Rabbit Anti-Human IFN-lambda2

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Size100 µg
Price235 €
CategoryPolyclonal Antibody
Clone Nr.Rabbit IgG
Species ReactivityHuman
Formulationlyophilized from PBS
PreparationProduced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hIFN-λ2. Anti-Human IFN-λ2 specific antibody was purified by affinity chromatography employing immobilized hIFN-λ2 matrix.
AntigenRecombinant human IFN-lambda2
ApplicationELISA, WB
SynonymsIL29; IFNL1; IL-29;
DescriptionHuman/mouse IFN-lambda 2 or IL-28A, IL-28B (or IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.
Uniprot IDQ8IZJ0
Protein RefSeqNP_742150.1
mRNA RefSeqNM_172138

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