Macrolactonization Driven by Supramolecular Interactions guillaume force david leboeuf 10.26434/chemrxiv.11743017.v1 Macrolactones constitute a privileged class of natural and synthetic products with a broad range of applications in the fine chemicals and pharmaceutical industry. Despite all the progresses made towards their synthesis, notably from <i>seco</i>-acids, a macrolactonization promoter system that is effective, selective, flexible, readily available, and, insofar as possible, compatible with manifold functional groups is still lacking. Herein, we describe an alternative strategy relying on a speculated supramolecular template to enable a convenient access to macrolactones, macrodiolides and esters with a versatility that had not been reached with classic methods. 2020-01-29 05:05:02 macrolactone products macrolactonization reaction