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iPSCs Reduce Pulmonary Endothelial Leakage

Induced pluripotent stem cells (iPSCs) significantly diminish the severity of endotoxin‐induced acute lung injury (ALI); however, the interactions that occur between iPSCs and the vascular endothelium remain unclear. Fortunately, a STEM CELLS study led by Kuang-Yao Yang (Taipei Veterans General Hospital, Taipei, Taiwan) recently revealed that iPSCs reduce pulmonary endothelial leakage by reversing the LPS‐induced suppression of VE‐cadherin expression. Su et al. also provide evidence that iPSCs downregulate the expression of pFAK‐Tyr397 and Snail via TIMP‐1 in LPS‐induced ALI.