TY - JOUR T1 - Muscle Mitochondrial Capacity and Endurance in Adults with Type 1 Diabetes JF - bioRxiv DO - 10.1101/862086 SP - 862086 AU - Hewgley, Riley A. AU - Moore, Bethany T. AU - Willingham, T. Bradley AU - Jenkins, Nathan T. AU - McCully, Kevin K. Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/12/02/862086.abstract N2 - The impact of type 1 diabetes (T1D) on muscle endurance and oxidative capacity is currently unknown.Purpose Measure muscle endurance and oxidative capacity of adults with T1D compared to controls.Methods A cross-sectional study design with a control group was used. Subjects (19-37 years old) with T1D (n=17) and controls (n=17) were assessed with hemoglobin A1c (HbA1c) and casual glucose. Muscle endurance was measured with an accelerometer at stimulation frequencies of 2, 4, and 6 Hz for a total of nine minutes. Mitochondrial capacity was measured using near-infrared spectroscopy after exercise as the rate constant of the rate of recovery of oxygen consumption.Results T1D and control groups were similar in age, sex, height, and race. The T1D group had slightly higher BMI values and adipose tissue thickness over the forearm muscles. Casual glucose was 150±70 mg/dL for T1D and 98±16 mg/dL for controls (P=0.006). HbA1c of T1D subjects was 7.1±0.9% and 5.0±0.4% for controls (P&lt;0.01). Endurance indexes at 2, 4, and 6 Hz were 94.5±5.2%, 81.8±8.4%, and 68.6±13.5% for T1D and 94.6±4.1%, 85.9±6.3%, and 68.7±15.4% for controls (p = 0.97, 0.12, 0.99, respectively). There were no differences between groups in mitochondrial capacity (T1D= 1.9±0.5 min−1 and control=1.8±0.4 min−1, P=0.29) or reperfusion rate (T1D= 8.8±2.8s and control=10.3±3.0s, P=0.88). There were no significant correlations between HbA1c and either muscle endurance, mitochondrial capacity or reperfusion rate.Conclusions Adults with T1D did not have reduced oxidative capacity, muscle endurance or muscle reperfusion rates compared to controls. HbA1c also did not correlate with muscle endurance, mitochondrial capacity or reperfusion rates. Future studies should extend these measurements to older people or people with poorly-controlled T1D. ER -