Nicotinamide adenine dinucleotide phosphate

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Nicotinamide adenine dinucleotide phosphate
NADP+ phys.svg
CAS number 53-59-8 YesY
PubChem 5885
ChemSpider 5674 YesY
ChEBI CHEBI:44409 YesY
Jmol-3D images Image 1
Molecular formula C21H29N7O17P3
Molar mass 744.41 g mol−1
Infobox references



In plants[edit]


In animals[edit]




Biological functions[edit]

NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of ROS (reactive oxygen species), allowing the regeneration of GSH (reduced glutathione).[3] NADPH is also used for anabolic pathways, such as lipid synthesis, cholesterol synthesis, and fatty acid chain elongation.


Ball-and-stick models of NADP+ and NADPH

See also[edit]


  1. ^ Hanukoglu, I; Rapoport, R (Feb–May 1995). "Routes and regulation of NADPH production in steroidogenic mitochondria". Endocrine research 21 (1–2): 231–41. doi:10.3109/07435809509030439. PMID 7588385. Retrieved 6 April 2012. 
  3. ^ Rush, Glenn F.; Gorski, Joel R.; Ripple, Mary G.; Sowinski, Janice; Bugelski, Peter; Hewitt, William R. "Organic hydroperoxide-induced lipid peroxidation and cell death in isolated hepatocytes". Toxicology and Applied Pharmacology 78 (3): 473–483. doi:10.1016/0041-008X(85)90255-8. 
  4. ^ Ogawa, K.; Suzuki, K.; Okutsu, M.; Yamazaki, K.; Shinkai, S. (2008). "The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly". Immun Ageing 5: 13. doi:10.1186/1742-4933-5-13. PMC 2582223. PMID 18950479.