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Identifying Vulnerabilities in Fungal Pathogens Through Functional and Chemical Genomic Analysis

Intrinsic and acquired drug resistance of microbial pathogens poses a grave threat to human health and has enormous economic consequences worldwide. Fungal pathogens present a particular challenge because they are eukaryotes and share many of the same biological processes as the human hosts they infect. The number of drug classes that have distinct targets in fungi is very limited and the...

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