TY - CHAP M1 - Book, Section TI - Chapter 12. Pharmacogenetics A1 - Shargel, Leon A1 - Wu-Pong, Susanna A1 - Yu, Andrew B.C. PY - 2012 T2 - Applied Biopharmaceutics & Pharmacokinetics, 6e AB - The genetic basis underlying variation in drug response among individuals has become evident with the introduction of modern analytical methods for the analysis of gene sequence and expression. The goal of pharmacogenetics is to stratify drug therapy into groups of individual patients based on their genetic makeup. Additional factors such as the environment, diet, age, lifestyle, and state of health can influence a person's response to medicine. An understanding of an individual's genetic makeup is thought to be the key to drug selection, drug design, and dosage regimen development. Greater efficacy and safety in drug therapy is based on stratification of patients into groups based on their relevant phenotypes (Phillips et al, 2001; Mancinelli et al, 2000). Pharmacogenetics is the study of the genetic basis of interindividual patient variability in the response to drug therapy. Pharmacogenetics allows for individualization of drug therapy. In contrast, pharmacokinetics provides a means for estimating kinetic parameters of the drug absorption, distribution, metabolism, and excretion in various population subgroups and then applying the information to drug therapy for the average patient. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2019/10/17 UR - accesspharmacy.mhmedical.com/content.aspx?aid=56604111 ER -