Why You Should Listen

In this episode, you will learn about mast cell activation syndrome (MCAS) and some key considerations when treating this common issue seen in those with Lyme disease, mold illness, autism, and other complex conditions.

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About My Guest

My guest for this episode is Dr. Theo Theoharides.  Dr. Theo Theoharides, PhD, MD has studied the regulation of mast cell activation and its role in neuroinflammatory disease for over 30 years. He holds a Masters in Neuroimmunology, a PhD in Pharmacology, and an MD from Yale University.  He was the first to report that mast cells can secrete specific mediators selectively without degranulation, regulate blood-brain-barrier permeability, stimulate microglia, be activated by corticotropin-releasing hormone (CRH) secreted under stress to release VEGF selectively, be activated by synergistic action of CRH and neurotensin, be activated by IL-33 and substance P synergistically to secrete the pro-inflammatory cytokine TNF, secrete mitochondrial DNA extracellularly that is mistaken by the body as a pathogen resulting in inflammatory reactions, and communicate with microglia and are involved in inflammation of the brain.  He discovered that mast cells are inhibited by certain natural flavonoids, especially luteolin and tetramethoxyluteolin.  He has published over 400 peer-reviewed papers and is in the top 5% of authors cited in pharmacological and immunological journals.  He is the developer of the well-known liposomal mast cell blocking nutritional supplement known as NeuroProtek and several other products.

Key Takeaways

  • What is the difference between mastocytosis and mast cell activation syndrome (MCAS)?
  • What are some conditions where MCAS may play a role?
  • What are some of the common symptoms of mast cell activation?
  • How do temperature or season changes impact symptoms?
  • What are the common triggers of MCAS?
  • What role does stress play in triggering mast cells?
  • What are the best ways to approach testing for MCAS?
  • Can Lyme disease itself be a trigger for mast cells?
  • What is the link between MCAS and brain fog?
  • What role does leaky gut play in MCAS?
  • How do EMFs impact mast cells?
  • What treatment options might be appropriate in MCAS?

Connect With My Guest


Related Resources

Algonot (NeuroProtek)

My Mystery Symptoms and Mast Cells Video

Lecture with Dr. Theo

Donate to Support Dr. Theo's Work

Interview Date

January 29, 2018 



