• PN: B111523


45x Ab-conjugated beads (S5P10 - human VEGF-C Ab-bead). PN: B111523A. One vial containing 100 µL of anti-human VEGF-C conjugated to AimPlex Bead S5P10.

25x Biotin-detection Ab (human VEGF-C Biotin-dAb). PN: B111523B. One vial containing 100 µL of biotinylated anti-human VEGF-C.

Lyophilized Standard Mix-Human Group 4 Panel A. PN: HG4009A. One vial containing lyophilized recombinant human BDNF, beta-NGF, EGF, FGF basic, OPG, OPN, PDGF-AB and VEGF-C.   Note: If multiple analyte kits on the above target list are ordered as a panel, only one vial of standard mix is supplied for those analyte kits.

STORAGE:  2-8 C in the dark.


APPLICATION: Optimal antibody pair and antigen standard for assaying human VEGF-C.  Can be multiplexed with other analytes in Human Group 4.  To be used in conjunction with the AimPlex NR Basic Kit (PN: P100001) and a diluent kit. Refer to the AimPlex Multiplex Immunoassay User Manual and kit inserts for the assay procedure.

Important: Sample types containing low levels of platelets such as platelet-poor plasma are recommended.

For Research Use Only.  Not for use in diagnostic procedures.

Assay Specifications:


Sensitivity (LOD): < 5 pg/mL

Quantitation range:

LLOQ: < 10 pg/mL

ULOQ: > 5,000 pg/mL

Standard dose recovery: 70-130%

Intra-assay CV: < 10%

Inter-assay CV: < 20%

Cross-reactivity of analytes in Human Group 4: Negligible

Sample volume: 15 µL/test


Vascular Endothelial Growth Factor C (VEGF-C) is a member of the platelet-derived growth factor/ vascular endothelial growth factor (PDGF/VEGF) family. The main function of VEGF-C is in lymphangiogenesis, where it acts on lymphatic endothelial cells primarily via its receptor VEGFR-3 promoting survival, growth and migration. It was discovered in 1996 as a ligand for the orphan receptor VEGFR-3.  It has been shown to be a specific growth factor for lymphatic vessels in a variety of models. VEGF-C can also promote the growth of blood vessels and regulate their permeability. The effect on blood vessels can be mediated via its primary receptor VEGFR-3 or its secondary receptor VEGFR-2. Apart from vascular targets, VEGF-C is also important for neural development and blood pressure regulation. Diseases associated with VEGFC include lymphedema, hereditary and breast carcinoma.


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2.      Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo K (Jan 1996). "A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases". The EMBO Journal 15 (2): 290–298. PMC 449944. PMID 8617204.

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