TY - JOUR T1 - Notch signaling: control of cell communication and cell fate JF - Development JO - Development SP - 965 LP - 973 DO - 10.1242/dev.01074 VL - 131 IS - 5 AU - Lai, Eric C. Y1 - 2004/03/01 UR - http://dev.biologists.org/content/131/5/965.abstract N2 - Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns. ER -