Search Antibody, Protein, and ELISA Kit Solutions

Hsp90 beta Antibody (OASE00051)

  • Catalog#: OASE00051
  • Inquire
Request Bulk Order Quote

Conjugation Options

OASE00051-FITC Conjugated

OASE00051-HRP Conjugated

OASE00051-Biotin Conjugated

Gene Symbol:
NCBI Gene Id:
Official Gene Full Name:
Swissprot Id:
Protein Accession #:
Replacement Item:
This antibody may replace item sc-1055 from Santa Cruz Biotechnology.
Protein G Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express HSP90AB1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express HSP90AB1.
Recombinant human Hsp90beta; Specificity mapped to amino acids 185-335
Predicted Species Reactivity:
Human (Beta specific)
Reconstitution and Storage:
Store at -20C. Shipping in Blue Ice or 4C.
Printable datasheet for OASE00051
1ug/ml was sufficient for detection of hsp90beta by Western Blot in 20ug of HeLa lysate.
Additional Information:
Background Info: Detects 90kDa proteins corresponding to the molecular mass of Hsp90beta.
Scientific Background: HSP90 is an abundantly and ubiquitously expressed heat shock protein. It is understood to exist in two principal forms alpha and beta, which share 85% sequence amino acid homology. The two isoforms of Hsp90 are expressed in the cytosolic compartment (1). Despite the similarities, HSP90alpha exists predominantly as a homodimer while HSP90beta exists mainly as a monomer.(2) From a functional perspective, hsp90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex. (3-6) Furthermore, Hsp90 is highly conserved between species; having 60% and 78% amino acid similarity between mammalian and the corresponding yeast and Drosophila proteins, respectively.
Certificate of Analysis: 1ug/ml was sufficient for detection of Hsp90beta in 20ug of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.
Storage Buffer:
PBS pH7.2, 50% glycerol
Target Reference:
1. Nemoto, T. et al. (1997) J.Biol Chem. 272, 26179-26187.
2. Minami, Y, et al. (1991), J.Biol Chem. 266, 10099-10103.
3. Arlander SJH, et al. (2003) J Biol Chem 278, 52572-52577.
4. Pearl H, et al. (2001) Adv Protein Chem 59,157-186.
5. Neckers L, et al. (2002) Trends Mol Med 8:S55-S61.
6. Pratt W, Toft D. (2003) Exp Biol Med 228:111-133.
7. Pratt W, Toft D. (1997) Endocr Rev 18,306–360.
8. Pratt WB. (1998) Proc Soc Exptl Biol Med 217, 420–434.
9. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91, 8324–8328.
10. Kishimoto J, et al. (2005). Cell Stress and Chaperones. 10 (4), 296-311.

Product Reviews

Tips Information:

Tell us what you think about this item!

Write A Review
    Please, wait...