@article{055d62b98ba0405aa2e2ed325f69fd8b, title = "El parto pret{\'e}rmino: Herramientas predictivas y preventivas en la pr{\'a}ctica clinica", abstract = "Despite advances in both neonatal care and our understanding of the pathophysiology of the condition as a whole, preterm birth is a phenomenon that continues to have significant impact globally. It remains the leading cause of perinatal morbidity and mortality worldwide, and the prevalence is increasing. Not only does it carry significant social cost, preterm birth places huge economic burden on the healthcare system. It is increasingly recognised that preterm birth is a multifactorial syndrome, rather than a single condition and we have seen a number of exciting advances in predictive and preventative tools for clinical practice. The ability of quantitative fetal fibronectin to predict spontaneous preterm birth in both high and low risk women has been one of these recent promising developments. Exploration continues into the potential for quantitative fetal fibronectin to be used in synergy with transvaginal ultrasound measurement of cervical length to improve predictive accuracy. Developments focus on enabling clinicians to predict risk at the point of care. Research continues to explore cervical cerclage, progesterone and the Arabin pessary as prophylactic interventions for women at risk of preterm birth, with increasing evidence for their potential role. Latest exploration of reactive management for imminent preterm birth is altering our clinical approach and is likely to improve outcomes. This review article will discuss some of the recent developments we have seen in this exciting area.", keywords = "Cervical length, Prediction, Preterm birth, Prevention, Quantitative fetal fibronectin", author = "Shennan, {Andrew H.} and Alexandra Ridout and Georgia Ross", year = "2017", month = mar, day = "1", doi = "10.21840/siic/149973", language = "Portuguese", volume = "22", pages = "331--337", journal = "Salud(i)Ciencia", issn = "1667-8982", publisher = "Sociedad Iberoamericana de Informacion Cientifica", number = "4", } @article{3a02fac7b9d64f35b27f8cd16c701d87, title = "Transtorno bipolar: Uma revis{\~a}o dos aspectos conceituais e cl{\'i}nicos", abstract = "This review aims to introduce historical, epidemiological and etiological aspects of bipolar disorder, also to present the characterization and course of the disease, as well as some issues related to the diagnosis, treatment and prognosis. Bipolar disorder (BD) is characterized by severe mood disturbances, involving periods of elevated mood and depression intercalated with periods of remission. The disorder is distinguished into two main types: Type I, in which episodes of mania occur; and Type II, in which mood elevation is milder and briefer, characterizing episodes of hypomania. The concept of bipolar spectrum extends the classification of BD, including clinical and genetic patterns. BD is a common disease that strikes about 30 million people worldwide, affecting men and women differently. The causes of BD include the interaction of genetic and environmental factors, distinguishing it as a complex and multidimensional disorder. The diagnosis according to DSM-5 involves the identification of mania or hypomania symptoms and the longitudinal evaluation of the disease course. Depression is usually the most common and persistent condition among bipolar patients. Although there are no specific symptoms that distinguish unipolar depression from bipolar depression, typical clinical features of each manifestation were found (e.g., symptom profile, family history, and disease course). Early diagnosis and the treatment of acute mood episodes significantly improve the prognosis. The first choice treatment involves mood stabilizers, anticonvulsants and atypical antipsychotics. The combination of medication with psychosocial interventions has been proved effective. However, the use of antidepressant monotherapy is not recommended.", keywords = "Bipolar Disorder, Depression, Bipolar, Manic Disorder, Manic-Depressive Psychosis", author = "Bosaipo, {Nayanne Beckmann} and Borges, {Vin{\'i}cius Ferreira} and Juruena, {Mario Francisco}", year = "2017", month = jan, day = "1", doi = "10.11606/issn.2176-7262.v50isupl1", language = "Portuguese", volume = "50", pages = "72--84", journal = "Medicina (Brazil)", issn = "0076-6046", publisher = "Faculdade de Medicina da Universidade de Sao Paulo", }