Description and Brand Names

Drug information provided by: IBM Micromedex

US Brand Name

  1. Repatha


Evolocumab injection is used together with a proper diet, alone or together with other medicines (eg, ezetimibe, statins), to treat patients with heterozygous familial hypercholesterolemia (also called primary hyperlipidemia) or with homozygous familial hypercholesterolemia (HoFH), who need additional lowering of their LDL cholesterol. It is also used in patients with a heart and blood vessel disease to reduce the risk of heart attack, stroke, and certain types of heart surgery. This medicine is a PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Solution

Before Using





Appropriate studies have not been performed on the relationship of age to the effects of evolocumab injection in the pediatric population. Safety and efficacy have not been established in children younger than 13 years of age with HoFH, and in children with primary hyperlipidemia.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of evolocumab injection in the elderly. However, elderly patients are more sensitive to the effects of this medicine than younger adults.



Drug Interactions



  • Tofacitinib

Other Interactions


Proper Use


This medicine comes with a patient information leaflet and patient instructions. Read instructions before starting this medicine and with each refill. New information may be given. Follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.


This medicine comes in 3 forms: a single-dose prefilled pen (autoinjector), single-dose prefilled syringe, and a single-use Pushtronex™ system (on-body infusor with prefilled cartridge). Your doctor will prescribe the type and dose that is right for you.


Do not inject on skin areas that have cuts, scrapes, infection, scars, or stretch marks.

If you are receiving the 420 milligrams (mg) dose of Repatha®, it can be given by: over 9 minutes by using the single-use Pushtronex™ system, or by 3 injections consecutively within 30 minutes using the single use prefilled syringe or autoinjector.

The autoinjector pen or prefilled syringe should be removed from the refrigerator and be allowed to reach room temperature for at least 30 minutes before using, or for at least 45 minutes for single-use Pushtronex™ system. Do not shake the medicine.






  • For injection dosage form:
    • For primary hyperlipidemia:
      • Adults—140 milligrams (mg) injected under your skin every 2 weeks, or 420 mg injected under your skin once a month.
    • For homozygous familial hypercholesterolemia:
      • Adults and children 13 years of age and older—420 milligrams (mg) injected under your skin once a month.
    • To reduce the risk of heart attack, stroke, and heart surgery:

Missed Dose


If you missed a dose, use this medicine within 7 days from the missed dose. Then, resume your original schedule.

If it is more than 7 days from your missed dose and you are using an every-2-week-dose: Inject the dose based on your regular schedule.

If it is more than 7 days from your missed dose and you are using a once-a-month-dose: Inject the dose and start a new schedule using this date.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.


Store in the refrigerator. Do not freeze.

You may also keep the medicine in the original carton at room temperature for up to 30 days. Throw away any unused medicine within 30 days.



It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly to lower your cholesterol level and to decide if you should continue to use it. Blood tests may be needed to check for unwanted effects.


The needle cover of the prefilled syringe or autoinjector contains dry natural rubber (a derivative of latex), which may cause allergic reactions in people who are sensitive to latex. The single use Pushtronex™ system is not made with natural rubber latex. Tell your doctor if you have a latex allergy before you start using this medicine.

Side Effects



Incidence not known

  1. Difficulty with breathing or swallowing
  2. fever
  3. hives, itching, or rash
  4. nausea
  5. reddening of the skin, especially around the ears
  6. swelling of the eyes, face, or inside of the nose
  7. unusual tiredness or weakness


More common

  1. Back pain
  3. blurred vision
  4. body aches or pain
  5. chills
  6. cough
  7. dry mouth
  8. ear congestion
  9. flushed, dry skin
  10. fruit-like breath odor
  11. headache
  12. loss of voice
  13. muscle aches
  14. sneezing
  15. sore throat
  16. stomach ache
  17. stuffy or runny nose
  18. sweating
  19. troubled breathing
  20. unexplained weight loss
  21. vomiting

Less common

  1. Bladder pain
  2. bloody or cloudy urine
  3. diarrhea
  4. difficult, burning, or painful urination
  5. difficulty with moving
  6. dizziness
  7. frequent urge to urinate
  8. loss of appetite
  9. lower back or side pain
  10. muscle or joint pain
  11. muscle stiffness
  12. nervousness
  13. pain or tenderness around the eyes and cheekbones
  14. pounding in the ears
  15. slow or fast heartbeat
  16. swollen joints

