What is PAH?

Pulmonary arterial hypertension (PAH) is high blood pressure in the arteries of your lungs.1 It's a serious condition that can make it difficult for blood to flow through your lungs. This can force your heart to work harder.2

PAH is a chronic and progressive disease. This means that over time, PAH will get worse.2

PAH is a rare disease and not all causes are known.2 While PAH can affect people at any age, the average patient is diagnosed in their late 40s. And although anyone can develop PAH, it affects almost 4 times as many women as men.3

How PAH affects the arteries of your lungs and the heart

PAH involves a change in the levels of several natural chemicals in your blood. Over time, this can cause the arteries in your lungs to become thick and stiff.4* These changes make it difficult for blood to flow. As a result, your heart must work harder to pump blood from the right side of your heart through the arteries of your lungs.2

Healthy artery


Artery thickened as a result of PAH

What Healthy Artery Looks Like
What PAH-Affected Artery Looks Like

*Based on animal studies. The significance in humans is unknown.

Over time, this can cause the muscles of your heart to thicken. This can make it more difficult for your heart to pump blood to your body.2

Healthy heart

Heart with PAH

Healthy heart vs. PAH affected heart

Common PAH symptoms

The symptoms of PAH are similar to those of other heart and lung conditions. This may be one of the reasons why it may take a long time to get the right diagnosis.2

The most common PAH symptoms are2:

Top PAH Symptoms Image

UPTRAVI is not indicated to treat the individual symptoms of PAH, including those listed here.