The Avian Influenza Virus Polymerase Brings ANP32A Home to Roost

Mehle A (2016)

Avian influenza virus polymerases function poorly in mammals, restricting transmission across species and the emergence of pandemic outbreaks. We discuss new work from the Barclay lab implicating ANP32A as a crucial cellular protein that dictates species-specific polymerase activity.

Ubiquitination up-regulates influenza polymerase function

Kirui J, Mondal A, Mehle A. (2016)

Ubiquitination and the ubiquitin-proteasome pathway play key roles during multiple stages of influenza virus infection. We now show that these processes modulate viral polymerase activity independent of protein degradation.

Unusual influenza A viruses in bats

Mehle A (2014)

A brief review of the ancient lineage of influenza viruses recently found circulating in wild bat populations in Central and South American. We discuss the unique features of these viruses, their place in the evolution of Orthomyxoviridae and their potential (or not) to cause disease in humans.