InterPro : IPR013760

Name  DNA topoisomerase, type IIA-like domain Short Name  Topo_IIA_like_dom
Type  Domain Description  Type IIA topoisomerases together manage chromosome integrity and topology in cells. Topoisomerase II (called gyrase in bacteria) primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2. In most eukaryotes, topoisomerase II consists of a single polypeptide, where the N- and C-terminal regions correspond to gyrB and gyrA, respectively; this topoisomerase II forms a homodimer that is equivalent to the bacterial heterotetramer. There are four functional domains in topoisomerase II: domain 1 (N-terminal of gyrB) is an ATPase, domain 2 (C-terminal of gyrB) is responsible for subunit interactions (differs between eukaryotic and bacterial enzymes), domain 3 (N-terminal of gyrA) is responsible for the breaking-rejoining function through its capacity to form protein-DNA bridges, and domain 4 (C-terminal of gyrA) is able to non-specifically bind DNA [].Topoisomerase IV primarily decatenates DNA and relaxes positive supercoils, which is important in bacteria, where the circular chromosome becomes catenated, or linked, during replication []. Topoisomerase IV consists of two polypeptide subunits, parE and parC, where parC is homologous to gyrA and parE is homologous to gyrB.This entry represents the C-terminal of subunit B (gyrB and parE) and the N-terminal of subunit A (gyrA and parC) of bacterial gyrase and topoisomerase IV, and the equivalent region in eukaryotic topoisomerase II composed of a single polypeptide.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR013759 DNA topoisomerase, type IIA, central domain Topo_IIA_cen_dom Domain

7 Contains

Id Name Short Name Type
IPR006171 Toprim domain Toprim_domain Domain
IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal Topo_IIA_A/C Domain
IPR013759 DNA topoisomerase, type IIA, central domain Topo_IIA_cen_dom Domain
IPR018522 DNA topoisomerase, type IIA, conserved site TopoIIA_CS Conserved_site
IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta Topo_IIA_A/C_ab Domain
IPR013757 Type IIA DNA topoisomerase subunit A, alpha-helical domain Topo_IIA_A_a Domain
IPR002288 DNA gyrase B subunit, C-terminal DNA_gyrase_B_C Domain

9 Found In

Id Name Short Name Type
IPR001241 DNA topoisomerase, type IIA Topo_IIA Family
IPR001154 DNA topoisomerase II, eukaryotic-type TopoII_euk Family
IPR005743 DNA gyrase, subunit A GyrA Family
IPR005740 DNA topoisomerase 4 subunit B, Gram-positive ParE Family
IPR011557 DNA gyrase, subunit B GyrB Family
IPR000565 DNA topoisomerase, type IIA, subunit B Topo_IIA_B Family
IPR005741 DNA topoisomerase IV subunit A, Gram-positive TopoIV_A_Gpos Family
IPR005742 DNA topoisomerase IV, subunit A, Gram-negative TopoIV_A_Gneg Family

0 Parent Features

2 Publications

First Author Title Year Journal Volume Pages

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