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Comment: Re:More Privatizing of Science (Score 3, Interesting) 85

by kwyjibo87 (#46956013) Attached to: Scientists Create Bacteria With Expanded DNA Code




Comment: More Privatizing of Science (Score 2) 85

by kwyjibo87 (#46955895) Attached to: Scientists Create Bacteria With Expanded DNA Code





Step 4: Get bought out

Step 5: ? Profit was Step 4.


Comment: Re:A thought experiment (Score 2) 214

by kwyjibo87 (#43999481) Attached to: Supreme Court: No Patents For Natural DNA Sequences


Have we sequenced every variant of every species?






Submitted by kwyjibo87

Comment: Re:epigenetics? (Score 1) 149

by kwyjibo87 (#43029165) Attached to: Software Lets Scientists Assemble DNA



Comment: Re:Wait a second... (Score 1) 49

by kwyjibo87 (#42941289) Attached to: New Imaging Sheds Light On Basic Building Blocks of Life

Comment: In other news (Score 1) 148

by kwyjibo87 (#42875307) Attached to: Drug Testing In Mice May Be a Waste of Time, Researchers Warn

Comment: Re:More Info Please... (Score 5, Insightful) 123

by kwyjibo87 (#42828607) Attached to: Ancestor of All Placental Mammals Revealed




Comment: Re:Caffeine is a drug.. (Score 2) 212

by kwyjibo87 (#42793095) Attached to: Why It's So Hard To Predict How Caffeine Will Affect Your Body

More specifically, the chemical is a modified version of adenosine called cyclic AMP (cAMP). cAMP is generated by enzymes from ATP, the energy molecule of cells. It acts as a signal amplifier in cellular signaling cascades, and for the purposes of how caffeine affects the body, increased cAMP concentrations = more cellular metabolism. Think the adrenaline response at the cellular level.

Caffeine inhibits enzymes which break down cAMP and turn off the signal. No off switch = artificial build-up of cAMP in the cell = artificial high metabolism state.

Cocaine acts in a somewhat analogous manner, in that it doesn't increase the amount of neurotransmitters being released directly or directly stimulate neurons, but prevents released dopamine from being broken down and thus prolongs the signals artificially, leading to the psychological effects of cocaine use.

Comment: Re:Balancing potential deaths with real-today ones (Score 5, Informative) 130

by kwyjibo87 (#42246767) Attached to: Altered Immune Cells Help Girl Beat Leukemia

"[using] a disabled form of the virus that causes AIDS"

While true, this is a poor way to describe a lentiviral vector, meant to invoke the idea of using HIV to kill cancer in the minds of readers not familiar with modern molecular biology. HIV is a type of virus called a lentivirus, which itself is a type of retrovirus, which means that it takes the RNA genetic code it has packaged in the virion, chemically transforms it into DNA, and integrates this DNA into the DNA of the infected cell. Lentiviral vectors are designed such that they do this part of the viral life cycle, but are engineered to lack the genes necessary to make more viruses, so the integrated virus is dead on arrival.

In this case, the researchers kept the normal HIV surface receptors so the virus would efficiently target and "infect" T-cells from the patient; normally, lentiviruses are given a generic non-HIV receptor so they can infect any cell type you might be using in your lab experiments. The lentivirus genome contained not the normal viral genes, but a chimeric T-cell receptor designed to stimulate an immune response against CD-19, a surface protein specific to B-cells. Once this chimeric gene is integrated, the T-cells will express it on their cell surface, and stimulate the immune system to target and destroy cells that have CD-19 on them; this kills all the B-cells in the body, both healthy and cancerous. This last point is a problem brought up by TFA, that the patient now essentially has a limited auto-immune disorder as the altered T-cells persist in her body and continue to point them immune system to targeting B-cells, leaving her partially immuno-compromised (which is the funny part about using the "virus that causes AIDS" to do this).
