kinases protein kinase inhibitors signaling activators kinase substrates antibodies bioluminescence assays
Chelerythrine Chloride, 5 mg  

Chelerythrine Chloride, 5 mg

Chelerythrine Chloride is a selective PKC inhibitor, 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c) phenanthridinium chloride

potent, cell-permeable protein kinase C inhibitor, CAS number: 3895-92-9

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Background: Chelerythrine Chloride is a potent and selective protein kinase C inhibitor (PKC, IC50 = 0.66 µM). Solubility: soluble in DMSO and water. Rather insoluble in aqueous media that contain substantial saline concentrations.

Chemical formula: C21H18NO4Cl
Molecular weight: 383.8 g/mol
Purity: >95%
Appearance: Yellow to orange solid
Solubility: soluble in DMSO and water (DMSO: ≥10 mg/mL, H2O: 5 mg/mL)
CAS number: 3895-92-9

Product specific literature references:

Herbert JM, Augereau JM, Gleye J, Maffrand JP (1990) "Chelerythrine is a potent and specific inhibitor of protein kinase C" Biochem. Biophys. Res. Commun. 172(3):993-9

Liu Y, Cohen MV, Downey JM (1994) "Chelerythrine, a highly selective protein kinase C inhibitor, blocks the anti-infarct effect of ischemic preconditioning in rabbit hearts" Cardiovasc. Drugs Ther. 8(6):881-2

Serrano PA, Rodriguez WA, Pope B, Bennett EL, Rosenzweig MR (1995) "Protein kinase C inhibitor chelerythrine disrupts memory formation in chicks" Behav. Neurosci. 109(2):278-84

Eckly-Michel AE, Le Bec A, Lugnier C (1997) "Chelerythrine, a protein kinase C inhibitor, interacts with cyclic nucleotide phosphodiesterases" Eur. J. Pharmacol. 324(1):85-8

Sacchetti B, Bielavska E (1998) "Chelerythrine, a specific PKC inhibitor, blocks acquisition but not consolidation and retrieval of conditioned taste aversion in rat" Brain Res. 799(1):84-90

Lundmark JL, Ramasamy R, Vulliet PR, Schaefer S (1999) "Chelerythrine increases Na-K-ATPase activity and limits ischemic injury in isolated rat hearts" Am. J. Physiol. 277(3 Pt 2):H999-H1006

Yu R, Mandlekar S, Tan TH, Kong AN (2000) "Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C" J. Biol. Chem. 275(13):9612-9
