Pathways of apoptosis in muscle 1


Other Talks in the Category: Diseases, Disorders & Treatments

Apoptosis in skeletal muscle is more precisely described as nuclear apoptosis.
Why this distinction for nuclear apoptosis? Muscle fibers are multinucleated and consisted both post-mitotic myonuclei, and Dorman's satellite cells, so they're capable of proliferation. Unlike single-cell systems, which die if the nucleus is eliminated by apoptosis, the elimination of a single nucleus may make muscle fiber a little bit smaller, but it will not result in the death of the multinucleated muscle fiber. Many nuclei must die and be eliminated before the entire muscle cell dies.