RT Journal Article SR Electronic T1 A Novel Risk Locus at 6p21.3 for Epstein–Barr Virus-Positive Hodgkin Lymphoma JF Cancer Epidemiology Biomarkers & Prevention JO Cancer Epidemiol Biomarkers Prev FD American Association for Cancer Research SP 1838 OP 1843 DO 10.1158/1055-9965.EPI-15-0534 VO 24 IS 12 A1 Delahaye-Sourdeix, Manon A1 Urayama, Kevin Y. A1 Gaborieau, Valérie A1 Veenstra, Rianne A1 Foll, Matthieu A1 Chabrier, Amelie A1 Benavente, Yolanda A1 Nieters, Alexandra A1 Becker, Nikolaus A1 Foretova, Lenka A1 Maynadié, Marc A1 Staines, Anthony A1 Smedby, Karin Ekstrom A1 Glimelius, Ingrid A1 Lightfoot, Tracy A1 Cocco, Pierluigi A1 Galan, Pilar A1 Vatten, Lars J. A1 Duell, Eric J. A1 Kiemeney, Lambertus A1 Roman, Eve A1 de Sanjosé, Silvia A1 Lathrop, Mark A1 Melbye, Mads A1 Brennan, Paul A1 Diepstra, Arjan A1 van den Berg, Anke A1 Hjalgrim, Henrik A1 Jarrett, Ruth F. A1 McKay, James D. YR 2015 UL http://cebp.aacrjournals.org/content/24/12/1838.abstract AB Background: A proportion of the genetic variants involved in susceptibility to Hodgkin lymphoma differ by the tumor's Epstein–Barr virus (EBV) status, particularly within the MHC region.Methods: We have conducted an SNP imputation study of the MHC region, considering tumor EBV status in 1,200 classical Hodgkin lymphoma (cHL) cases and 5,726 control subjects of European origin. Notable findings were genotyped in an independent study population of 468 cHL cases and 551 controls.Results: We identified and subsequently replicated a novel association between a common genetic variant rs6457715 and cHL. Although strongly associated with EBV-positive cHL [OR, 2.33; 95% confidence interval (CI), 1.83–2.97; P = 7 × 10–12], there was little evidence for association between rs6457715 and the EBV-negative subgroup of cHL (OR, 1.06; 95% CI, 0.92–1.21), indicating that this association was specific to the EBV-positive subgroup (Phet < P = 10−8). Furthermore, the association was limited to EBV-positive cHL subgroups within mixed cell (MCHL) and nodular sclerosis subtypes (NSHL), suggesting that the association is independent of histologic subtype of cHL.Conclusions: rs6457715, located near the HLA-DPB1 gene, is associated with EBV-positive cHL and suggests this region as a novel susceptibility locus for cHL.Impact: This expands the number of genetic variants that are associated with cHL and provides additional evidence for a critical and specific role of EBV in the etiology of this disease. Cancer Epidemiol Biomarkers Prev; 24(12); 1838–43. ©2015 AACR.This article is featured in Highlights of This Issue, p. 1809