
The Carcinogenic Potency Project

N-Methylolacrylamide (CAS 924-42-5)
SMILES, InChI and Structure are below.
Rats and Mice: Cancer Test Summary
Male Female Male Female Rat Mouse
no positive no positive hag liv lun hag liv lun ova no positive 26.6m

Key to the Table Above

Target Site Codes:   hag = harderian gland. liv = liver. lun = lung. ova = ovary. Target sites are listed if any author of published experimental results concluded that tumors were induced in that organ by the test agent. If there is more than one positive experiment in a sex-species, target sites listed may be from more than one experiment, e.g. if liver and lung are both listed, then liver may have been a target in one experiment and lung in another.






N-Methylolacrylamide: All Experiments and Citations in CPDB





Chemical (Synonym) CAS

N-METHYLOLACRYLAMIDE (N-(hydroxymethyl)-acrylamide) 924-42-5 3993 M f b6c gav 24m24 TR352 : 0 17.5mg 35.0mg MXB MXB 27.8mg * P<.0005 15.8mg 89.4mg 14/50 20/50 37/50 hag:ade,anb; liv:hpa; lun:a/a,a/c; ova:gcb. C hag MXA 44.6mg * P<.0005 25.3mg 5/50 11/50 22/50 hag:ade,anb,car. S hag MXA 55.5mg * P<.002 c 29.9mg 5/50 8/50 20/50 hag:ade,anb. liv hpa 66.9mg / P<.0005 c 35.6mg 3/50 4/50 17/50 liv MXA 74.8mg * P<.009 35.7mg 2.08gm 6/50 7/50 17/50 liv:hpa,hpc. S ova gcb * P<.006 c 58.1mg 0/50 5/50 5/50 lun MXA * P<.06 c 45.2mg n.s.s. 6/50 8/50 13/50 lun:a/a,a/c. TBA MXB 30.9mg * P<.03 13.9mg n.s.s. 33/50 41/50 47/50 liv MXB 74.8mg * P<.009 35.7mg 2.08gm 6/50 7/50 17/50 liv:hpa,hpc,nnd. lun MXB * P<.06 45.2mg n.s.s. 6/50 8/50 13/50 lun:a/a,a/c. 3994 M m b6c gav 24m24 TR352 : 0 17.5mg 35.0mg MXB MXB 13.3mg * P<.0005 8.07mg 32.0mg 16/50 30/50 43/50 hag:ade; liv:hpa,hpc; lun:a/a,a/c. C hag MXA 17.4mg * P<.0005 11.4mg 30.6mg 2/50 14/50 30/50 hag:ade,car. S hag ade 17.5mg * P<.0005 c 11.7mg 29.4mg 1/50 14/50 29/50 liv MXA 29.4mg * P<.003 c 15.2mg 12/50 17/50 26/50 liv:hpa,hpc. lun MXA 38.5mg * P<.002 c 20.4mg 5/50 10/50 18/50 lun:a/a,a/c. liv hpa 50.2mg / P<.008 23.3mg 1.15gm 8/50 4/50 19/50 S lun a/a 66.0mg * P<.009 30.7mg 2.27gm 3/50 6/50 11/50 S lun a/c 75.1mg * P<.006 35.1mg 2/50 4/50 10/50 S liv hpc 63.4mg * P<.05 27.1mg n.s.s. 6/50 13/50 12/50 S TBA MXB 22.3mg * P<.02 10.2mg n.s.s. 35/50 39/50 47/50 liv MXB 29.4mg * P<.003 15.2mg 12/50 17/50 26/50 liv:hpa,hpc,nnd. lun MXB 38.5mg * P<.002 20.4mg 5/50 10/50 18/50 lun:a/a,a/c. 3995 R f f34 gav 24m24 TR352 : 0 4.20mg 8.41mg TBA MXB no dre P=1. - 6.33mg n.s.s. 45/50 36/50 42/50 liv MXB no dre P=1. n.s.s. n.s.s. 0/50 0/50 0/50 liv:hpa,hpc,nnd. 3996 R m f34 gav 24m24 TR352 : 0 4.20mg 8.41mg ski ker # 13.0mg \ P<.03 - 4.72mg n.s.s. 1/50 6/50 (3/50) S TBA MXB 3.12gm * P<1. 5.39mg n.s.s. 45/50 40/50 45/50 liv MXB no dre P=1. 11.0mg n.s.s. 4/50 2/50 (0/50) liv:hpa,hpc,nnd.

Mutagenicity in Salmonella: negative
SMILES Code for N-Methylolacrylamide: O=C(NCO)C=C
InChI Code for N-Methylolacrylamide: InChI=1/C4H7NO2/c1-2-4(7)5-3-6/h2,6H,1,3H2,(H,5,7)
Chemical Structure for N-Methylolacrylamide: Chemical Structure
Source for structure: National Library of Medicine ChemIDPlus





  3. Excel version of the same data.




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Last updated: October 3, 2007

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