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Albrecht, M.; Frungieri, M. B.; Kunz, Lars ORCID: 0000-0003-3141-0005; Ramsch, R.; Meineke, V.; Kohn, F. M.; Mayerhofer, Artur (2005): Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour. In: Cellular and Molecular Life Sciences, Vol. 62, No. 23: pp. 2867-2876
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Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca2+ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events.