10 Scientifically Proven Benefits of Ozone Therapy


Ozone therapy has been in use for several decades in the United States, and much longer in European countries including Germany and Russia.

It’s one of the main therapies I used to overcome mold illness, parasites, active Epstein Barre Virus, and autoimmune disease the first time around.

It’s extremely effective against a number of ailments because of its ability to turn on your body’s self-healing mechanisms, kill living pathogens, as well as donate electrons to increase the efficiency of your cellular metabolism through bioenergetics.

You can administer or have ozone administered to you through various routes including intravenously, injection into bone or joint, rectally, vaginally, nasal insufflation and ear insufflation, as well as using it topically through steam sauna, ozonated oil, and ozonated water.

Ozone is a gas made of 3 oxygen molecules stuck together. Regular oxygen is only 2 molecules of oxygen. Due to the extra oxygen molecule, ozone is highly unstable which makes it highly reactive to blood and membranes.

Keep an eye out for my future post describing the exact mechanisms for how ozone works.

For now, though, let’s start with 10 things that ozone has been proven effective at doing!


  1. Enhances Sports Performance


Ozone works through modulation of heat shock response (HSR) to provide cytoprotection during inflammation states like strenuous physical activity1.


It also provides your cells with more mitochondrial energy through increased oxygenation2.


Not only that, but it can help heal soft tissue injuries as well as herniated discs3.


  1. Regenerates Cartilage


Which brings me to ozone’s ability to regenerate cartilage4.


A technique known as prolozone therapy has shown promise for regenerating cartilage in patients whose x-rays show little to no cartilage prior to treatment5.


This is not only beneficial for athletes, but also for those suffering from osteoarthritis, where synovial fluid is scarce, as well as degenerative disorders like ankylosing spondylitis.


  1. Kills Infections


Ozone has been used for centuries to sanitize and decontaminate water, as well as air6.


It’s one of the only compounds known to man that can neutralize a significant level of mycotoxins produced by mold.7


Ozone’s antimicrobial benefits don’t stop there, though. It’s also one of the only compounds that can inactivate a wide spectrum of virus and bacteria including HIV and MRSA. In many cases, ozone is the only compound effective against HIV and MRSA8,9,10,11,12.


Fungus, such as yeast/candida, and parasites are also killed on contact with ozone13.


Ozone in the form of ozonated water, and ozone injection is widely used in dentistry, now, to clean surgical sites and heal abscesses14.


Ozone has even been shown to heal nonhealing diabetic foot ulcers after several failed courses of treatment with antibiotics15.


  1. Repairs Nerve Damage


One of the coolest and most promising benefits of ozone therapy is its use in repairing damaged nerves.


Many degenerative and neurological disorders are hallmarked by permanent nerve damage. Chiari malformation, multiple sclerosis (MS), and sciatica are all disorders that may benefit from ozone therapy.


The research actually shows efficacy in rodent models of sciatic nerve damage as well as MS16,17.


  1. Reduces Rheumatoid Arthritis (RA) Symptoms


Rodent research has also shown improvement for RA, an auto-immune disease that involves painful, red and inflamed joints18,19.


The mechanism through which ozone helps with RA symptoms is likely 2-fold, since ozone is beneficial for osteoarthritis and auto-immune disease, alike.


  1. Auto-immune Disease


Speaking of auto-immune disease.


Ozone therapy modulates immune response through several mechanisms.


It balances immune cells, which is key for healing auto-immune disease. Ozone basically gives your body a gentle push in the right direction20,21,22.


Therefore, instead of attacking your own body, your immune system recognizes your own tissues as harmless.


  1. Helps Heal Biotoxin Illness


Similarly to auto-immune disease, innate immune dysregulation can cause major multi-system health issues.


When your body is unable to recognize antigens as harmful, those antigens can’t be readily processed out of the body through normal detoxification pathways.


The process of white blood cells capturing antigens at the receptor sites is controlled, in part, by genetics. Specifically, it’s controlled by your human leukocyte antigen (HLA) gene haplotype.


Everyone has 2 copies of the HLA gene, and therefore 2 haplotypes.


Epigenetic regulation controls which haplotype is “activated” or “turned on”.


If the haplotype that is active is one that codes for leukocytes that have wrongly-shaped antigen receptor sites, then you are likely to develop biotoxin illness as a result.


Luckily, there are environmental factors within your control that determine which haplotype is active within your personal genome.


One of those factors that effects epigenetic regulation is ozone therapy.


Ozone therapy has been shown to alter the transcription or folding of your genetic sequencing, meaning that ozone therapy can help you “turn off” your problematic genes23,24.


Once you’ve “turned off” your problematic genes, you should, theoretically, be less reactive to your environment, because you will be better able to process biotoxins effectively.


*This doesn’t mean that you should expose yourself to toxic environments once you’ve healed through ozone therapy, though. A toxic environment can also cause epigenetic changes and “turn on” those deleterious gene variants, again, if you’re exposed long enough.


  1. Activates Self-healing


Similar to how ozone can regulate your genetic expression by “turning off” your problematic genes, it can also upregulate genes that code for beneficial proteins.


The NRF2 pathway is known for its role as your self-healing mechanism.


One protein that feeds into the NRF2 pathway and helps to up-regulate it is the PGC1 alpha protein. Its production is dependent on the expression of your PGC1 alpha gene.


There are many proven ways to upregulate your self-healing genes and pathways, ozone being one of the most efficacious.


The coolest thing about ozone’s ability to promote self-healing is that it doesn’t just work through NRF2 regulation, but also simultaneously works through all of the other mechanisms mentioned in this article25,26,27.


Therefore, you can not only use ozone therapy to trigger your self-healing mechanism, if you’re chronically ill, but you can also heal through ozone’s antimicrobial and tissue regenerative mechanisms AT THE SAME TIME.


  1. Anti-aging


Again, since ozone has the ability to alter your gene expression, it also has the ability to decrease signs of aging.


Ozone can be used rectally and intravenously to slow the aging process from the inside out on a cellular level, but it can also be used topically in the form of ozonated oil.


Ozone also uses a principle known as hermetic stress to gently force your body to produce its own anti-oxidants28,29,30.


Research has shown that glutathione, your body’s number one most prevalent anti-oxidant, is increased in response to ozone therapy.


  1. Decreases Damage from Cancer Treatment


Another benefit of ozone’s ability to increase your body’s own anti-oxidant defense is that it can lessen the deleterious effects of cancer treatment.


Studies show ozone, in conjunction with traditional cancer treatment therapies including chemotherapy, can significantly improve the outcome of treatment31,32.


There are no studies, yet, supporting the hypothesis that ozone therapy, alone, is efficacious in the treatment of cancer, though.


To Recap

Ozone can be used to treat or enhance the body in many different ways through many different modalities.

It has been proven to kill some pretty nasty germs that nothing else will.

It can enhance virtually any other treatment modality if used in conjunction, including traditional cancer treatments like chemotherapy.

Ozone can also make your body younger, faster, more resilient, and just generally more efficient from a cellular level.

Like I mentioned at the beginning of this post, stay tuned for the more technical post I’m working on that describes the biochemical and bioenergetic mechanisms of how exactly ozone is believed to work.

If you enjoy this content, let me know by following my Instagram @Experimental_Betty or my Facebook page by the same name.

My IG story and IG TV channel found on my Instagram profile is where you can watch live and pre-recorded videos of me administering ozone therapy to myself, at home, in a variety of ways.

You can also find me on Youtube through the icon link to the side of this page!




  1. http://www.triroc.com/sunnen/topics/sars.html
  2. https://www.ncbi.nlm.nih.gov/pubmed/17372841/
  3. https://www.ncbi.nlm.nih.gov/pubmed/29152215
  4. https://www.ncbi.nlm.nih.gov/pubmed/29736142
  5. https://www.ncbi.nlm.nih.gov/pubmed/22470237/
  6. https://www.ncbi.nlm.nih.gov/pubmed/28515631
  7. https://www.ncbi.nlm.nih.gov/pubmed/1717074/
  8. https://www.ncbi.nlm.nih.gov/pubmed/1805686/
  9. https://www.ncbi.nlm.nih.gov/pubmed/17006820
  10. https://www.ncbi.nlm.nih.gov/pubmed/23809152/
  11. https://www.ncbi.nlm.nih.gov/pubmed/29414657
  12. https://www.ncbi.nlm.nih.gov/pubmed/16198334/
  13. https://www.ncbi.nlm.nih.gov/pubmed/18926308/
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312702/
  15. http://www.triroc.com/sunnen/topics/sars.html
  16. https://www.ncbi.nlm.nih.gov/pubmed/19342147/
  17. https://www.ncbi.nlm.nih.gov/pubmed/29152215
  18. https://www.ncbi.nlm.nih.gov/pubmed/9636722/
  19. https://www.ncbi.nlm.nih.gov/pubmed/19100257/
  20. https://www.ncbi.nlm.nih.gov/pubmed/15570426/
  21. https://www.ncbi.nlm.nih.gov/pubmed/29736142
  22. https://www.ncbi.nlm.nih.gov/pubmed/8692040/
  23. https://www.ncbi.nlm.nih.gov/pubmed/25218903/
  24. https://www.ncbi.nlm.nih.gov/pubmed/21258872/
  25. https://www.ncbi.nlm.nih.gov/pubmed/17927680/
  26. https://www.ncbi.nlm.nih.gov/pubmed/21194351/
  27. https://www.ncbi.nlm.nih.gov/pubmed/25218903/
  28. https://www.ncbi.nlm.nih.gov/pubmed/25699252/
  29. https://www.ncbi.nlm.nih.gov/pubmed/22470237/
  30. https://www.ncbi.nlm.nih.gov/pubmed/26161005/
  31. https://www.ncbi.nlm.nih.gov/pubmed/27028056/
  32. https://www.ncbi.nlm.nih.gov/pubmed/21194351/
  33. https://www.ncbi.nlm.nih.gov/pubmed/15770045/
  34. https://www.ncbi.nlm.nih.gov/pubmed/11213910/

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