@article{SINGH_KHATIK_MISHRA_KHURANA_SHARMA_VYAS_2019, title={FORMULATION DEVELOPMENT AND IN VITRO ANTIOXIDANT AND ANTIDIABETIC EVALUATION OF ERIOBOTRYA JAPONICA BASED SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM}, volume={11}, url={https://innovareacademics.in/journals/index.php/ijap/article/view/33006}, DOI={10.22159/ijap.2019v11i4.33006}, abstractNote={<p><strong>Objective: </strong>The aim of the present study was to develop and characterize self-nano emulsifying drug delivery system (SNEDDS) of methanolic extract of <em>Eriobotrya japonica</em> (Thunb.) Lindl. (<em>E. japonica</em>) leaves. Further <em>in vitro</em> antioxidant and antidiabetic potential of an optimized batch of SNEDDS was explored.</p> <p><strong>Methods: </strong>Oil (Labrafil M 1944 CS), surfactant (Tween 80) and co-surfactant (Transcutol P) were selected on the basis of solubility of the methanolic extract. Twenty-seven batches of SNEDDS were prepared with different compositions of oil, surfactant and co-surfactant. The optimized batch was evaluated for its entrapment efficiency, droplet size, polydispersity index (PDI), zeta potential, transmission electron microscopy (TEM). Further, DPPH assay and α-amylase activity were also performed to check the antioxidant and antidiabetic potential of prepared SNEDDS.</p> <p><strong>Results: </strong>The optimized design suggested that 10% of Labrafil M 1944CS, 30% of Tween 80 and 60% of Transcutol P could develop SNEDDS with 208 nm mean droplet size, 99.64% drug loading, 0.156 PDI and-6 mV zeta potential. TEM image confirmed the droplet size less than 100 nm and the spherical shape of SNEDDS. <em>In vitro </em>antioxidant and antidiabetic activities of SNEDDS revealed the increased efficacy as compared to that of the ascorbic acid and acarbose, respectively.</p> <p><strong>Conclusion: </strong>The optimized batch of SNEDDS was found to improve the antioxidant and antidiabetic efficacy of methanolic extract of <em>E. japonica</em>.</p&gt;}, number={4}, journal={International Journal of Applied Pharmaceutics}, author={SINGH, AMRIT PAL and KHATIK, GOPAL L. and MISHRA, VIJAY and KHURANA, NAVNEET and SHARMA, NEHA and VYAS, MANISH}, year={2019}, month={May}, pages={313-319} }