DNA cross-link repair 1C

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA384 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
adaptive immune response [GO:0002250],
double-strand break repair via nonhomologous end joining [GO:0006303],
response to ionizing radiation [GO:0010212],
B cell differentiation [GO:0030183],
protection from non-homologous end joining at telomere [GO:0031848],
V(D)J recombination [GO:0033151],
interstrand cross-link repair [GO:0036297],
nucleic acid phosphodiester bond hydrolysis [GO:0090305],
telomere maintenance [GO:0000723],
immune system process [GO:0002376],
DNA repair [GO:0006281],
double-strand break repair [GO:0006302],
DNA recombination [GO:0006310],
cellular response to DNA damage stimulus [GO:0006974],
chromosome organization [GO:0051276],

Molecular Function:
single-stranded DNA endodeoxyribonuclease activity [GO:0000014],
damaged DNA binding [GO:0003684],
endonuclease activity [GO:0004519],
protein binding [GO:0005515],
5'-3' exonuclease activity [GO:0008409],
5'-3' exodeoxyribonuclease activity [GO:0035312],
nuclease activity [GO:0004518],
exonuclease activity [GO:0004527],
hydrolase activity [GO:0016787],

Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
nucleoplasm [GO:0005654],
Golgi apparatus [GO:0005794],
nonhomologous end joining complex [GO:0070419],
nucleus [GO:0005634],