When Dolly was cloned, it was not from a totipotent cell in an early embryo but a G0 phase induced cell originating from the donor sheep's mammary glands. I have found sources stating that a fully differentiated cell was induced into the G0 phase by serum-starvation but couldn't find any further information on what happens inside the serum-starved cell that arrests it in the G0 phase.

Question: What is the cellular response mechanism behind serum-starvation induced G0 phase arrest? and How is it that this fully grown cell(even though it may be in G0 phase) or rather the chromosomes in that cell behave like a totipotent cell and divide to form a complete embryo when the nucleus is injected into an egg cell with the nucleus removed?


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