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Orthodenticle homeobox 1
Symbols OTX1 ; FLJ38361; MGC15736
External IDs OMIM600036 MGI97450 HomoloGene7875 GeneCards: OTX1 Gene
Species Human Mouse
Entrez 5013 18423
Ensembl ENSG00000115507 ENSMUSG00000005917
UniProt P32242 P80205
RefSeq (mRNA) NM_001199770 NM_011023
RefSeq (protein) NP_001186699 NP_035153
Location (UCSC) Chr 2:
63.28 – 63.28 Mb
Chr 11:
21.99 – 22 Mb
PubMed search [1] [2]

Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.[1][2]

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. The Otx gene is active in the region of the first gill arch, which is related to the upper and lower jaw and two of the bones of the ear.[3] A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.[2]


  1. ^ Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (Dec 1994). "Chromosome locations of human EMX and OTX genes". Genomics 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790. 
  2. ^ a b "Entrez Gene: OTX1 orthodenticle homeobox 1". 
  3. ^ Shubin, Neil "Your Inner Fish" 2009

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