Could the combination of Benicar and lisinopril cause a decrease in kidney function?

  • Q: Does taking Benicar and lisinopril together have the possibility of causing decreased kidney function? I've been seeing a physician's assistant who has been trying to figure out why it's been going down so much, and I just saw a different one recently for a severe migraine who says this could be the reason.
  • A: Benicar (olmesartan) belongs to the class of drugs known as angiotensin II receptor blockers. lisinopril is an angiotensin-converting enzyme inhibitor (or ACE inhibitor). These drugs work on chemicals in the kidneys that affect blood pressure. Because of the way these drugs work, changes in kidney function can occur. The use of angiotensin II receptor blockers and ACEinhibitors together should be closely monitored. There is an increased risk of diarrhea, low blood pressure, fainting, high potassium levels, and kidney problems that could lead to serious complications. When your doctor prescribes a new medication, be sure to discuss all your prescription and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals, and herbals, as well as the foods you eat. Always keep a current list of the drugs and supplements you take and review it with your health care providers and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Michelle McDermott, PharmD
This question was answered on October 08, 2010.


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