I noticed it is much more effective for pain reduction than the other antidepressants. It's also obviously nice because it also treats depression and anxiety. My only problem with it related to fibromyalgia is that it worsens my insomnia a bit so I have to take Ambien at night to sleep. I think taking Cymbalta with Lyrica is more effective than taking just one alone. I'd rate pain reduction on Cymbalta a 7/10 Side effects I got: Nausea, insomnia, decreased appetite, and sexual dysfunction. The sexual dysfunction will go away if you take a dopaminergic drug along with it such as Wellbutrin