factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN

Plasma factor XI binds to the platelet glycoprotein Ib:IX:V complex (Baglia et al. 2002; Greengard et al. 1986). In the body, this reaction occurs specifically on the surfaces of activated platelets, but not on endothelial cells (Baird and Walsh 2002). The stoichiometry of the platelet glycoprotein Ib:IX:V complex has not been established directly, but is inferred from the relative abundances of its components in platelet membranes (Modderman et al. 1992; Shrimpton et al. 2002).

Literature References
PubMed ID Title Journal Year
12391017 Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation

Shrimpton, CN, Borthakur, G, Larrucea, S, Cruz, MA, Dong, JF, Lopez, JA

J Exp Med 2002
11696542 Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin

Baglia, FA, Badellino, KO, Li, CQ, Lopez, JA, Walsh, PN

J Biol Chem 2002
3017409 Binding of coagulation factor XI to washed human platelets

Greengard, JS, Heeb, MJ, Ersdal, E, Walsh, PN, Griffin, JH

Biochemistry 1986
1730602 Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane

Modderman, PW, Admiraal, LG, Sonnenberg, A, von dem Borne, AE

J Biol Chem 1992
Participant Of
Orthologous Events