Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide

Manhong Wu, Robert Hancock

Research output: Contribution to journalArticle

96 Citations (Scopus)


Both linear and cyclic derivatives of the cyclic 12-amino-acid antimicrobial peptide bactenecin were designed based on optimization of amphipathicity and charge location. In general, increasing the number of positive charges at the N and C termini and adding an extra tryptophan residue in the loop not only increased the activities against both gram- positive and gram-negative bacteria but also broadened the antimicrobial spectrum.

Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number5
Publication statusPublished - 1 May 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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