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Ulf Schwarz Initial Version release date 28/02/2017 Institute for Formal Ontology and Medical Information Science (IFOMIS) Viral Desease Ontology Trunk participates in at some time has participant at some time concretizes function of at all times quality of at all times role of at all times has quality at some time disposition of at all times has continuant part at all times has disposition at some time occupies temporal region has temporal occupant span-of has role at all times has proper continuant part at some time proper part of continuant at some time part of continuant at some time has continuant part at some time has proper temporal part history of has continuant part at all times that part exists has role has quality at all times quality of at some time The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with mosaicism in which the different cell populations are derived from a single individual. NCIT Chimärismus chimerism UMLS_CUI C0333678 White blood cell Leukozyt leukocyte Granular leucocyte Granulocyte granular leukocyte granulärer Leukozyt Agranular leukocyte Mononuclear leukocyte agranulärer Leukozyt nongranular leukocyte Stammzelle stem cell Probe A planned process that captures an image of an object. OBI Bilderzeugung image creation A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. Organismus organism Krankenhaus Alter cardinality extra or missing physical or functional parts has or lacks parts of type mereological quality number number of Anzahl somatic stem cell somatische Stammzelle Bone marrow-derived hemopoietic stem cell blutbildende Stammzelle aus Knochenmark multipotente Stammzelle multipotent stem cell Knochenmarkstammzelle bone marrow stem cell blood-forming stem cell blutbildende Stammzelle hemopoietic stem cell Blutstammzelle Peripheral blood stem cell Institutionsidentifikationsnummer Zelle 1 Bestrahlung A patient is any recipient of health care services. The patient is most often ill or injured and in need of treatment by a physician, advanced practice registered nurse, physiotherapist, physician assistant, psychologist, dentist, podiatrist, veterinarian, or other health care provider. Als Patient bzw. Patientin (aus lateinisch patiens, deutsch ‚geduldig‘, ‚aushaltend‘, ‚ertragend‘, adjektivisches 1. Partizip von pati, deutsch ‚erdulden‘, ‚leiden‘ wird ein Mensch bezeichnet, der ärztliche Dienstleistungen oder Dienstleistungen anderer Personen, die eine Heilbehandlung durchführen, in Anspruch nimmt. Dabei kann es sich um die Vorbeugung, Feststellung oder medizinische Behandlung von Krankheiten oder Folgen eines Unfalls handeln. Inflammation of the bladder resulting in bloody urine NCIT UMLS_CUI C0085692 hämorrhagische Zystitis (HC) hemorrhagic cystitis An infection caused by the BK virus. It usually causes an asymptomatic infection, except in immunocompromised individuals where it may cause nephropathy or hemorrhagic cystitis. NCIT UMLS_CUI C1096691 bk virus infection A clinical treatment in which hematopoietic stem cells are transferred from a HLA half-matched donor to a recipient. NCIT HLA-Haploidentical Hematopoietic Cell Transplantation haploidentical hematopoietic cell transplantation A genus of the family herpesviridae, subfamily betaherpesvirinae, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. NCIT CMV CYTOMEGALOVIRUS Cytomegalovirus (CMV) HHV-5 HUMAN HERPESVIRUS 5 cytomegalovirus FDA_UNII_Code 7COI029E6K NCBI_Taxon_ID 10358 UMLS_CUI C0010825 A virus that has DNA as its genetic material and does not use an RNA intermediate during replication. NCIT DNA Virus dna virus UMLS_CUI C0012923 A species of Herpetoviridae that is responsible for infectious mononucleosis (glandular fever). Discovered in 1964, this virus has been associated with Burkitt's lymphoma in South African children and with nasopharyngeal carcinoma in Asian populations. NCIT EBV Epstein Barr Virus FDA_UNII_Code 2A26YW7PNX HHV-4 HUMAN HERPESVIRUS 4 Lymphocryptovirus Virus-Epstein-Barr epstein-barr virus NCBI_Taxon_ID 10376 UMLS_CUI C0014644 A heterogeneous family of morphologically similar viruses, all of which contain double-stranded DNA and which infect man and a wide variety of other vertebrates. Infections produce type A inclusion bodies; in many instances, infection may remain latent for many years, even in the presence of specific circulating antibodies. Virions are enveloped, ether-sensitive, and vary up to 200 nm in diameter; the nucleocapsids are 100 nm in diameter and of icosahedral symmetry, with 162 capsomeres. The family includes herpes simplex virus, cytomegalovirus, EB virus (all of which infect humans) and many others. NCIT Herpes Virus Herpesviridae UMLS_CUI C0019369 Virus-Herpes Herpesvirus herpesvirus NCBI_Taxon_ID 10292 A non-taxonomic group of animal viruses associated with or causing papillomas or polyomas. NCIT UMLS_CUI C0319132 papovavirus A genus of double-stranded DNA viruses. The viral particles are not enveloped and are icosahedral in structure. NCIT polyomavirus NCBI_Taxon_ID 10624 UMLS_CUI C0032556 A virus that has double stranded DNA as its genetic material. NCIT UMLS_CUI C1512048 dsDNA Virus Doppelsträngiger DNA Virus double stranded dna virus A therapeutic procedure that involves the transplantation of hematopoietic stem cells, either with the patient as their own donor or from a donor to a patient. This can be used for treatment of malignant and non-malignant diseases. NCIT HCT stem cell transplantation hematopoietic cell transplantation Stem cell transfer or transplantation in which the patient is his own donor. NCIT autologous stem cell transplantation autologous hematopoietic stem cell transplantation A small volume of blood removed for testing or storage. NCIT Blutprobe blood sample The selection and obtaining of small representative quantities of biological material for the purpose of analysis; also, in biomedical statistics, sampling is the selection and implementation of statistical observations in order to estimate properties of an underlying population; also, in environmental science, the collection of representative specimens analyzed to characterize site conditions. NCIT Probennahme sampling A disorder resulting from the presence and activity of a microbial, viral, fungal, or parasitic agent. It can be transmitted by direct or indirect contact. NCIT Infectious Disease UMLS_CUI C0009450 infectious disorder UMLS_CUI C1336809 transplant-related disorder A group of non-neoplastic and neoplastic disorders resulting from the deregulation and/or deficiency of immune system functions. It includes autoimmune disorders (e.g., lupus erythematosus, dermatomyositis, rheumatoid arthritis), congenital and acquired immunodeficiency syndromes including the acquired immune deficiency syndrome (AIDS), and neoplasms (e.g., lymphomas and malignancies secondary to transplantation). NCIT Immunodeficiency and Immunosuppression Disorders UMLS_CUI C1334156 immune system and related disorders The determination of the number of red blood cells, white blood cells, and platelets in a blood sample. NCIT CBC FBC Full Blood Count Complete Blood Count UMLS_CUI C0005771 blood cell count A reaction, which may be fatal, in an immunocompromised subject (host) who has received an antigenically incompatible tissue transplant (graft) from an immunocompetent donor. The reaction is secondary to the activation of the transplanted cells against those host tissues that express an antigen not expressed by the donor, and is seen most commonly following bone marrow transplantation; acute disease is seen after 5-40 days, and chronic disease occurs weeks to months after transplantation. NCIT GVHD Graft vs Host Disease Graft-Versus-Host-Disease Runt Disease UMLS_CUI C0018133 graft-versus-host disease graft versus host disease UMLS_CUI C0042769 viral infection A non-neoplastic or neoplastic disorder that develops in a patient with immunodeficiency. Representative examples include AIDS-related disorders and disorders that develop following organ transplantation. NCIT Immunodepression-Related Disorder Immunosuppression disorders Immunosuppression-Related Disorder UMLS_CUI C1334159 immunodeficiency-related disorder A facility equipped and competent to conduct scientific experiments, observations, tests, investigations, and/or to manufacture chemicals or medical products. NCIT Labor laboratory EBV Infection UMLS_CUI C0149678 epstein-barr virus infection A clinical treatment in which hematopoietic stem cells (HSCs) are transferred from one genetically dissimilar individual to another. NCIT allogeneic hematopoietic stem cell transplantation Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft. PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type. (WHO, 2001) NCIT ICD-O-3_Code 9971/1 PTLD UMLS_CUI C0432487 post-transplant lymphoproliferative disorder A laboratory test to measure hematopoietic components and investigate hematologic disorders in a blood sample. NCIT Blood Test Hematology Procedure UMLS_CUI C0200627 hematology test A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, usually affecting the skin, liver, and GI tract. The onset is usually within one hundred days of transplantation or immunologic manipulation. NCIT UMLS_CUI C0856825 aGvHD acute graft versus host disease A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, and may affect multiple organs with manifestations similar to autoimmune diseases. The onset is usually within three years of transplantation or immunologic manipulation. NCIT Chronic GVHD Graft versus host disease, chronic UMLS_CUI C0867389 chronische GvHD chronic graft versus host disease Non-Neoplastic Disease Non-neoplastic condition, NOS Non-neoplastic disorder, NOS UMLS_CUI C1709246 non-neoplastic disorder A herpesvirus infection caused by Cytomegalovirus. Healthy individuals generally do not produce symptoms. However, the infection may be life-threatening in affected immunocompromised patients. The virus may cause retinitis, esophagitis, gastritis, and colitis. Morphologically, it is characterized by the presence of intranuclear inclusion bodies. NCIT CMV Infection HCMV Infection UMLS_CUI C0010823 cytomegaloviral infection A classification of blood based on the presence or absence of inherited antigenic substances on the surface of erythrocytes. NCIT Blutgruppe blood group A blood group system based on recognition of inherited differences in the H antigen as expressed on erythrocytes. NCIT AB0 blood group A blood group indicating the presence on erythrocytes of only the A form of the H Antigen. NCIT Blutgruppe A blood group A A blood group indicating the presence on erythrocytes of only the B form of the H Antigen. NCIT Blutgruppe B blood group B A blood group indicating the presence on erythrocytes of both the A and B forms of the H Antigen NCIT Blutgruppe AB blood group AB A blood group indicating the absence on erythrocytes of both the A and B forms of the H Antigen. NCIT Blutgruppe 0 blood group 0 A fictitious name used when the person performs a particular social role. NCIT UMLS_CUI C0033824 Pseudonym pseudonym The circumstance or condition that results in the death of a living being. NCIT COD Todesursache cause of death A double stranded DNA virus in the polyomavirus family. It is widespread but usually causes an asymptomatic infection, except in immunocompromised individuals. NCIT BK POLYOMAVIRUS BKV NCBI_Taxon_ID 10629 UMLS_CUI C0005670 Papovavirus BKV Polyomavirus BK Polyomavirus Type BK bk virus An infectious or non infectious disorder characterized by signs and symptoms derived from focal or extensive tissue infiltration by acute (e.g., polymorphonuclear) or chronic (e.g., lymphocytic-plasmacytic) inflammatory cells. Representative examples of infectious disorders include viral infections, bacterial infections, and parasitic infections. Representative examples of non-infectious inflammatory disorders include inflammatory bowel disease and inflammatory polyps. NCIT UMLS_CUI C1290884 inflammatory disorder UMLS_CUI C0042776 Virus virus a portion of urine collected from an organism OBI Urinprobe urine specimen Lymphozyt lymphocyte Monozyt monocyte Cell which has as its direct part a maximally connected part of protoplasm. Examples: hepatocyte, erythroblast, skeletal muscle cell, megakaryocyte. FMA Kernhaltige Zelle nucleated cell ttp:// Blutzelle Haemal cell hematocyte hemocyte Hämozyten hemal cell differentiated hemal cell Nucleated cell which has one or more diploid sets (46 pairs) of chromosomes. FMA Diploid cell somatic cell somatische Zelle Laboreingang laboratory receipt A directive information entity that represents a mathematical relationship which relates changes in a given response to changes in one or more factors. A statistical model is a formalization of relationships between variables in the form of mathematical equations. statistical model; Modell model OBCS: Ontology of Biological and Clinical Statistics Prädiktives Modell predictive model Institutionsname institution name Spender-Rolle donor role Organ donor is a person who allows an organ of theirs to be removed, legally, either by consent while the donor is alive or after death with the assent of the next of kin. IFOMIS Spender donor IDDonor Spender ID donor identifier Verwandtschaftsgrad degree of kinship graft loss GvHD Hautstadium stage of skin GvHD GvHD Leberstadium stage of liver GvHD GvHD Darmstadium stage of instestine GvHD graft loss nach TX in Tagen time of graft loss in days after stem cell transplantation A quality that inheres in an bearer by virtue of how that bearer interacts with radiation. PATO radiation quality A radiation quality inhering in a bearer by virtue of what the bearer receives as a result of being exposed to ionizing radiation. PATO radiation exposure saGvHD late acute graft versus host disease stage of chronic graft versus host disease aGvHD Grad stage of acute graft versus host disease date 4 nach TX GvHD Auftreten nach TX in Tagen The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value. EFO Hämatokrit hematocrit A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years. Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia. NCIT leukemia umls_cui: C0023418 A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). NCIT acute leukemia ALL Precursor Lymphoblastic Leukemia acute lymphoblastic leukemia A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification). NCIT AML Acute Granulocytic Leukemia acute myeloblastic leukemia The most common type of chronic lymphoid leukemia. It comprises 90% of chronic lymphoid leukemias in the United States. Morphologically, the neoplastic cells are small, round B-lymphocytes. This type of leukemia is not considered to be curable with available therapy. (WHO, 2001) NCIT CLL Chronic B-Cell Lymphocytic Leukemia chronic lymphocytic leukemia Der Begriff myelodysplastische Syndrome (MDS) umfasst eine Reihe von Erkrankungen des Knochenmarks, bei denen zu wenig funktionstüchtige Blutzellen gebildet werden. Die einzelnen MDS-Formen unterscheiden sich hinsichtlich ihres Verlaufs, der Behandlungsmöglichkeiten und des Risikos, in eine akute Leukämie überzugehen. Die Erkrankung gehört zu den häufigsten bösartigen Bluterkrankungen des Erwachsenen und tritt vor allem bei Patienten über 60 Jahren auf. Auch wenn MDS heute noch nicht medikamentös heilbar sind, konnten in den letzten Jahren die Diagnostik und die Behandlungsmöglichkeiten durch neue wissenschaftliche Erkenntnisse stetig weiter verbessert werden. MDS Myelodysplastische Syndrome Auftragstag Laborauftrag GvHD Prophylaxe GvHD prophylaxis GVHD-Grad undefined GVHD-Grad undefiniert Todeszeitpunkt in Tagen ab Stammzelltranplantation time of death in days after stem cell transplantation Alter bei Stammzellentransplantation age at stem cell transplantation GVHD-Grad IV GVHD-Grade 4 GVHD-Grad III GVHD-Grade 3 GVHD-Grad II GVHD-Grade 2 GVHD-Grad I GVHD-Grade 1 GVHD-Grad carbon group molecular entity A main group molecular entity that contains one or more atoms of a p-block element. CHEBI p-block compounds p-block molecular entities p-block molecular entitiy p-block molecular entity realized by realizes is concretized as has function at some time has role has proper continuant part at all times has material basis at all times has occurrent part has proper occurrent part proper temporal part of proper part of occurrent Kohlenstoffhydrat Lipide Rezidiv m männlich weiblich f w Alter bei Diagnose Todeszeitpunkt