Piracetam Nootropic – Benefits and Effects of Cognitive Enhancement

Piracetam is the first ever-synthetic smart drug developed, and through this word, nootropic came in creation.

It is one of the most researched nootropics, with thousands and hundreds of research and trials on a clinical basis.

Piracetam is a safe and popular nootropic that is reliable for brain-boosting. It has been used for more than 50 years, and still, people are using it and discovering its potential.

  • KNOWN AS: Nootropil, Lucetam, Breinox, Dinagen
  • TYPE: Racetam
  • GOOD FOR memory, learning
  • STACKS WITH: Alpha GPC, Oxiracetam, CDP Choline, Phenylpiracetam, Sulbutiamine, Centrophenoxine
  • DOSAGE: 4800mg
  • HALF-LIFE: 4 to 5 hours

In 1964, Romanian psychologist, Dr. Cornelius Giurgea, who invented piracetam, he synthesized a compound which could safely enhance memory and ability to learn.

He invented the word, nootropic. In Greek, Noos means mind and troopien mean to bend and turn.

Piracetam Nootropic Drug Review

Piracetam is a recurring derivative of inhibitory neurotransmitter GABA.

The body does not produce piracetam, nor does it occur in food or in any natural food source.

The legal availability of piracetam is not the same in every country or nation, but it varies from nation to nation. It cannot be legally available in the market in the USA for dietary purposes; it can be sold for research purposes and can be legally purchased without a prescription.

In Canada, it cannot be legally purchased but can be legally bought for individual use. In the UK and Australia, piracetam is present for buying, but for buying it, you should have a proper prescription.

Maybe a small amount can legally be purchased for personal use in other nations.

Piracetam Benefits and Effects

There are numerous benefits and effectiveness of piracetam.

That is why many people who want to enhance their memory and learning abilities use it. As it is the most popular and widely used nootropic.


Piracetam was made to enhance cognitive abilities, and it is widely used for this purpose. Clinical trials and subjective evidence shows that piracetam is an effective brain booster, especially in the areas of concentration, memory, and motor skill. [1]

It shows cognitive abilities in children, yet it is very effective in older people as well, who experience cognitive decline as they age.

Cognitive enhancement effect of piracetam in patients

By improving blood flow within the brain and boosting production and function for brain chemicals, piracetam increases the creation and maintenance of the new connections between neurons, which is important for learning.

People who have been using piracetam reports that piracetam helps to improve focus, increase in energy, and enhances verbal and creative fluency, especially when taken with the combination of choline. Studies have shown that piracetam increases verbal learning in both healthy children and children who suffer from dyslexia.

It is popular among children who need to focus on their studies. Once introduced in the diet, you will see a very visible change in vocabulary and improvement in expressiveness.

Not only it helps to increase and develop creativity in fact, but it also helps to bring up different ideas and turn them into reality.


It has been proved a powerful memory enhancer, especially when taken with the combination of choline. The main reason for enhancing the memory in both animals and humans is that it makes the blood flow to and within the brain, which increases the cellular membrane fluidity.

However, piracetam has shown great improvement in memory part in all age groups, including children who have received general aesthetic and even in healthy adults. [2]

Due to some factors such as lack of sleep or increased level of stress, in which people cannot perform in their daily routine properly, therefore they turn towards nootropics.

A study on zebra fish who was given piracetam showed significant results when it comes to mazes.


Studies show that piracetam reduces the symptoms of depression and its related conditions, such as stress and anxiety.


It is also valuable for therapy for drug-resistant depression in patients with psychotic conditions, as It provides a rapid and significant improvement.

Students who are unable to perform under pressure, experience different emotions such as fear of failure, anxiety and mood swings, and other conditions. 

These problems can extend to sweating, insomnia, and depression.

According to the studies, It helps to solve these issues. If you suffer from problems like mood swings and unable to focus on studies, this piracetam helps to improve all these, as it is a strong mood lifter.

On the other hand, people who suffer from a terrible disease like depression, taking the recommended dosage of piracetam, will help to resist the conditions of depression and also reduces the signs of anxiety and stress, which are the predecessors of depression.


It has shown to have powerful neuroprotective properties, which effects are protecting the brain against age-related decline. It has successfully been used as a neuroprotectant in stroke patients and treating cognitive disorders caused by trauma.

Even if you are mentally healthy and not suffering from any illness, still neurons in our brain die. This process is called apoptosis. Our neurons die because of aging in a natural phenomenon. However, it is natural to use the full potential of the brain for as long as possible.

In students, it is nothing to worry about as the neurons are up and running.

Therefore, for children, it is safe. On the other hand, in old people, It works as a shield that protects the neurons from damaging as they age. This protects the brain from damaging and protects it from diseases such as dementia.

Piracetam is also used during open-heart surgeries and prescribed to those who have experienced a stroke in their lives. It has got powerful neuroprotective properties, as this nootropic is very helpful when preserving brain functions in patients who have suffered from nerve damage or undergoes surgery.


Piracetam has anticonvulsant properties, which makes it a valuable addition to the therapy in the treatment of epilepsy and other disorders.


It has an interesting effect on senses as it increases acetylcholine activity. If you want to see brighter colors, to show excitement or to enjoy a sunny day, it is for sure to use this nootropic. This will also contribute to boosting the mood as well.


Ongoing research on piracetam indicates that it is also helpful and effective in treating other disorders such as schizophrenia, neuro inflammation, alcoholism, and another age-related cognitive decline.

Piracetam in the treatment of schizophrenia

An innovative study in 2017 looked at the positive potential in piracetam is used as heroin for adults.

The authors said drug trafficking in Asia and Europe are adding piracetam to heroin as it provides intense experience and decreases hangover, effects that are attributable to piracetam’s neuroprotective effects.

It is also in progress of study as a treatment for binge eating disorder or BED, it is a stress-related disorder which causes unusual eating habit which comes in episodes.

BED is known to compromise acetylcholine levels, which leads to anxiety and cognitive disorder.

In 2018, a study showed in an animal that using piracetam regulates acetylcholine levels, reduces alleviated BED related cognitive deficit, and decreases BED and associated body weight.

How Piracetam Nootropic Works?

Although this nootropic has yet to be understood, this nootropic still is not yet known how it gives benefits.

Piracetam Supplement - Science-based Review on Benefits

It is widely believed that piracetam works by increasing blood flow and acting various crucial neurotransmitters for our brain.


One of the cardinal means by which piracetam improves and enhances memory, verbal fluency, focus, and other cognitive abilities by increasing blood flow to and within the brain. Cognition depends upon proper blood circulation, which supplies oxygen to the brain, which supplies important nutrients to the brain cells, which is needed to function properly.

The increase in blood flow increases the number of blood cells, which does not stick to the wall and supplies nutrients to the brain. Continuous intake of this nootropic in the recommended dosage, the metabolism of the brain becomes faster and productive.

Because of this, a person can understand and respond faster to visual and verbal stimuli. That is why piracetam intake results in cognitive functions. Due to its positive effects on blood vessels, It is a positive addition to people who suffer from heart problems.

As the blood flow is smooth and red blood cells do not adhere to the walls, the nutrients can pass easily to the brain and can supply blood, which improves cognitive functions.

Research has shown that piracetam increases the permeability of neurons, which makes nutrients enter in brain and waste to be eliminated.


Neurotransmitters are like messengers in the body which transfers the message from one point to another. Piracetam increases the number of neurotransmitters in the brain.

Therefore, the person who adds this in their diet might feel:

  • Enhanced learning
  • Improvement of focus
  • Increased energy level
  • Better mood
  • Higher memory capacity

Acetylcholine is one of the most important neurotransmitters in the body. According to a study, It reacts with acetylcholine in the brain and makes it more productive. [3]

While these actions are happening, the brain quickly reduces the level of choline. Therefore, it is recommended to use choline supplements with piracetam to avoid the reduction of choline in the brain.

Acetylcholine is responsible for vital functions in the brain, especially for a student’s brain, as it helps to concentrate and learn more effectively, which can help to use cognitive abilities much faster.

When it is combined with piracetam, acetylcholine works faster, and this makes you a quick learner.

It is also modulated the brain receptors of glutamate, which is a neurotransmitter which is responsible for 90% of synaptic connections. Glutamate is responsible for synaptic plasticity, which is the ability of synapses to become strong or weak over time.

Synaptic plasticity is essential for cognitive functions such as memory and learning, and by an increase in glutamate receptors, It enhances memory and learning ability.

Piracetam Dosage

There is no precise dosage recommended per day; however, split the standard dosage, which is recommended for an adult person, is 4800 mg per day, which can sometimes be, into three doses.

How to take Piracetam drug

A research study has shown that the average dose of 4800mg of piracetam is most effective for adult users.

Another study has shown, taking 1200 mg of piracetam per day by an adult, taken three times per day, has positive effects for cognition.

It is rapidly absorbed in the body, reaching blood concentration within 60 to 90 minutes after dosing. [4]

Its half-life is approximately 5 hours. Positive effects can be measured immediately, but for full effects, it takes around 2 weeks.

Nootropic users recommend using a higher dose for better visibility of the result, but it is better to start from a low dose first and then increase the dosage slowly.

This way, you won’t be tolerant of piracetam and can enjoy its effects for a longer time.

Piracetam Stack

It is a well-research nootropic in the market. Piracetam effects have been studied and proven by many institutes and researchers.

Many experts suggest taking piracetam without any combination as it gives a lot of benefits to the users.

However, the use of piracetam decreases the choline level in the body, so it is better to add or use choline in your daily diet plan.

1) Piracetam and Alpha GPC

For instance, if you use 4800 mg of piracetam, then you must consume 300mg of Alpha GPC in it.

Piracetam Stacking with Alpha GPC, Choline and Aniracetam

Even though It can be taken on its own, but its effects are more effective when used in combination with other compounds.

Choline is an essential compound that is to be taken when using piracetam, as acetylcholine level depletes when using piracetam.

When on piracetam, our brain needs more choline intake. Therefore, without choline supplementation, it is impossible to complete the levels of choline in the brain, which leads to headaches and foggy feelings.

2) Piracetam and Choline

Stacking piracetam with choline not only lessens the negative effects but also allows piracetam to work even more effectively than without choline.

There are many sources of choline, but it is better to use Alpha GPC or Citicoline. When using these good qualities of choline, a good starting point is 1 part of choline with eight parts of piracetam. [5]

It is commonly stacked with other racetams. When the combination is with another nootropic, the results are synergistic.

Aniracetam is the most common racetam, which is combined with piracetam, as Aniracetam is an excellent nootropic for memory, mood, and creativity.

3) Piracetam and Aniracetam

The common ratio of piracetam to Aniracetam is 4:1.

Nevertheless, when stacking, the potency of nootropic increases; therefore, it is better to use the dosage of nootropics with accordingly. Such as:

Taking one or two times per day, the dosage of these nootropics becomes:

  • Piracetam: 2400 mg
  • Alpha GPC: 300mg
  • Aniracetam: 750mg


It is known for its safe use, as there are no major side effects from its use. A little minor side effect happens, which are controllable such as:

  • Headaches
  • Insomnia
  • Anxiety

Other than those side effects, some more mild common side effects have been seen which includes:

  • Weight gain
  • Diarrhea
  • Drowsiness
  • Nervousness
  • Muscle spasm
  • Depression
  • Hyperactivity
  • Rash

Headaches are widely reported as a side effect of piracetam, which happens most probably because of stacking with a choline supplement.

8 grams of piracetam has been given to patients of Alzheimer’s disease, clinical studies have shown no side effects occur to those patients.


Piracetam is not commonly found in stores or pharmacies.

However, it can buy from online sellers. There are a couple of websites that sell piracetam, but you have to make sure of the originality of the product before buying.

You can buy all nootropic supplements at Amazon store including Piracetam!


Piracetam is an old synthetic nootropic that belongs to the racetam family.

A lot of studies have been done on this nootropic and are very effective and enhances brain development, memory, and learning abilities.

It is safe to use and has no side effects other than a few minor ones, which can be tolerated. It is effective for both heart and mind.