@article {Marti1930, author = {Marti, Matthias and Good, Robert T. and Rug, Melanie and Knuepfer, Ellen and Cowman, Alan F.}, title = {Targeting Malaria Virulence and Remodeling Proteins to the Host Erythrocyte}, volume = {306}, number = {5703}, pages = {1930--1933}, year = {2004}, doi = {10.1126/science.1102452}, publisher = {American Association for the Advancement of Science}, abstract = {To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to \~{}8\% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.}, issn = {0036-8075}, URL = {https://science.sciencemag.org/content/306/5703/1930}, eprint = {https://science.sciencemag.org/content/306/5703/1930.full.pdf}, journal = {Science} }