Chegg Guided Solutions for Fundamentals of Biochemistry Life at the Molecular Level 4th Edition: Chapter 12.4

0 Stars(0 users)
  • Step 1 of 3

    Structure based drug design uses techniques such as X-ray crystallography and NMR spectroscopy to depict the structure of the drug target, for example, an enzyme and its interactions with a drug candidate. Other techniques are also used to understand the type of interactions, charges on the surface and the groups involved in bonding. The structure based drug design approach involves utilization of direct visualization techniques, computation techniques, quantum mechanistic for the development of new drugs. Once all the information is obtained, suitable substitutes for the drug candidate are synthesized and screened. Thus, this kind of approach reduces the number of compounds to be synthesized for obtaining a lead compound.

  • Step 2 of 3

    Combinatorial chemistry involves the synthesis of numerous related compounds often using a single procedure, thus it is rapid and inexpensive. Further, all these compounds are evaluated using robotic high throughput screening techniques. When the structure of a drug candidate (hit) is known, its various substitutions can be synthesized and screened to obtain a lead compound. Or if a lead compound can be synthesized in a stepwise manner from smaller modules, then the substituent on each of these modules can be varied in parallel to obtain a library of related compounds.

  • Step 3 of 3

    Thus, structure based drug design approach follows drug designing using various techniques and then synthesizes few compounds as drug candidates; while combinatorial chemistry involves synthesis of a series of related compounds to obtain a compounds library, which can be screened for drug candidates.

Select Your Problem