@article{Hartkoorn:199016, title = {Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis}, author = {Hartkoorn, Ruben C. and Uplekar, Swapna and Cole, Stewart T.}, publisher = {Amer Soc Microbiology}, journal = {Antimicrobial Agents And Chemotherapy}, address = {Washington}, number = {5}, volume = {58}, pages = {3. 2979-2981}, year = {2014}, abstract = {The antileprosy drug clofazimine is also of interest for the treatment of multidrug-resistant tuberculosis. To understand possible resistance mechanisms, clofazimine-resistant Mycobacterium tuberculosis mutants were isolated in vitro, and, unexpectedly, found to be cross-resistant to bedaquiline. Mutations in the transcriptional regulator Rv0678, with concomitant upregulation of the multisubstrate efflux pump, MmpL5, accounted for this cross-resistance. Mutation in Rv0678 should therefore be considered a confounding factor for the treatment of tuberculosis with clofazimine or bedaquiline.}, url = {http://infoscience.epfl.ch/record/199016}, doi = {10.1128/Aac.00037-14}, }