The Allergy Meds to Avoid if You Have High Blood Pressure

About one in three adults in the U.S. has high blood pressure, or hypertension — a disease in which pressure in the body’s arteries is higher than it should be. (Learn More)

Many people with high blood pressure also suffer from allergies, which occur when the body’s immune system has a hypersensitive response to a usually benign substance and releases chemicals that trigger inflammation. This results in common allergic symptoms like runny nose, watery eyes, and congestion. (Learn More)

Allergies generally don’t directly affect blood pressure, although congestion can cause or worsen sleep apnea, which can increase hypertension. (Learn More)

Before starting any medication, including allergy medication, it’s a good idea to talk with your doctor about your symptoms and concerns, particularly if you have a known history of high blood pressure. (Learn More)

If you have high blood pressure, decongestants shouldn’t be used as an allergy medication, as they may increase blood pressure and heart rate. (Learn More)

Antihistamines are considered a safer choice for those with high blood pressure. Second-generation options like Zyrtec have fewer side effects.

Combination allergy drugs that combine antihistamines and decongestants should not be used by those with hypertension. (Learn More)

Anti-inflammatories, or corticosteroids, use steroids to treat inflammation or irritation caused by allergies.

Nasal steroid sprays are generally considered safe when taken at proper doses. They are effective at treating allergic symptoms related to nasal congestion and inflammation. (Learn More)

high blood pressure

Understanding High Blood Pressure

As the heart pumps blood throughout the body, it travels through arteries. The arteries are an important part of the body’s circulation system, carrying (mostly oxygenated) blood to the tissues of the body.

The force of the blood pushing against the artery walls as blood is being pumped from the heart is called blood pressure.

High blood pressure, or hypertension, is a disease in which pressure in the body’s arteries is higher than it should be. If the blood pressure remains high for an extended period, it can lead to many health complications and problems, including heart disease, stroke, kidney failure, and vision loss.

About one in three adults in the U.S. has high blood pressure, amounting to approximately 75 million people.

Understanding Allergies

Allergies are due to the immune system having an extreme response to a substance that is normally nonthreatening.

A person can develop an allergy to a substance at any time, as their body can begin to “reject” it at any time.

Common airborne allergens are pollen, dust mites, mold, and pet dander. Latex and other materials can result in skin allergies that lead to rash and other irritations.

man allergic to dog

Can Allergies Make Hypertension Worse? 

Generally, allergies don’t directly affect blood pressure. However, nasal congestion from allergies can sometimes interfere with sleep at night, causing or worsening sleep apnea (a type of snoring that creates a gasping-for-breath sensation). This can impact blood pressure.

Sleep apnea is a serious condition. See a doctor if you suspect it may be an issue.

Talk to Your Doctor

Generally, there are three types of allergy medications: decongestants, antihistamines, and anti-inflammatories.

Before starting allergy medication, talk to your doctor. This is especially important for those with high blood pressure. Many medications, including some allergy treatments, can raise blood pressure.

Remember that many people with hypertension don’t even realize they have blood pressure issues. Check with your doctor about blood pressure, especially if you have other medical conditions or are on other medications, or if you have a family history of heart problems, diabetes, stroke, or kidney problems.


talking to doctor

If you have high blood pressure, decongestants are the type of allergy medication you want to avoid. The most common types available are phenylephrine and pseudoephedrine.

Decongestants work by narrowing the blood vessels, which reduces inflammation in the nasal passages by shrinking swollen mucous membranes. This provides relief from many allergy symptoms.

This narrowing of the blood vessels, also called vasoconstriction, can also occur throughout the body and cause an increase in blood pressure.

Decongestants can reduce the effects of hypertension medication, potentially leading to a loss of blood pressure control.

Some decongestants, particularly pseudoephedrine, may also increase heart rate and the risk of heart rhythm disturbances.

Zyrtec and Other Antihistamines

Antihistamines work by blocking the effects of histamine, an inflammation-causing substance that’s released during an allergic reaction.

Antihistamines come in many forms, including tablets, capsules, liquids, eye drops, intranasal sprays, and injections.

Antihistamines are generally considered a safer choice for those with blood pressure problems, although the U.S. Food and Drug Administration (FDA) does warn that taking certain antihistamines with medications for high blood pressure may lead to increased blood pressure and heart rate.

Although they are safer for the heart and blood pressure, antihistamines have some undesirable side effects, including drowsiness, overheating, and blurred vision. They also shouldn’t be used during pregnancy, and they can interact with other substances and drugs. 

Zyrtec is a popular over-the-counter antihistamine medicine (a brand-name version of cetirizine) and generally considered a safe choice for those with high blood pressure. Zyrtec is less likely to cause extreme drowsiness and other side effects than first-generation antihistamines. Even though Zyrtec is an over-the-counter medication, anyone with hypertension should consult with a health care provider before using it.

It’s important to note that many antihistamines come as combination drugs, often combined with a decongestant. Zyrtec-D, for example, is a combination antihistamine-decongestant drug.

Antihistamine-decongestant drugs (commonly marked with a “D” after the antihistamine name) should not be used by those with high blood pressure.

allergy medication


Anti-inflammatories, or corticosteroids, lessen swelling and pain that are due to allergies. The most common type of corticosteroids used to treat allergies are intranasal sprays, or nasal steroid sprays.

When taken properly, they have minimal side effects, though some users may experience dryness in the nose and headache. They are considered a safer option for people with high blood pressure, as long as they are taken at the proper dosage.

Taking too high of a dose of corticosteroids can result in salt and water retention, which can lead to increased blood pressure. 


What Is High Blood Pressure? (May 30, 2018). Everyday Health.

The Role of Arteries in the Circulatory System. (October 11, 2018). Verywell Health.

High Blood Pressure. (April 11, 2019). Centers for Disease Control and Prevention (CDC).

Everything You Need to Know About Allergies. (October 24, 2017). Medical News Today.

Ask the Doctor: Can Allergies Cause High Blood Pressure? (April 2010) Harvard Medical School.

Choosing an Over-the-Counter Allergy Medication. (March 2019) Harvard Medical School.

5 Surprising Facts About High Blood Pressure. (May 27, 2016). Centers for Disease Control and Prevention.

Decongestants to Treat Allergy Symptoms. (March 11, 2016). Healthline.

Dangers of Allergy Meds for Your Heart. (April 1, 2015). Everyday Health.

What Is an Antihistamine? (November 25, 2015). Everyday Health.

What Allergy Medicines Can I Safely Take if I Have Heart Disease or High Blood Pressure? (May 2018). Oklahoma Heart Institute.

Avoiding Drug Interactions. Food and Drug Administration (FDA).

Cetirizine. (March 22, 2017). Healthline.

Allergic Rhinitis. (February 6, 2018). American College of Allergies, Asthma, and Immunology (ACAAI)

Nasal Steroid Sprays for Allergies. (November 1, 2018). Verywell Health.

The Best Allergy Medicine for High Blood Pressure. (July 27, 2017). Healthfully.