BEGIN:VCALENDAR PRODID:-//AT Content Types//AT Event//EN VERSION:2.0 METHOD:PUBLISH BEGIN:VEVENT DTSTAMP:20140712T230724Z CREATED:20130306T203103Z UID:ATEvent-71b6284dbde042fdbd8567d48d89bb86 LAST-MODIFIED:20130306T203103Z SUMMARY:Chemical Exchange Sensitive MRI: Amide and Amine Protons DTSTART:20130311T180000Z DTEND:20130311T190000Z DESCRIPTION:Abstract:\nImaging the pH and chemical compositions of the brain is important for understanding brain function and may provide u seful information in clinical applications of brain diseases. Chemica l exchange of protons between water and biomolecules can be exploited in magnetic resonance imaging (MRI) for measuring pH and metabolite/pr otein concentration changes which are detected indirectly through wate r signal with enhanced sensitivity by applying saturation or spin-lock ing radiofrequency pulses. Exchangeable amide and amine protons are a bundant in the brain and have been shown to be promising chemical exch ange sites in preclinical studies of brain cancer and stroke. In this talk\, I will present the physical principles and the quantification and optimization issues of chemical-exchange sensitive MRI and discuss the in vivo signal source of MRI techniques sensitive to the amide- a nd amine–water proton exchange. LOCATION:Medical Research Building D Conference Room CONTACT:Ann Sherman\, 919-966-4397\, CLASS:PUBLIC END:VEVENT END:VCALENDAR