tipiracil and trifluridine

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Pronunciation: tye PIR a sil and trye FLURE i deen

Brand: Lonsurf

What is the most important information I should know about tipiracil and trifluridine?

Before and during your treatment with this medicine, you will need blood tests.

Call your doctor at once if you develop signs of infection (fever, chills, body aches).

What is tipiracil and trifluridine?

Tipiracil and trifluridine is a combination cancer medicine that interferes with the growth and spread of cancer cells in the body.

Tipiracil and trifluridine is used to treat colorectal cancer that has spread to other parts of the body (metastatic).

Tipiracil and trifluridine is usually given after other cancer medicines have been tried without success.

Tipiracil and trifluridine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking tipiracil and trifluridine?

You should not use this medicine if you are allergic to tipiracil or trifluridine.

To make sure tipiracil and trifluridine is safe for you, tell your doctor if you have ever had:

  • kidney disease;
  • liver disease; or
  • if you are pregnant or may become pregnant.

Tipiracil and trifluridine can harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine, whether you are a man or a woman. Men should use condoms. The use of tipiracil and trifluridine by either parent may cause birth defects.


It is not known whether tipiracil and trifluridine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine, and for at least 24 hours after your last dose.

How should I take tipiracil and trifluridine?

Before and during your treatment with tipiracil and trifluridine, you will need blood tests. The timing of these tests is very important. Do not miss any scheduled appointments.


Tipiracil and trifluridine should be taken within 1 hour after your morning and evening meals.

Tipiracil and trifluridine is given in a 28-day treatment cycle. You may need to use the medicine only on certain days of each cycle. Your doctor will determine how long to treat you with this medicine.

Wash your hands after handling tipiracil and trifluridine tablets.

Caregivers who touch or handle the tablets should wear rubber gloves.

To get the correct dose, you may need to take 2 or more tablets that are different strengths and colors. Follow your doctor's dosing instructions very carefully.



If you do not store this medicine in the original container, you will need to throw away any unused tablets after 30 days.

What happens if I miss a dose?


What happens if I overdose?


What should I avoid while taking tipiracil and trifluridine?



What are the possible side effects of tipiracil and trifluridine?


Call your doctor at once if you have:

  • fever, chills, flu-like symptoms, swollen gums, painful mouth sores;

Serious side effects may be more likely in older adults.

Common side effects may include:

  • stomach pain, loss of appetite;
  • nausea, vomiting, diarrhea;
  • fever; or
  • feeling weak or tired.


What other drugs will affect tipiracil and trifluridine?

Other drugs may interact with tipiracil and trifluridine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about tipiracil and trifluridine.



Copyright 1996-2018 Cerner Multum, Inc. Version: 2.03. Revision date: 7/25/2017.
