


Sermorelin is a synthetic product that encourages natural production of growth hormone from a pituitary gland. Growth Hormone is produced in the pituitary gland and critical for growth development in children.  Human Growth Hormone, or HGH has been used to supplement a lack of Growth Hormone in children or Adults with Growth Hormone Deficiency.  Sermorelin is similar in that it is a secretogue that stimulates natural production of growth hormone form ones own pituitary gland.   Both Sermorelin and HGH require a physicians prescription.


Scientifically, Sermorelin is growth hormone releasing factor 1–29 NH2-acetate.  It is actually a peptide with the first 29 amino acids of growth hormone.   This is why Sermorelin causes growth hormone to be secreted from the pituitary gland and is called a secretogue (similar to HCG and testosterone).  For this reason, Sermorelin is considered a stimulator of HGH and while not as powerful as supplementing extra growth hormone it is a healthier alternative than HGH since it encourages natural and healthy pituitary function.  

Sermorelin and HGH Prescribing Differences

HGH is a Class 3 controlled substance and is required to be used by children with human growth hormone deficiency or Adults with Adult Growth Hormone Deficiency.  It is also a popular treatment for HIV patients.  

Growth hormone (GH) or somatotropin secreted by the pituitary gland. Growth hormone-releasing hormone (GHRH) stimulates anterior pituitary gland to release GH. The target of Growth hormone:  adipose tissue, liver, bone and muscle


Sermorelin is not a controlled substance but still a pharmaceutical requiring a physicians prescription.  It is often prescribed with growth hormone releasing peptides like GHRP-2 and GHRP-6.  hGH also is incredibly expensive and typically costs more than $1,000 per month.  Sermorelin is less than half the price of HGH.







Sermorelin and Brain Health

Sermorelin action to encourage pituitary gland activity is increasingly being prescribed to assist with TMI (Traumatic brain Injury) and brain health.   See our blog on this topic: Sermorelin and Brain Health   Sermorelin for brain performance


Benefits of Sermorelin

Let’s look at the issues caused by a decline in hGH decline and how hGH improvement effects those symptoms (Here’s an article on the benefits of HGH):

1. Body Composition

Low amounts of hGH typically sees a decrease in lean body mass (muscle) and an increase in fat mass. Correcting hGH levels has been shown to improve muscle mass and reducing fat.

2. Bone Mineral Density

HGH deficiency contributes to a loss of bone density increasing the risk of osteoporosis. Sermorelin’s increase in hGH, for greater than 12 months, improves bone mineral density and lowers the risk of osteoporosis.

3. Muscle Strength

Sermorelin and improved hGH corrects body composition and improves muscle mass and strength. Best results are after 12 months of therapy.

4. Joint Health

By improving bone mineral density and increasing muscle mass and strength, one can prevent joint deterioration that is a feature of arthritis. Optimal growth hormone levels are also essential for connective tissue in joints.

5. Exercise Performance

Exercise performance is reduced due bone density and muscle mass issues but also due to a reduction in oxygen uptake. 

6. Heart Health

There is greater heart disease risk in individuals with growth hormone deficiency due to a greater premature atherosclerosis risk (plaque inside the arteries increasing risk of heart attack and stroke). 

7. Metabolism

Growth hormone deficiency lowers resting metabolism.  hGH therapy has also been shown to increase protein synthesis, increase fat oxidation, normalize carbohydrate metabolism and reduce LDL (bad) cholesterol. 

8. Skin Thickness

Sermorelin reverses the reduction in skin thickness, and all-important skin collagen, seen in growth hormone deficiency. 

9. Immune Function

Although adults with growth hormone deficiency are not normally considered to have a compromised immune system, there is some evidence to suggest that hGH therapy can help regulate immune function.

10. Libido

People with growth hormone deficiency have increased difficulty with sexual relationships and lower energy levels. Sermorelin patients have seen an improvement in energy, libido and sexual performance.  Some men claim fewer issues with premature ejaculation.

11. Quality of Life

Reduced psychological well-being has been reported in individuals with growth hormone deficiency.  Sermorelin has resulted in improvements in mood, energy and general feelings of well-being.


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