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Diane Fogarty

Bottle of Nrf2

Protandim® Nrf2 Synergizer* Support


  • Yes, if you purchase the Vitality Stack (packets/bottles), Activated Essentials, or the Ultimate Stack, you will receive free shipping. If you add additional products to your order when ordering these stacks, your entire order will ship for free.

  • Yes, the Vitality Stack Packets are BPA free.

  • Yes.

  • Protandim Nrf2 and Nrf1 Synergizers work together to reduce oxidative stress and support mitochondria biogenesis and function. With the addition of NAD Synergizer, we can now target other biochemical pathways known to support healthy aging and increased health span.

  • Researchers and scientists agree that aging is the natural result of overall cellular deterioration. One major way this occurs is through exposure to free radicals, other oxidants, and toxicological insults. It is impossible to avoid these exposures because the food you eat, the air you breathe, our modern lifestyles, stress, and even exercise, but we can do certain things to maintain our health as we age. The human body naturally fights these insults by producing its own antioxidant and detoxification enzymes through Nrf2-dependent mechanisms. However, as we grow older, Nrf2 works less efficiently. That’s where Protandim® Nrf2 Synergizer TM plays a critical role. It supports these Nrf2-dependent mechanisms to boost the body’s production of antioxidant and detoxification enzymes. Another natural phenomenon relating to the aging process is our mitochondria (the cell’s powerplant) begins working less efficiently. Less efficient mitochondria produce less energy and produce excess free radicals and other oxidants. Supporting overall mitochondrial function is important to promote overall health as we age. Protandim NRF1 was designed to both increase mitochondrial number and provide ingredients shown to support mitochondrial health. Lastly, another major significant effect of the aging process is a decline of cellular NAD levels and reduction of sirtuin activity. Sirtuin activity has been shown to play a major role in supporting overall health. Protandim® NAD Synergizer TM was designed to support NAD levels and sirtuin activity. Thus, taking the entire Protandim family of products will help support all of these significant aspects of the aging process.*

  • Yes!

  • Protandim Nrf2 Synergizer’s results stem from its ability to activate the transcription factor known as Nrf2. Nrf2 is a protein messenger contained in every cell of the body that sends information to the cell’s DNA. Protandim Nrf2 Synergizer contains five ingredients that are known as Nrf2 activators.

    When Nrf2 is activated, it enters the nucleus and turns on several hundred genes, known collectively as “survival genes.” These genes enable cells to survive in the face of several different kinds of stress, especially oxidative stress, which occurs when free radicals and other oxidants overwhelm the body’s natural antioxidant enzymes. As a Nrf2 activator, Protandim Nrf2 Synergizer helps keep the body safe from free radicals and oxidants by activating these survival genes.

  • Instead of providing the body with additional dietary antioxidants, Protandim Nrf2 Synergizer supports your body from within by turning on its own antioxidant defense system. By upregulating the production of antioxidant enzymes and other protective proteins, Protandim Nrf2 Synergizer helps to reduce free radical damage and prepare cells for exposure to future stressors. Additionally, each antioxidant enzyme can react with and deactivate millions of free radicals every second. This makes them one million times more effective than dietary antioxidants, which can only scavenge free radicals on a “one-to-one” basis. This is why Protandim Nrf2 Synergizer is different than any other dietary supplement on the market today.

  • No, they are not certified organic; however, at LifeVantage, we perform pesticide, herbicide, and heavy metal testing on every lot of raw material to assure we have only safe, high quality products.


  • • Withania somnifera (Ashwagandha) root extract (sourced from India)
    • Camellia sinensis (Green Tea) leaf extract (sourced from China)
    • Silybum marianum (Milk Thistle) seed extract (sourced from China)
    • Bacopa monnieri (Bacopa) whole plant extract (sourced from India)
    • Curcuma longa (Turmeric) root extract (sourced from India)

  • Yes, the Quality Control measures implemented by LifeVantage go beyond industry standard. LifeVantage rigorously tests every lot of active raw material for identity, potency, microbial contamination, pesticides, and heavy metals. Unlike most dietary supplement companies, we also physically audit all of our active raw material suppliers. We perform exhaustive testing to verify that all materials meet or exceed quality specifications.


  • No, there are no dyes or food colorings in Protandim Nrf2 Synergizer. One of the active ingredients in Protandim Nrf2 Synergizer, Curcuma longa (Turmeric) is intensely yellow, adding to the yellow coloring of the tablet.

  • No, the individual ingredients in Protandim Nrf2 Synergizer aren’t as effective in activating the Nrf2 pathway as LifeVantage’s botanical blend. Previous studies of Protandim Nrf2 Synergizer have shown a very clear and potent synergy whereby the 5-ingredient blend is significantly more effective than any of the individual ingredients in 1) inducing Nrf2; 2) triggering the production of internal antioxidant enzymes and; 3) stimulating the expression of a variety of
    cellular survival genes.

  • DiCalcium Phosphate and Calcium Carbonate (listed as “Calcium” in the Supplement Panel), Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Modified Cellulose, Stearic Acid, Magnesium Stearate, Maltodextrin, Medium Chain Triglycerides. The “Other Ingredients” in Protandim Nrf2 Synergizer serve as binding and processing aids during the production of the tablet.


  • Protandim Nrf2 Synergizer contains 1.8 mg of caffeine per tablet. (By comparison, Starbucks coffee may contain up to 150 mg and “caffeine free” coffee may contain between 4-7 mg.)

  • Yes, the raw ingredients are pressed into tablet form. Our tablets are pressed without any extraneous heat. The only heat that results from the process is from natural friction. There is no raw material degradation from the process. This is considered “cold” pressed or “soft” pressed.


  • We do not expect there to be any side effects for the typical Protandim Nrf2 Synergizer consumer. However, some individuals may have natural allergic responses or sensitivities to one or more of the ingredients, just as some people are allergic to pollen or penicillin. These allergic responses to Protandim Nrf2 Synergizer generally appear as gastrointestinal disturbances (i.e., stomach ache, diarrhea, vomiting) or sometimes as a headache or rash on the hands or feet. The symptoms typically disappear if Protandim Nrf2 Synergizer use is discontinued. If you are experiencing any adverse reaction, discontinue use of the product and call Distributor Support at (866) 460-7241.



  • Many people mistakenly believe their antioxidant needs are fulfilled by eating blueberries, drinking expensive “miracle juices” and applying antioxidant facial creams. What they don’t realize is that their daily antioxidant needs cannot be fulfilled by consuming any amount of blueberries, dark chocolate or red wine. Effective antioxidant protection absolutely requires adequate production of the body’s own antioxidant enzymes. Protandim Nrf2 Synergizer contains a unique, patented blend of ingredients that have been proven to stimulate the production of antioxidant enzymes and protect against cellular stress.

  • No, there is no known mechanism whereby Protandim Nrf2 Synergizer loses effectiveness over time. The formula has not been changed, and bioactivity is monitored to maintain consistent potency with regard to the activation of the Nrf2 transcription factor–the mechanism by which Protandim works.


  • The shelf life for Protandim Nrf2 Synergizer is three years from the date of manufacture.

  • It’s best to take Protandim Nrf2 Synergizer with food.  Some of the active ingredients in Protandim Nrf2 Synergizer are fat soluble. Although it is not absolutely necessary, taking it with a meal containing some fat allows the ingredients to be absorbed more efficiently.

  • Yes! Protandim Nrf2 Synergizer is not a controlled substance, nor does it contain any banned or controlled substances. The BSCG symbol on the Protandim Nrf2 Synergizer label assures consumers that every lot of Protandim Nrf2 Synergizer has been analyzed and certified by the Banned Substances Control Group (BSCG) to be free of all substances banned by the World Anti-Doping Agency.

  • Protandim Nrf2 Synergizer is the only supplement proven in a peer-reviewed, human clinical study to reduce cellular stress in humans by an average of 40 percent in 30 days. Protandim Nrf2 Synergizer is patent protected and is the subject of 20 peer-reviewed clinical studies. Protandim Nrf2 Synergizer works to support the body’s own protective measures by turning on its internal antioxidant defense system, regulated by the protein Nrf2. When activated, Nrf2 triggers cells to produce naturally occurring antioxidant enzymes as well as housekeeping “cleanup” proteins which work together to deliver balanced protection against cellular stress.

  • Researchers and scientists agree that aging is the result of cellular deterioration caused by free radicals. It is impossible to avoid free radicals because the food you eat and the air you breathe, as well as stress or even vigorous exercise, can stimulate cells to produce destructive free radicals in staggering numbers. The human body fights free radicals by producing its own antioxidant enzymes, but as we grow older our bodies produce more free radicals and fewer of these antioxidant enzymes to fight the battle of aging. That’s where Protandim Nrf2 Synergizer plays a critical role by boosting the body’s production of antioxidant enzymes at the cellular level with enough neutralizing
    capacity to reduce age-related increase in free radical damage.

  • Yes! The Axio products are designed to improve both physical and mental energy levels, while Protandim is designed to reduce cellular stress by activating the body’s protective Nrf2-pathway. Since the AXIO products contain several ingredients with known Nrf2-activating effects (Green tea extract, New Zealand pine park extract, and Quercetin), it is recommended to consume Protandim and AXIO at least one hour apart from each other, and ideally up to two hours apart, for optimal absorption and efficacy of each product.

    For example, many people prefer to take their Protandim with breakfast or another meal to optimize absorption, while the AXIO is typically used between meals to maintain physical energy, mental focus, and overall well-being. Even though the AXIO contains several ingredients with Nrf2-activating effects, these ingredients are quite different from the ingredients in Protandim (even the green tea extracts are very different between products, with different methods of extraction and different bioactive polyphenol profiles). The Protandim formula has been optimized to provide Nrf2-synergy between each of it’s five individual ingredients, while the AXIO has been optimized to provide a multi-dimensional energy boost for both body and mind.


Protandim® Nrf2 Synergizer™* Downloads

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