Signal recognition particle, SRP14 subunit (IPR003210)

Short name: Signal_recog_particle_SRP14

Overlapping homologous superfamilies

Family relationships




This entry represents the 14kDa SRP14 component. Both SRP9 and SRP14 have the same (beta)-alpha-beta(3)-alpha fold. The heterodimer has pseudo two-fold symmetry and is saddle-like, consisting of a curved six-stranded beta-sheet that has four helices packed on the convex side and an exposed concave surface lined with positively charged residues. The SRP9/SRP14 heterodimer is essential for SRP RNA binding, mediating the pausing of synthesis of ribosome associated nascent polypeptides that have been engaged by the targeting domain of SRP [PMID: 7730321].

GO terms

Biological Process

GO:0006614 SRP-dependent cotranslational protein targeting to membrane

Molecular Function

GO:0008312 7S RNA binding
GO:0030942 endoplasmic reticulum signal peptide binding

Cellular Component

GO:0005786 signal recognition particle, endoplasmic reticulum targeting

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.