start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=4 article-no= start-page=223 end-page=227 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Elevated Lipid Peroxidation, Decreased Glutathione Levels and Changes in Glutathione-Related Enzymes in Rats Treated with Human PIacental Extract en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The in vivo effects of human placental extract (1-4 ml/kg) on hepatic lipid peroxidation, blood and liver glutathione (GSH) levels and several enzymes associated with the antioxidant defence mechanism; i.e., catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase, together with some blood biochemical responses were investigated in rats. At an optimal dose level (4 ml/kg), a single acute intraperitoneal administration of the extract caused a significant enhancement (49.9%; p < 0.001) of lipid peroxidation with a decline in GSH level both in blood (45.1%; p < 0.001) and liver (61.0%; p < 0.001) in comparison to control animals. Activities of catalase, glutathione peroxidase and glutathione reductase were inhibited in a dose-responsive way by the treatment with the extract which also increased the activity of glutathione S-transferase in a dose-dependent manner. The extract was found to be hepatotoxic in terms of elevation of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum lactate dehydrogenase and blood methemoglobin concentration. Results of this study suggest the adverse consequences of the administration of the extract due to its substantial ability to alter normal cellular processes.

en-copyright= kn-copyright= en-aut-name=BanerjeeKishore Kumar en-aut-sei=Banerjee en-aut-mei=Kishore Kumar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=BishayeeAnupam en-aut-sei=Bishayee en-aut-mei=Anupam kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ChatterjeeMalay en-aut-sei=Chatterjee en-aut-mei=Malay kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Jadavpur University affil-num=2 en-affil= kn-affil=Jadavpur University affil-num=3 en-affil= kn-affil=Jadavpur University en-keyword=human placental extract kn-keyword=human placental extract en-keyword=lipid peroxidation kn-keyword=lipid peroxidation en-keyword=antioxidant defence components kn-keyword=antioxidant defence components en-keyword=hepatotoxicity kn-keyword=hepatotoxicity END