Boost Your Nitric Oxide
Levels With L-Arginine, Right?

Here's Why Arginine Is Nearly Useless For People Over 40…
Plus What MIT Researchers Say You Should Be Doing Instead

You've probably heard about nitric oxide, the molecule that improves heart health, energy levels, and sexual performance.

The most common advice is to take l-arginine to boost nitric oxide. But the fact is, it's hard for your body to turn l-arginine into nitric oxide. Especially if you're over 40.

I'll tell you more about this problem and how to solve it in a moment. But first, I'd like to tell you about some new findings on nitric oxide that will amaze you.

The Miracle Molecule

As you may know, nitric oxide is a little gas molecule produced in our bodies. It impacts the health of every cell, tissue, and organ. In fact, it is so important that the scientists who discovered what it does for us won the Nobel Prize.

And nitric oxide does a lot for us. Hundreds of studies show that nitric oxide boosts circulation … supports a healthy heart … and improves our sex lives.

These are all great benefits. So great, that based on these alone I'd urge my patients to support healthy nitric oxide levels. But nitric oxide does so much more than just support your circulatory system and improve your sex life. New research shows that nitric oxide is also…

Nature's Weapon Against "Senior Moments"

Do you ever forget where you parked your car? Walk into a room and suddenly draw a blank as to why you're there? Forget someone's name right after you meet them? Or worse, run into an old friend and stammer as you try to remember her name?

Well, here's good news! Studies show that nitric oxide improves memory, slow response and confused thinking in three ways:

  1. ✔ It helps store memories as they are created;

  2. ✔ It helps retrieve memories later on; and

  3. ✔ It helps brain cells send and receive signals more quickly.

Indeed, the brain-boosting effects of nitric oxide have been proven in before-and-after MRIs of the brain. I'll tell you more about those studies in a minute. But first, let me tell you about another little-known benefit of nitric oxide:

Meet Dr. Janet Zand
Dr. Janet Zand is a Doctor of Oriental Medicine, a Board Certified Acupuncturist and has practiced natural medicine for over 25 years . In! Magazine describes Dr. Zand as "Hollywood's Best Kept Health Secret," because of her "A"-list clientele of movie stars, rock stars and professional athletes. With over 25 years of experience in natural medicine, she was the co-founder of McZand Herbal and the formulator of ZAND Herbal Formulas. Dr. Zand is also the co-author of three books on natural health and healing, including Smart Medicine for a Healthier Child, Smart Medicine for Healthier Living and the Nitric Oxide Solution. She has been featured in Ellen, Allure, The Los Angeles Times, Life Time TV, and the BBC.

When We Need Nitric Oxide The Most

As you can see, nitric oxide is vitally important to our health. That's why it's so important to maintain healthy nitric oxide levels as we grow older.

Unfortunately as we grow older, our bodies have more trouble making nitric oxide. In fact, Japanese researchers have found that by the time we reach our 70s or 80s, we produce and use a staggering 75% less nitric oxide than we did when we were in our 20s. That means the years when you need nitric oxide the most are the years when you're most likely to be deficient.

With most deficiencies, you can simply take a supplement to bring your levels up. But it's not that easy with nitric oxide. Let me explain…

Why You Can Take L-Arginine and Other Nitric Oxide Boosters… and Still be Deficient

Most nitric oxide supplements use the amino acid l-arginine as the main ingredient. But it turns out that l-arginine isn't all it's cracked up to be.

What's wrong with l-arginine? All of the research and press indicated that it would help your nitric oxide levels soar. Well, it may sound good on paper. But all over the country, doctors and patients alike are reporting that they just aren't getting the results they hoped for. This is especially true in older patients. The older we get, the harder it is for our bodies to convert l-arginine into nitric oxide.

On top of that, l-arginine can cause side effects in some people. People taking l-arginine supplements have complained of sour stomach and digestive discomfort. But even with these limits, l-arginine isn't the only obstacle to boosting nitric oxide with supplements. The main obstacle was discovered in a lab at MIT.

MIT Researchers Accidentally Uncover Hidden Flaw in Nitric Oxide Supplements

MIT researchers discovered that the most important part of producing nitric oxide takes place before you even swallow!

That's right — the lion's share of nitric oxide is produced in your mouth, not in your stomach or intestines. It turns out that the saliva and beneficial bacteria in your mouth are necessary to create nitric oxide.

The longer nutrients are in your mouth, the more nitric oxide you produce. So if your food, drink, or supplements don't have time to interact with the saliva and bacteria in your mouth, you can't produce very much nitric oxide.

Well guess what? Virtually all nitric oxide supplements come in pill or powder form. Which means you swallow them and they go straight to your stomach. This bypasses the most important step in producing nitric oxide. That's why people taking those supplements have little hope of reversing their nitric oxide deficiency.

Fortunately, one of the world's leading experts on nitric oxide, Dr. Nathan Bryan, developed a brilliant solution to this problem. Dr. Bryan and his team developed a nitric oxide supplement unlike any other available on the market.

How to Flood Your Body With Nitric Oxide…
to MIT Breakthrough Research

Thanks to the MIT breakthrough research I mentioned above, Dr. Bryan's team knew their supplement had to interact the saliva and bacteria in your mouth. They knew it was the only way to produce enough nitric oxide to reverse the deficiency that happens as we grow older. That's why they created CircO2®.

CircO2® is not a pill and it's not a powder.

CircO2® is a lozenge.

As a lozenge, CircO2® interacts with the saliva and bacteria in your mouth. You simply pop the lozenge in your mouth (it tastes good, I promise) and move it around your mouth. You can chew it if you like. Your saliva and the beneficial bacteria in your mouth convert the nutrients in the lozenge into nitric oxide. So with every swallow, you get an immediate boost of nitric oxide.

And Dr. Bryan's team went further to create an innovative way to prove CircO2® actually improves blood flow in your body, and does it fast.

These are thermal, or heat sensitive images of a person's back. The image on the right shows a higher skin temperature just 29 minutes after taking one CircO2® lozenge. The more vivid red color shows the improved flow of blood circulating in the body. Just imagine how you could benefit from improved blood flow like this due to the immediate boost of nitric oxide.

Boost Nitric Oxide and Blood Flow in Your Brain!

The main ingredient in CircO2® is a special blend of extracts from herbs and beets. Why beets? Because studies have proven that beets are one of the best natural ways to boost nitric oxide levels.

In fact, Wake Forest University scientists not only proved beets boosted nitric oxide, they actually saw the effects in the brains of people who drank beet juice.

How did that happen? First, scientists had people drink beet juice in the morning. Then they took blood samples and MRIs of their brains. They compared the samples and MRIs to the ones they took when the same people didn't drink beet juice.

When they compared the results, the blood samples proved that beet juice increased nitric oxide levels. And the MRIs showed that, just hours after drinking the beet juice, the brain was flooded with a steady flow of blood.

And what was really exciting was where the blood flow increased. It increased most in the areas that are associated with poor cognition as we get older. So those areas received more oxygen and more nutrients than they would with lower nitric oxide levels.

More oxygen and nutrients help keep brain cells healthy, active and functioning properly. And more healthy brain cells help you think clearer and respond faster, no matter what your age.

And CircO2® gives us another ingredient to convert into nitric oxide and boost our levels even further.

The Amino Acid That Boosts Nitric Oxide… Without the Nasty Side Effects

CircO2® uses l-citrulline instead of l-arginine. As I explained earlier, we lose the ability to easily convert l-arginine into nitric oxide as we grow older. But that doesn't happen with l-citrulline. Older people convert l-citrulline into nitric oxide more easily. And l-citrulline doesn't cause nausea, diarrhea or digestive problems like l-arginine.

CircO2® also contains hawthorn. You may know hawthorn as a time-tested natural way to boost you circulation.

Since CircO2® contains beets, l-citrulline and hawthorn, taking it will give you a surge of nitric oxide. Even people over 40 whose bodies struggle to produce nitric oxide as they get older.

It's clear that CircO2® is packed with ingredients that easily become nitric oxide, regardless of your age. But what good will all that nitric oxide do if your body isn't prepared to use it?

How to Get The Most Out of the Fresh Surge of Nitric Oxide

CircO2® goes beyond boosting nitric oxide. It also contains ingredients that help your body make the most of the nitric oxide surge.

  • Vitamin B12: enhances the ability of cells to process nitric oxide and increase energy. It also keeps your brain and nerves healthy and working properly.

  • Vitamin C: Vitamin C helps make nitric oxide available to cells throughout your body. It helps grow and repair tissues. And it enhances calcium absorption for stronger bones.

  • Magnesium: Magnesium helps maintain a healthy heart rhythm. It prevents calcium from building up in your arteries. And it relaxes the muscles in your arteries so blood flows smoothly.

It is remarkable that CircO2® also contains these extra ingredients. These ingredients help your body to better use the extra nitric oxide CircO2® helps you produce. And there's one more thing about CircO2®. CircO2® is the only nitric oxide supplement on the market that lets you test for yourself whether it works or not!

Supplement Facts

Serving Size 1 lozenge
Servings Per Container: 30
 Amount Per Serving  %         Daily Value
 Vitamin C (as magnesium ascorbate and ascorbic acid) 100 mg        167%
 Vitamin B12(as methylcobalamin and cyanocobalamin) 1000 mcg    16,667%
 Proprietary Nitric Oxide Blend
      Beet Root Powder (root), Hawthorn Berry Extract (berry), L-Citrulline, Sodium Nitrite
420 mg           *
  *Daily Value not established.
   Other ingredients: mannitol, modified cellulose, xylitol, natural flavors, magnesium vegetable stearate, stevia, silica, natural carmine color.

How to Tell if You're Low In Nitric Oxide
— With a Simple Do-It-Yourself Test

When you order CircO2® lozenges you don't just receive the breakthrough nitric oxide lozenges — you also receive do-it-yourself test strips that measure your nitric oxide level. That means you can know immediately whether you even need to take a nitric oxide supplement or not. There's no guesswork involved.

They're simple to use. All you have to do is place a drop of your saliva on the test strip and then compare the color to the chart on the package. How easy is that?

If the strip turns dark pink, your nitric oxide levels are fine. If that's the case, simply box up the CircO2® and send it back for a quick and easy refund.

If the test area is a pale pink, then you know you need more nitric oxide.

If you're not taking a nitric oxide supplement, you'll know you're deficient. If you are already taking a nitric oxide supplement, you'll know it's not working for you.

I used the strips myself to test my own nitric oxide level. Boy, was I surprised with what I found.

"I Was Shocked to Discover
I Was Deficient in Nitric Oxide In Spite of a Healthy Diet and Supplements"

When my package of test strips and CircO2® arrived, I'll admit I was smug. I had been taking an l-arginine nitric oxide supplement, so I was sure I would test well. I followed the directions, and when I matched my strip to the color blocks on the package — I was shocked to discover I was deficient!

After my initial shock, I realized why I had been so smug. Like a lot of people I exercise, eat well, and take high-quality supplements. I thought that was enough. Boy, was I wrong!

When I saw my pale pink test strip, I decided right there and then to give CircO2® lozenges a try. And I'm glad I did.

The test strips after I took CircO2® proved the lozenges really had boosted my nitric oxide levels. But I didn't need the test strips to tell me the lozenges were working.

On the very first day I took CircO2®, I felt more energy. By the fourth day, I still felt energized. I realized I also felt more alert. A few days later, I tackled a bunch of tasks around my house and organized my office.

And you know what? Even after doing the work that I had been dreading and putting off for so long… I still felt energized. I still felt alert. And I still felt motivated to do even more.

I love that feeling — and I know you will too!

That's why I called up my friends at CircO2® and arranged a great deal for my readers.

Order Now & Save $36.95 Plus Get Free Shipping

"Down to the Last Lozenge Guarantee"

I'm so sure that you're going to be thrilled with CircO2® that it comes with our famous "down to the last lozenge" guarantee.

If you aren't happy with CircO2®… if you don't feel like it's working… if anything about the product doesn't thrill you… just send it back within 90 days of your purchase for a refund. It doesn't matter if you've taken one day or one month's supply. Just send back whatever you have left within 90 days and you'll get your money back. All of your money. Every penny. Including shipping and handling! You only pay return shipping.

And because CircO2® comes with test strips, you have a quick and easy way to tell if CircO2® is right for you. One strip will tell you if it's working or not. You don't even have to think about it.


Ways We Guarantee the High Quality of
Advanced Bionutritionals Supplements

I'm sure you've heard of vitamins, herbs, and other nutritional products that flunked lab tests. Here at Advanced Bionutritionals, we strive to make sure that NEVER happens.

In Fact, our manufacturing process guarantees purity, potency, and quality in 9 different ways:

We use suppliers and growers that we've known for years.
We use ingredients that are shown to be effective in scientific studies.
We use no artificial colors, artificial binders, artificial fillers, or artificial preservatives, and non-GMO sources whenever available.
Every supplier is qualified by testing multiple lots of material. The material is assayed for purity and screened for pathogens like mold, yeast, staph, and salmonella.
The batches of our ingredients are tested using FTIR spectrometers and compared to a purity index.
Our products are manufactured in a facility that is GMP (Good Manufacturing Practices) certified.
Batches of our product undergo rigorous disintegration tests in conformance with USP guidelines to ensure proper breakdown in the stomach and absorption in the intestines.
Our manufacturing process has multiple checks in place, and our batches are signed off by a quality control officer to ensure accuracy, purity, and potency.
Our bottles are safety sealed for lasting freshness and potency. And each bottle is marked with a manufactured date and/or an expiration date.

Measure the Difference… Feel the Difference …Or You Pay Nothing

I want you to try CircO2®. Measure your nitric oxide levels before and after you start taking it. Pay attention to how you feel. If you aren't absolutely thrilled — if you aren't convinced it's doing everything you want it to and more — simply return the unused portion within 90 days for a full refund of every penny you paid.

To keep your nitric oxide levels up, I suggest you take advantage of our 3-month discount. You'll receive enough CircO2® for 90 days plus save $15.00 off the single bottle price and get free shipping too!

Better yet, order a 6-month supply. You'll save $50.70 off the single-bottle price and get the free shipping too.


It's easy to order CircO2®. Simply order below or call us toll-free at 1-800-791-3395 (24 hours a day, 7 days a week). Once we receive your order, we'll rush it right out to you.

Listen, if you've been feeling run down… if you want a sharper mind and faster memory… there's no sense in waiting.

Order right now and reclaim your health and reenergize your life. You can always get a refund if you aren't thrilled.

To a better life through better health,

Dr. Janet Zand, M.D.

Janet Zand, OMD, L.Ac.

P.S. If you're over 40, please try CircO2® and feel for yourself the difference nitric oxide can make! With the "Down to the Last Lozenge" guarantee, you have nothing to lose! You even get test strips so you can see for yourself if your nitric oxide levels are increasing. Order below and get back the energy, clarity and health you had when you were younger. You'll be glad you did!


"Feeling better than I have in 10 years."

- Ken H., CircO2 Customer



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CircO2 Reviews




  • Kim ID, Ha BJ. Arch Pharm Res. 2010 Jun;33(6):959-66.

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