Protein name: FLVCR1 Aliases: FLVCR, MFSD7B, AXPC1, PCARP Substrates: heme Transport type: unknown Tissue and cellular expression: ubiquitous, high expression in intestine, liver, kidney, brain, bone marrow Subcellular expression: located on the plasma membrane Disease: posterior column ataxia, retinitis pigmentosa (PCARP) syndrome, Diamond-Blackfan anemia (DBA) Locus: 1q32.3 Sequence ID: NP_054772.1, NM_014053.3 Gene ID: 28982 Splice variants: 4 splice variants observed in DBA, lacking exon 2 or 3 ? exon 6, an additional splice variant lacking exon 6 seen in both control and DBA erythroid cells


Gene names: FLVCR1, FLVCR
Protein names and data: FLVC1_HUMAN, Full=Feline leukemia virus subgroup C receptor-related protein 1;Short=Feline leukemia virus subgroup C receptor;Short=hFLVCR; Length: 555 a.a., Mass: 59863 Da,
fasta formatted sequence

Function: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro
Cellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Tissue specificity: Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney

Database cross-references

UniProt: Q9Y5Y0
NextBio: 51873
OMIM: 609033 609144
Ensembl: ENST00000366971
GeneCard: GC01P212858
TCDB: 2.A.1.28.1
Guide to Pharmacology: SLC49A1 (1910)
SLC49 family of FLVCR-related heme transporters (1910)

HGNC: HGNC:24682

Genetic variants

See also Ensembl:ENST00000366971