%0 Journal Article %A Cheever, Allen W. %A Deb, Subrato %A Duvall, Rodney H. %T Granuloma Formation in Schistosoma japonicum Infected Nude Mice: the Effects of Reconstitution with L3T4+ or Lyt2+ Splenic Cells %D 1989 %J The American Journal of Tropical Medicine and Hygiene, %V 40 %N 1 %P 66-71 %@ 0002-9637 %R https://doi.org/10.4269/ajtmh.1989.40.66 %I The American Society of Tropical Medicine and Hygiene, %X Abstract The role of L3T4+ and Lyt2+ lymphocytes in the formation and modulation of granulomas around Schistosoma japonicum eggs was examined in athymic mice. Nude C57BL/6 mice infected with S. japonicum miracidia were compared to nude mice given normal spleen cells depleted of L3T4+ or Lyt2+ cells prior to infection and to intact mice. Nude mice formed small granulomas that were poor in eosinophils and connective tissue. Nude mice reconstituted with cells enriched for L3T4+ or Lyt2+ cells formed granulomas similar in size to those in intact mice, but granulomas in mice given Lyt2+ cells contained few eosinophils and had significantly less collagen than did granulomas in mice given L3T4+ cells. The same was true at 10 weeks. Mice reconstituted with null cells were examined at 7 weeks and formed granulomas similar to those in mice given Lyt2+ cells. By 10 weeks after infection, granulomas had decreased to the same minute size in all groups of mice. Fibrosis increased at weeks 7–10 in all groups of mice. %U http://www.ajtmh.org/content/journals/10.4269/ajtmh.1989.40.66