abraxas 1, BRCA1 A complex subunit

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA281 Skin, Lung Human YES

GO terms:

Biological Process:
DNA repair [GO:0006281],
double-strand break repair [GO:0006302],
chromatin organization [GO:0006325],
cellular response to DNA damage stimulus [GO:0006974],
attachment of spindle microtubules to kinetochore [GO:0008608],
response to ionizing radiation [GO:0010212],
positive regulation of DNA repair [GO:0045739],
protein K63-linked deubiquitination [GO:0070536],
signal transduction involved in G2 DNA damage checkpoint [GO:0072425],
mitotic spindle assembly [GO:0090307],
double-strand break repair via nonhomologous end joining [GO:0006303],
protein deubiquitination [GO:0016579],

Molecular Function:
microtubule binding [GO:0008017],
polyubiquitin binding [GO:0031593],
protein binding [GO:0005515],

Cellular Component:
nucleus [GO:0005634],
nuclear body [GO:0016604],
BRCA1-A complex [GO:0070531],
nucleoplasm [GO:0005654],