Testosterone taken exogenously carries with it some significant and life-changing side effects such as infertility and life-long dependency. As a physician specializing in male reproductive medicine and male infertility for more than 20 years, I have recently come to see at least a few couples per week in my office who are dealing with the effects of infertility caused by male hormone replacement therapy.
Testosterone replacements can cause infertility and azoospermia (absence of measurable sperm). Though this condition is reversible in the vast majority of patients, there is still a small group who become permanently impaired.
Testosterone slows down the glands that work together to produce sperm. The basics of biological science clearly indicate that exogenous hormone replacement therapy has a negative effect on sperm production.

It can take 2-6 months for sperm production to reach the best levels for conception. Once testosterone replacement therapy is stopped and depending on how long and at what dosage it was taken, it can take months for sperm reserves to rebuild. Open discussion with your doctor is important. Few physicians know about the fertility side effects that can be caused by male hormone replacement therapies, so they may not bring up family planning in their discussions with you on this topic. Testosterone taken exogenously (via injection, skin patches, gels, creams or oral medications) carries with it some significant and life-changing side effects such as infertility and life-long dependency. This delay can be disastrous for women who are at the upper spectrum of their childbearing years.

Once traditional male hormone replacement therapy is stopped, the rebound to fertility can be speeded along with the use of certain medications. These medications stimulate testosterone and sperm production, thereby allowing men to get the benefits of hormone replacement therapy, without the sterilizing effects.

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