Notch Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7399 FLI-06

FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.

Selective Notch, EC50: 2.3 μM
S2714 LY411575

LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with IC50 of 0.39 nM.

Pan Notch S3 cleavage, IC50: 0.39 nM
S2711 YO-01027 (Dibenzazepine)

YO-01027 (Dibenzazepine) is a dipeptidic γ-secretase inhibitor with IC50 of 2.6 nM and 2.9 nM for APPL and Notch cleavage, respectively.

Pan γ secretase(Notch), IC50: 2.9 nM
S1575 RO4929097

RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2.

Pan γ secretase(ICN), IC50: 5 nM
S1594 Semagacestat (LY450139)

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM. Phase 3.

Pan Notch, IC50: 14.1 nM