Broadcast Date: March 24, 2020
Time: 8:00 am PT, 11:00 am ET, 16:00 CET



In this GEN webinar we will discuss how dynamic light scattering (DLS) and multi-angle light scattering combined with size exclusion chromatography (SEC-MALS) or field-flow fractionation (FFF-MALS) characterize AAV, LV, and other gene delivery vectors. Biophysical properties and attributes covered by these techniques include size, concentration, aggregation, stability and capsid content. Additionally, this webinar will provide three key learning objectives:

• How DLS screens viral vectors for size distribution, aggregation, particle concentration, and stability

• How SEC-MALS quantifies three critical quality attributes (CQAs) of AAV samples: particle titer, capsid content, and aggregation

• How FFF-MALS characterizes and quantifies large viral vectors (e.g. LVs) and other DNA/RNA delivery vehicles (e.g. lipid nanoparticles)




Produced with support from:

Wyatt Technology



Michelle Chen, PhD

Michelle Chen, PhD
Vice President of Analytical Services
Wyatt Technology