What are the histologic characteristics of clear cell carcinoma in renal cell carcinoma (RCC)?

Updated: Feb 19, 2021
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Clear cell carcinoma is characterized by unusually clear cells with a cytoplasm rich in lipids and glycogen, and it is most likely to show 3p deletion. Chromophilic tumors tend to be bilateral and multifocal and may have trisomy 7 and/or trisomy 17. Chromophobic carcinoma is characterized by large polygonal cells with pale reticular cytoplasm characterize, and it does not exhibit 3p deletion.

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