Fluvoxamine for Insomnia I find fluvoxamine somewhat sedating. It doesn't seem to get to the underling problem in quite the same way that amitriptyline did (before the side effects built up), or mirtazapine does. But in combination with mirtazapine it gives me reasonable sleep and reasonable alertness (though both could be better). I've also used it in combination with very small amounts of zopiclone, a combination which worked but which I didn't much like.