BEGIN:VCALENDAR VERSION:2.0 PRODID:-// BEGIN:VTIMEZONE TZID:Europe/London BEGIN:DAYLIGHT TZOFFSETFROM:+0000 TZOFFSETTO:+0100 TZNAME:BST DTSTART:19700329T010000 RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=-1SU END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0100 TZOFFSETTO:+0000 TZNAME:GMT DTSTART:19701025T020000 RRULE:FREQ=YEARLY;BYMONTH=10;BYDAY=-1SU END:STANDARD END:VTIMEZONE BEGIN:VEVENT CATEGORIES:MRC LMB Seminar list SUMMARY:Crick Lecture 2014: How Aneuploidy Drives Cancer - Stephen Elledge\, Gregor Mendel Professor of Gene tics\, Department of Genetics\, Harvard Medical Sc hool DTSTART;TZID=Europe/London:20140919T161500 DTEND;TZID=Europe/London:20140919T180000 UID:TALK52783AT URL: DESCRIPTION:Aneuploidy has been recognized as a hallmark of ca ncer for over 100 years\, yet no general theory to explain the recurring patterns of aneuploidy in c ancer has emerged. We developed Tumor Suppressor a nd Oncogene (TUSON) Explorer\, a computational met hod that analyzes the patterns of mutational signa tures in tumors and predicts the likelihood that a ny individual gene functions as a tumor suppressor (TSG) or oncogene (OG). By analyzing >8200 tumor- normal pairs we provide statistical evidence sugge sting many more genes possess cancer driver proper ties than anticipated\, forming a continuum of onc ogenic potential. Integrating our driver predictio ns with information on somatic copy number alterat ions\, we find that the distribution and the poten cy of TSGs (STOP genes)\, OGs and essential genes (GO genes) on chromosomes can predict the complex patterns of aneuploidy and copy number variation c haracteristic of cancer genomes. We propose that t he cancer genome is shaped through a process of cu mulative haploinsufficiency and triplosensitivity. We are now assessing how aneuploidy drives cancer and the potency with which it does so. Ramificat ions of aneuploidy will be discussed. LOCATION:Max Perutz Lecture Theatre\, Medical Research Coun cil (MRC) (MRC Laboratory of Molecular Biol CONTACT:Scientific Meetings Co-ordinator END:VEVENT END:VCALENDAR