Flavivirus Reproduction Inhibitors

  • Molecular dynamics simulations of flavivirus envelope proteins, analysis of intrinsic determinants of virion properties
  • Design of small molecule antiviral compounds against tick-borne encephalitis, dengue fever, and other diseases caused by flaviviruses


Flaviviruses are the cause of dangerous infectious diseases such as dengue fever, West Nile fever, yellow fever and tick-borne encephalitis.

Based on the virtual screening results, we have developed small molecule compounds having record activity against tick-borne encephalitis virus (IC50 0.07 uM).