Table 4

Enriched biological process GOa terms in protein families born at the LCAb of the three major metazoan groups and the LCA of metazoans
Groups GO terms Description P-value
Families born at the LCA of metazoans
GO:0006355 regulation of transcription, DNA-dependent 1.29E-106
GO:0006836 neurotransmitter transport 7.59E-11
GO:0007275 multicellular organismal development 1.25E-09
GO:0006637 acyl-CoA metabolic process 4.33E-08
GO:0007186 G-protein coupled receptor protein signaling pathway 1.35E-07
GO:0007040 lysosome organization and biogenesis 4.78E-06
GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway 4.78E-06
GO:0030704 vitelline membrane formation 6.47E-06
GO:0006508 proteolysis 1.48E-05
GO:0006094 gluconeogenesis 1.90E-05
GO:0006665 sphingolipid metabolic process 3.24E-05
GO:0007179 transforming growth factor beta receptor signaling pathway 3.24E-05
GO:0006869 lipid transport 5.22E-05
GO:0045449 regulation of transcription 9.33E-05
GO:0006835 dicarboxylic acid transport 3.50E-04
GO:0007600 sensory perception 3.50E-04
GO:0045087 innate immune response 8.15E-04
GO:0007026 negative regulation of microtubule depolymerization 9.14E-04
Families born at the LCA of nematodes
GO:0051085 chaperone cofactor-dependent protein folding 9.14E-04
GO:0007186 G-protein coupled receptor protein signaling pathway 3.54E-116
GO:0016998 cell wall catabolic process 7.49E-06
GO:0005992 trehalose biosynthetic process 2.37E-05
GO:0006812 cation transport 2.98E-04
Families born at the LCA of arthropods
GO:0006030 chitin metabolic process 1.08E-22
GO:0006814 sodium ion transport 2.32E-18
GO:0006950 response to stress 2.02E-11
GO:0007608 sensory perception of smell 4.74E-11
Families born at the LCA of vertebrates
GO:0007186 G-protein coupled receptor protein signaling pathway 7.41E-155
GO:0006955 immune response 1.29E-39
GO:0001558 regulation of cell growth 2.57E-10
GO:0007154 cell communication 4.19E-10
GO:0050909 sensory perception of taste 4.88E-10
GO:0045087 innate immune response 1.04E-09
GO:0015671 oxygen transport 7.68E-09
GO:0048468 cell development 1.03E-08
GO:0006691 leukotriene metabolic process 7.08E-08
GO:0042981 regulation of apoptosis 1.99E-07
GO:0019882 antigen processing and presentation 3.04E-07
GO:0009395 phospholipid catabolic process 3.60E-06
GO:0006915 apoptosis 5.43E-06
GO:0016049 cell growth 2.51E-05
GO:0006486 protein amino acid glycosylation 3.09E-05
GO:0006952 defense response 5.80E-05
GO:0006071 glycerol metabolic process 8.96E-05
GO:0009607 response to biotic stimulus 2.40E-04
GO:0030178 negative regulation of Wnt receptor signaling pathway 2.54E-04
GO:0043065 positive regulation of apoptosis 2.54E-04

a GO, Gene Onthology; b LCA, Last Common Ancestor.

Wang et al.

Wang et al. BMC Evolutionary Biology 2012 12:138   doi:10.1186/1471-2148-12-138

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