The building now housing Midlothian Apothecary was originally constructed in the 1920s as a car dealership. It later became a grocery store, and then both a grocery store and a U.S. post office.

The pharmacy was started in the 1950s and shared space with the post office. The Darbys purchased the pharmacy in 1990, changing the name from Midlothian Pharmacy to Midlothian Apothecary to reflect their interest in the art of pharmacy practice.