2c5v Summary


PDB entry 2c5v (supersedes 1oku)


The structure was published by Kontopidis, G., Mcinnes, C., Pandalaneni, S.R., et al., Wang, S., Walkinshaw, M.D., and Fischer, P.M., in 2006 in a paper entitled "Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.


This PDB entry contains a complex of 3 biomacromolecules, namely CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, and ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2.




C CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%
B CYCLIN A2 P20248 (174-432) (CCNA2_HUMAN)search Homo sapienssearch < 90% 259 99%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P20248 (174 - 432) CYCLIN A2 Homo sapiens

B, D Cyclinsearch Cyclin A; domain 1search Cyclin, N-terminal domainsearch, Cyclin, C-terminal domainsearch

A, C (P24941) meiotic nuclear divisionsearch DNA replicationsearch positive regulation of transcription, DNA-templatedsearch protein phosphorylationsearch mitotic G2 phasesearch potassium ion transportsearch mitotic G1 DNA damage checkpointsearch positive regulation of DNA-dependent DNA replication initiationsearch cellular response to DNA damage stimulussearch phosphorylationsearch histone phosphorylationsearch G2/M transition of mitotic cell cyclesearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch centrosome duplicationsearch regulation of gene silencingsearch G1/S transition of mitotic cell cyclesearch Ras protein signal transductionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cell divisionsearch positive regulation of cell proliferationsearch cellular response to nitric oxidesearch mitotic cell cyclesearch mitotic nuclear divisionsearch blood coagulationsearch cell cyclesearch DNA repairsearch protein bindingsearch transferase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch nucleotide bindingsearch metal ion bindingsearch histone kinase activitysearch cyclin bindingsearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch nucleoplasmsearch transcription factor complexsearch cytosolsearch nucleussearch cytoskeletonsearch endosomesearch cytoplasmsearch Cajal bodysearch chromosome, telomeric regionsearch X chromosomesearch cyclin-dependent protein kinase holoenzyme complexsearch condensed chromosomesearch centrosomesearch microtubule organizing centersearch Y chromosomesearch

Chain InterPro annotation
B, D Cyclin, C-terminal domainsearch Cyclin, N-terminalsearch Cyclin-likesearch Cyclin A/B/D/E/Fsearch Cyclin A, chordatessearch