RT Journal Article SR Electronic T1 Animal Models for Studying Female Genital Tract Infection with Chlamydia trachomatis JF Infection and Immunity JO Infect. Immun. FD American Society for Microbiology SP 3060 OP 3067 DO 10.1128/IAI.00357-13 VO 81 IS 9 A1 De Clercq, Evelien A1 Kalmar, Isabelle A1 Vanrompay, Daisy A2 Maurelli, A. T. YR 2013 UL http://iai.asm.org/content/81/9/3060.abstract AB Chlamydia trachomatis is a Gram-negative obligate intracellular bacterial pathogen. It is the leading cause of bacterial sexually transmitted disease in the world, with more than 100 million new cases of genital tract infections with C. trachomatis occurring each year. Animal models are indispensable for the study of C. trachomatis infections and the development and evaluation of candidate vaccines. In this paper, the most commonly used animal models to study female genital tract infections with C. trachomatis will be reviewed, namely, the mouse, guinea pig, and nonhuman primate models. Additionally, we will focus on the more recently developed pig model.