@article {Almeida2473, author = {Almeida, Jorge R. and Price, David A. and Papagno, Laura and Arkoub, Za{\"\i}na A{\"\i}t and Sauce, Delphine and Bornstein, Ethan and Asher, Tedi E. and Samri, Assia and Schnuriger, Aur{\'e}lie and Theodorou, Ioannis and Costagliola, Dominique and Rouzioux, Christine and Agut, Henri and Marcelin, Anne-Genevi{\`e}ve and Douek, Daniel and Autran, Brigitte and Appay, Victor}, title = {Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover}, volume = {204}, number = {10}, pages = {2473--2485}, year = {2007}, doi = {10.1084/jem.20070784}, publisher = {Rockefeller University Press}, abstract = {The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV) infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in particular, the immunodominant p24 epitope KK10 correlate with control of HIV-1 replication in human histocompatibility leukocyte antigen (HLA){\textendash}B27 patients. To understand further the nature of CD8+ T cell{\textendash}mediated antiviral efficacy, we performed a comprehensive study of CD8+ T cells specific for the HLA-B27{\textendash}restricted epitope KK10 in chronic HIV-1 infection based on the use of multiparametric flow cytometry together with molecular clonotypic analysis and viral sequencing. We show that B27-KK10{\textendash}specific CD8+ T cells are characterized by polyfunctional capabilities, increased clonal turnover, and superior functional avidity. Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines.}, issn = {0022-1007}, URL = {http://jem.rupress.org/content/204/10/2473}, eprint = {http://jem.rupress.org/content/204/10/2473.full.pdf}, journal = {Journal of Experimental Medicine} }