This report argues that truly major advances in the fight against cancer, dementia and diseases of aging, still rampant infectious disease, and a host of other pressing health challenges will only come from a novel research strategy that integrates biomedical knowledge with advanced engineering skills and expertise from physical, computational, and mathematical sciences, an approach known as Convergence.

An earlier 2011 report made the case that Convergence would be important for health science research. This report goes much further, both in documenting the breadth of opportunities with huge payoffs now visible and in outlining a comprehensive research strategy to achieve them.