Trifexis Vs Advantage Multi for Dogs and Cats


Which Flea Drop is Best for Your Pet?

There are a ton of flea drops on the market that claim to be safe and effective for killing fleas but it’s hard to determine truth from hype.

That’s what we’re here for. Today we’re going to compare two of the top flea drops, Trifexis and Advantage Multi, so that you can make an informed decision.

What Do They Claim?

Advantage Multi is only available out a prescription and has two active ingredients: imidacloprid and moxidectin. Imidacloprid is a neurotoxin that protects against fleas and lice. Moxidectin is a neurotoxin that protects against heartworms, hookworms, roundworms and ear mites. There are no repellent properties in it.

Trifexis is a chewable tablet that contains milbemycin oxime and spinosad. Mibemycin oxime is a neurotoxin that acts to kill heartworms, roundworms, hookworms and pinworms by killing the juvenile parasites in the blood stream. It may also be partially effective at killing flea eggs and larvae. Spinosad is a neurotoxin that kills adult fleas. It has no repellant properties either.

Both tablets last for 30 days so they’re equal there.

Side Effects and Warnings

Trifexis and Advantage Multi carry similar warnings though spinosad is pretty well known for causing vomiting so the Advantage Multi may edge ahead just a bit there. Other side effects are rare and include drooling, nausea, skin irritation, drowsiness, depression diarrhea, loss of appetite and neurological problems such as seizures.


There are only two differences between Trifexis and Advantage Multi:

  1. Trifexis has an ingredient that may be at least moderately effective at killing juvenile fleas and eggs whereas Advantage Multi does not.
  2. Spinosad may be a bit more likely to cause vomiting. This is pretty easy to avoid if you feed your dog or cat when you give the pill.

If you’re using a product that contains Spinosad, you shouldn’t use any product containing ivermectin because there’s a history of drug interaction there.

Basically, both flea contro pills are safe and effective for your dog or cat; the decision is now up to you.

If you’ve used Advantage Multi or Trifexis, please tell us about your experience in the comments section below!

One Response to “Trifexis Vs Advantage Multi for Dogs and Cats”
  1. Ellen Allemand says:

    I have had both of my dogs, ages 3 and 8 on Trifexis for 3 years.
    This year they BOTH tested positive for heartworms. Looking for a new med, they are still on Trifexis, in hopes of slowly killing the heartworms.

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