in about 10% to 15% of young children. Signs of a febrile seizure include:

  • unconsciousness
  • loss of control of the bladder or bowels


Roseola is contagious and spreads through tiny drops of fluid from the nose and throat of infected people. These drops are expelled when an infected person talks, laughs, sneezes, or coughs. Other people who breathe the drops in or touch them and then touch their own noses or mouths can then also become infected.



There is no known way to prevent the spread of roseola. Because the infection usually affects young kids but rarely adults, it is thought that a bout of roseola in childhood may provide some lasting immunity to the illness. Repeat cases of roseola may occur, but they are not common.



Professional Treatment

To make a diagnosis, your doctor first will take a history and do a thorough physical examination. A diagnosis of roseola is often uncertain until the fever drops and the rash appears, so the doctor may order tests to make sure that the fever is not caused by another type of infection.

Roseola usually does not require professional treatment, and when it does, most treatment is aimed at reducing the high fever. Antibiotics cannot treat roseola because a virus, not a bacterium, causes it.

Home Treatment

Acetaminophen (such as Tylenol) or ibuprofen (such as Advil or Motrin) can help to reduce your child's fever. Don't give aspirin to a child who has a viral illness because its use in such cases has been associated with Reye syndrome, which can lead to liver failure and death.

While some parents use lukewarm sponge baths to lower fever, there is no evidence to support that this really works. In fact, sponge baths can make children uncomfortable. Never give your child ice, cold water, alcohol rubs, fans, or cold baths.

To prevent dehydration from the fever, encourage your child to drink clear fluids such as water with ice chips, children's electrolyte solutions, flat sodas like ginger ale or lemon-lime (stir room-temperature soda until the fizz disappears), or clear broth. If you're still breastfeeding, breast milk can help prevent dehydration as well.

When to Call the Doctor

Call the doctor if your child is lethargic or not drinking or if you cannot keep the fever down. If your child has a seizure, seek emergency care immediately.

Reviewed by: Joel Klein, MD
Date reviewed: July 2012