%0 Journal Article %T Putting the Pieces Together %D 2001 %R 10.1126/stke.2001.103.tw372 %J Science's STKE %P tw372-tw372 %V 2001 %N 103 %X Plants respond to light with numerous changes in developmental and physiological processes. However, the exact process by which the light signal is transduced into developmental alterations has remained obscure. Using a variety of assays in Arabidopsis, Wang et al. demonstrate a physical interaction between the blue-light photoreceptors, cryptochromes, and COP1, a ubiquitin ligase that can promote degradation of proteins by the 26S proteasome. Among the proteins that can be targeted for destruction by the proteasome is HY5, which is a transcription factor that can bind to and regulate promoters of light-inducible genes. The demonstration of a physical connection between these components helps explain the signaling pathway by which blue light affects plant growth and development. H. Wang, L.-G. Ma, J.-M. Li, H.-Y. Zha, X. W. Deng, Direct interaction of a cryptochrome with COP1 in light control development. Science 294, 154-158 (2001). [Abstract] [Full Text] %U