@ARTICLE{10.3389/fchem.2020.00460, AUTHOR={Chen, Yang and Xiao, Shu and Huang, Jian and Xue, Wei and He, Shuzhong}, TITLE={A Synthetic View on Haedoxans and Related Neolignans From Phryma leptostachya}, JOURNAL={Frontiers in Chemistry}, VOLUME={8}, PAGES={460}, YEAR={2020}, URL={https://www.frontiersin.org/article/10.3389/fchem.2020.00460}, DOI={10.3389/fchem.2020.00460}, ISSN={2296-2646}, ABSTRACT={Haedoxans are a series of sesquilignan natural products isolated from the traditional insecticidal plant Phryma leptostachya. Given their significant insecticidal activity, haedoxans and related analogs have been considered as potential agents for plant defense. Moreover, these compounds also exhibit promising antifungal, antibacterial, and anticancer activities. The present paper is a review of the structure, biological activity, and chemical synthesis of naturally occurring haedoxan-like molecules.} }