2007 Pharmacology and Therapeutics Publications

Ailawadhi S, Nagase H, Koury T, Yu J, Tan D, Black J, Brattain M, Javle M. Intestinal trefoil factor (TFF3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma.  HepatoGastroenterology 54:1339-44, 2007.

Alagbala AA, Moser MT, Johnson CS, Trump DL, Foster BA. Characterization of vitamin D insensitive prostate cancer cells. J Steroid Biochem Mol Bio 103: 712-716, 2007.

Berger FG, Kramer DL, Porter CW. Polyamine metabolism and tumorigenesis in the ApcMin/+ mouse. Biochem. Soc. Trans, 35: 336-339, 2007.

Bihani T, Chicas A, Lo CP, Lin AW. Dissecting the senescence-like program in tumor cells activated by ras signaling. J Biol Chem., 282:2666-75, 2007.

Brooks TA, O’Loughlin KL, Minderman H, Bundy BN, Ford LA, Preibe W, Vredenburg MR, Bernacki RJ, Baer MR. The 4”-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells. Invest. New Drugs, 25: 115-122, 2007.

Brun YF, Dennis CG, Greco WR, Bernacki RJ, Pera PJ, Bushey JJ, Youn RC, White DB, Segal BH. Modeling the combination of amphotericin B, micafungin, and nikkomycin Z against Aspergillus fumigatus in vitro using a novel response surface paradigm. Antimicrobial Agents and Chemotherapy, 51: 1804-1812, 2007.

Cai S, Cannizzo F, Bullard Dunn K, Czuczman M, Gibbs JF, Rajput A. The role of surgical intervention in non-Hodgkin’s lymphoma of the colon and rectum. American Journal of Surgery, 193: 409-412, 2007.

Campbell MJ. Staying power. Nature, 446: 468, 2007.

Cano P, Godoy AS, Escamilla R, Dhir R, Onate SA. Stromal-Epithelial Cell Interactions and Androgen Receptor-Coregulator Recruitment Is Altered in the Tissue Microenvironment of Prostate Cancer. Cancer Research, 67: 511 - 519, 2007.

Chanan-Khan AA, Miller KC, Porter CW.  Bortezomib in combination with pegylated liposomal doxorubicin for the treatment of multiple myeloma.  Clin. Lymphoma & Myeloma 7: 266-71, 2007.

Chandra D, Choy G, Tang DG. Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase. Journal of Biological Chemistry, 282: 31289-31301, 2007.

Chandrasekaran EV, Xue J, Piskorz C, Locke RD, Toth K, Slocum HK, Matta KL. Potential tumor markers for human gastric cancer: an elevation of glycan : sulfotransferases and a concomitant loss of alpha 1,2-fucosyltransferase activities. Journal of Cancer Research and Clinical Oncology, 133:599-611, 2007.

Chun JY, Hu Y, Pinder E, Wu JG, Li F, Gao AC. Selenium inhibition of survivin expression by preventing Sp1 binding to its promoter. Molecular Cancer Therapeutics, 6: 2572-2580, 2007.

Chung I, Karpf AR, Muindi JR, Conroy JM, Nowak NJ, Johnson CS, Trump DL. Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol. J Biol Chem, 282: 8704-8714, 2007.

Chung I, Yu WD, Karpf AR, Flynn G, Bernardi RJ, Modzelewski RA, Johnson CS, Trump DL. Anti-proliferative effects of calcitriol on endothelial cells derived from two different microenvironments. J. Steroid Biochem Mol Bio, 103: 768-770, 2007.

Deeb KK, Johnson CS, Trump DL. Vitamin D signaling pathways in cancer: potential for anti-cancer therapeutics. Nature Reviews Cancer, 7: 684-700, 2007.

Deeb KK, Michalowska AM, Yoon C, Krummey SM, Hoenerhoff MJ, Kavanaugh C, Li M-C, Demayo FJ, Linnoila I, Deng C-X, Lee EY, Medina D, Shih JH, Green JE. Identification of an integrated SV70 T/t-antigen cancer signature in aggressive human carcinomas with poor prognosis. Cancer Res, 67: 8065-8080, 2007.

Fakih MG, Trump DL, Muindi JR, Black JD, Creaven PJ, Schwartz J, Brattain MG, Bernardi RJ, Hutson A, French R, Johnson CS. A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors. Clinical Cancer Res, 13: 1216-1223, 2007.

Fakih MG, Trump DL, Johnson CS, Tian L, Hollis B, Muindi J, Nesline M, Sunga AY. Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer. Cancer (In press).

Forouhar F, Kuzin A, Seetharaman J, Lee I, Zhou W, Abashidze M, Chen Y, Yong W, Janjua H, Fang Y, Wang D, Cunningham K, Xiao R, Acton TB, Pichersky E, Klessig DF, Porter CW, Montelione GT, Tong L. Functional insights from structural genomics. J. Struct. Funct. Genomics, 8: 37-44, 2007.

Foster J, Black J, LeVea C, Khoury T, Kuvshinoff B, Javle M, Gibbs JF.  COX-2 expression in hepatocellular carcinoma is an initiation event, while EGF receptor expression with downstream pathway activation is a prognostic predictor of survival.  Annals of Surgical Oncology 14:752-8, 2007.

Gangjee A, Zeng YB, Talreja T, McGuire JJ, Kisliuk RL, Queener SF. Design and synthesis of classical and nonclassical 6-arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as antifolates. Journal of Medicinal Chemistry, 50: 3046-3053, 2007.

Ghadersohi A, Pan D, Fayazi Z, Hicks DG, Winston JS, Li F. Prostate-derived Ets transcription factor (PDEF) downregulates survivin expression and inhibits breast cancer cell growth in vitro and xenograft tumor formation in vivo. Breast Cancer Res Treat, 102: 19-30, 2007.

Ghosh D. Review: Human sulfatases: A structural perspective to catalysis. Cell. Mol. Life. Sci., 64: 2013-2022, 2007.

Ghosh D, Griswold J, Bevilacqua T, Gonzalez-Fernandez F. Purification of the Full-length Xenopus Interphotoreceptor Retinoid Binding Protein and Growth of Diffraction-quality Crystals. Mol Vis 13: 2275-2281, 2007.

Godoy AS, Ormazabal V, Moraga-Cid G, Zúñiga FA, Sotomayor P, Barra V, Vasquez O, Montecinos V, Mardones L, Guzmán C, Villagrán M, Aguayo LG, Oñate SA, Reyes AM, Cárcamo JG, Rivas CI, Vera JC. Mechanistic Insights and Functional Determinants of the Transport Cycle of the Ascorbic Acid Transporter SVCT2: activation by sodium and absolute dependence on bivalent cations. J. Biol. Chem, 282: 615 - 624, 2007.

Gonzalez-Covarrubias V, Ghosh D, Lakhman SS, Pendyala L, Blanco JG. A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. Drug Metabolism and Disposition, 35: 973-980, 2007.

Gonzalez-Fernandez F, Baer CA, Ghosh D. Xenopus inter-photoreceptor (IRBP): structure and function. BMC Biochemistry, 8: 15, 2007.

Gonzalez-Fernandez F, Ghosh D. Focus on Molecules: Inter-photoreceptor Retinoid-Binding Protein (IRBP). Exp Eye Res, Jan 11, 2007.

Guan L, Song K, Pysz MA, Curry KJ, Hizli AA, Danielpour D, Black AR, Black JD. PKC-mediated downregulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via PI3K/Akt-independent, PP2A-dependent pathway in intestinal epithelial cells. J. Biol. Chem, 282: 14213-14225, 2007.

Guo XN, Rajput A, Rose R, Hauser J, Beko A, Kuropatwinski K, Levea C, Hoffman RM, Brattain MG, Wang J. Mutant PIK3CA-bearing colon cancer cells display increased metastasis in an orthotopic model. Cancer Research, 67: 5851-5858, 2007.

Hector S, Tummala R, Kisiel ND, Diegelman P, Vujcic S, Clark K, Fakih M, Kramer DL, Porter CW, Pendyala L. Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, t-fluorouracil and N1, N11 diethylnorspermine. Cancer Chemother Pharmacol, 2007 Nov 7; [Epub ahead of print].

Hidalgo A, Paredes R, Gardia V, Glynn G, Johnson CS, Trump DL, Onate SA. Altered VDR-mediated transcriptional activity in prostate cancer stroma. J. Steroid Biochem Mol Bio, 103: 731-736, 2007.

Ip MM, McGee SO, Masso-Welch PA, Ip C, Meng X, Ou L, Shoemaker S. The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice overexpressing erbB2 in the mammary epithelium. Carcinogenesis, 28:1269-76, 2007.

Jell J, Merali S, Hensen M, Mazurchuk R, Spernyak J, Diegelman P, Kisiel N, Barrero C, Deeb K, Patel M, Porter CW. Effect of genetically altered expression of spermidine/spermine N1-acetyltransferase on fat metabolism in mice. J. Biol. Chem., 282: 8404-8413, 2007.

Kaelin WG, Sawyers CL, Mihich E. Nineteenth Annual Pezcoller Symposium: Hypothesis-Driven Clinical Investigation in Cancer. Cancer Res 67: 11102-11105, 2007.

Karpf AR. Epigenomic reactivation screening to identify genes silenced by DNA hypermethylation in human cancer. Current Opinion in Molecular Drugs, 9: 231-241, 2007.

Kennedy D, Gawron L, Ju J, Liu W, Shen B, Beerman TA. Single chemical modifications of the enediyne core of C-1027, a radiomimetic antitumor drug, affect both drug potency and the role of Ataxia-Telangiectasia Mutated in cellular responses to DNA double strand breaks. Cancer Research, 67: 773-781, 2007.

Kennedy D, Ju J, Shen B, Beerman TA. Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses. Proc. Nat. Acad. Sci, 104: 17632-17637, 2007.

Lee WS, Choi KS, Riddell J, Ip C, Ghosh D, Park JH, Park YM. Human peroxiredoxin 1 and 2 are not duplicate proteins - The unique presence of Cys(83) in Prx1 underscores the structural and functional differences between Prx1 and Prx2. Journal of Biological Chemistry, 282: 22011-22022, 2007.

Leil TA, Endo C, Adjei AA, Dy GK, Salavaggione OE, Reid JR, Ames MM, Adjei AA. Identification and characterization of genetic variation in the folylpolyglutamate synthase gene. Cancer Research, 67: 8772-8782, 2007.

Li Y, Lin AW, Zhang X, Wang Y, Wang X, Goodrich DW. Cancer cells are uniquely dependent on Thoc1 for survival. Cancer Research, 67: 6657-6664, 2007.

Li YP, Lin AW, Zhang XJ, Wang YQ, Wang XL, Goodrich DW. Thoc1 as a potential molecular target for cancer therapy. Medicina-Buenos Aires, 67: 13-19, 2007.

Ling X, Cheng QY, Black JD, Li F. Forced expression of survivin-2B abrogates mitotic cells and induces mitochondria-dependent apoptosis by blockade of tubulin polymerization and modulation of Bcl-2 Bax and survivin. J Biol Chem, 282: 27204-27214, 2007.

Liu S, Foster BA, Chen T, Zheng G, Chen A. Modifying dendritic cells via protein transfer for antitumor therapeutics. Clinical Cancer Res, 13: 283-291, 2007.

Lotan TL, Lyon M, Huo D, Taxy JB, Brendler C, Foster BA, Stadler W, Rinker-Schaeffer CW. Upregulation of MKK4, MKK6 and MKK7 During Prostate Cancer Progression: An Important Role for SAPK Signaling in Prostatic Neoplasia. J Pathology, 212: 386-394, 2007.

Mercader M, Sengupta S, Bodner BK, Manecke RG, Cosar EF, Moser MT, Ballman KV, Wojcik EM, Kwon ED. Early effects of pharmacological androgen deprivation in human prostate cancer. BJU Int., 1: 60-67, 2007.

Mihich E. Anticancer drug-induced immunomodulation and cancer therapeutics. Curr Ca Ther Rev, 3: 174-193, 2007.

Mihich E. New directions in cancer management - Introduction. Medicina-Buenos Aires, 67: 2-2, 2007.

Montecinos V, Guzman P, Barra V, Villagran M, Munoz-Montesino C, Sotomayor K, Escobar E, Godoy AS, Mardones L, Sotomayor P, Guzman C, Vasques O, Gallardo V, van Zundert B, Bono MR, Onate SA, Bustamante M, Carcamo JG, Rivas CI, Vera JC. Vitamin C Is an Essential Antioxidant That Enhances Survival of Oxidatively Stressed Human Vascular Endothelial Cells in the Presence of a Vast Molar Excess of Glutathione. J. Biol. Chem, 282: 15506-15515, 2007.

Muindi JR, Peng Y, Wilson JW, Cappozolli MJ, Cannon YM, Johnson CS, Branch RA, Trump DL. Monocyte fructose 1,6-bisphosphatase activity: a sensitive measure of calcitriol status and effects in cancer patients. Cancer Chemother Pharmacol, 59: 97-104, 2007.

Muindi J, Nganga A, Engler K, Coignet L, Johnson C, Trump D. CYP24 splicing variants are associated with different patterns constitutive and calcitriol-inducible CYP24 activity in human prostate cancer cell lines. J. Steroid Biochem Mol Bio, 103: 334-337, 2007.

Ou L, Ip C, Lisafeld B, Ip MM. Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss. Biochem. Biophys. Res. Comm., 356: 1044-1049, 2007.

Rai K, Chidester S, Zvala CV, Manos EJ, James SR, Karpf AR, Jones DA, Cairns BR. Dnmt2 functions in the cytoplasm to promote liver, brain and retina development in zebrafish. Genes and Development, 21: 261-266, 2007.

Rajput A, Koterba AP, Kreisberg JI, Foster JM, Willson JKV, Brattain MG. A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo. Cancer Res, 67: 665-673, 2007.

Russell JS, McGee SO, Ip MM, Masso-Welch PA. Conjugated linoleic acid induces mast cell recruitment during mouse mammary gland stromal remodeling. J. Nutr., 137: 1200-1207, 2007.

Sayeed A, Konduri SD, Liu W, Bansal S, Li F, Das GM. Estrogen receptor inhibits p53-mediated transcriptional repression: Implications for the regulation of apoptosis. Cancer Res, 67: 7746-7755, 2007.

Schild SE, Bonner JA, Hillman S, Kozelsky TF, Vigliotti APG, Marks RS, Graham DL, Soori GS, Kugler JW, Tenglin RC, Wender DB, Adjei A. Results of a phase II study of high-dose thoracic radiation therapy with concurrent cisplatin and etoposide in limited-stage small-cell lung cancer (NCCTG 95-20-53). Journal of Clinical Oncology, 25: 3124-3129, 2007.

Townsend K, Trevino V, Falciani F, Stewart PM, Hewison M, Campbell MJ. Identification of VDR responsive gene signatures in breast cancer cells. Oncology, 71: 111-123, 2007.

Varma R, Hector S, Greco WR, Clark K, Hawthorn L, Porter C, Pendyala L. Platinum drug effects on the expression of genes in the polyamine pathway: time-course and concentration-effect analysis based on Affymetrix gene expression profiling of A2780 ovarian carcinoma cells. Cancer Chemother Pharmacol, 59:711-723, 2007. 

Wang J, Kuropatwinski K, Hauser J, Rossi MR, Zhou Y, Conway A, Kan JLC, Gibson NW, Willson JKV, Cowell JK, Brattain MG. Colon carcinoma cells harboring PIK3CA mutations display growth factor independence and resistance to growth factor deprivation induced apoptosis. Mol Cancer Ther, 6: 1143-1150, 2007.

Wang RW , Brattain MG. The maximal size of protein to diffuse through the nuclear pore is larger than 60 kDa. Febs Letters, 581: 3164-3170, 2007.

Wang X, Li Y, Goodrich DW. An allelic series for studying the function of Thoc1 in the mouse. Genesis, 45: 32-37, 2007.

Woloszynska-Read A, James SR, Link PA, Yu J, Odunsi K, Karpf AR. DNA methylation-dependent regulation of BORIS/CTCFL expression in ovarian cancer. Cancer Immunity, 7: 21, 2007.

Wu J, Apontes P, Song L, Liang P, Yang L, Li F. Molecular mechanism of upregulation of survivin transcription by the AT-rich DNA-binding antitumor agent, Hoechst33342: evidence for survivin involvement in drug resistance. Nucleic Acids Res, 35:2390-402, 2007.

Zahedi K, Bissler JJ, Wang Z, Josyula A, Lu L, Diegelman P, Kisiel N, Porter CW, Soleimani M.  Spermidine/spermine N1-acetyltrasferase over-expression in kidney epithelial cells disrupts polyamine homestasis, leads to DNA damage and causes G2 arrest.  Am. J. Cell Physiol, 292:C1204-15, 2007.

Zhang J, Warren MA, Shoemaker SF, Ip MM. NFκB1/p50 is not required for TNF-stimulated growth of primary mammary epithelial cells: implications for NFκB/p52 and relB. Endocrinology, 148: 268-278, 2007.