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Interleukin 7 (IL-7) is a pleiotropic cytokine of 177 amino acids (molecular weight 17.4 kDa) with central roles in modulating T- and B-cell development and T-cell homeostasis. The primary sources of IL-7 are bone marrow-derived stromal and epithelial cells. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, and hepatocytes. IL-7 promotes hematologic malignancies and is associated with viral infection. Circulating levels of IL-7 increase in response to T-cell depletion, suggesting a role in T-cell regeneration