TY - JOUR T1 - The mismatch negativity to frequency deviant stimuli during natural sleep. JF - Electroencephalogr Clin Neurophysiol Y1 - 1996 A1 - Loewy, D H A1 - Campbell, K B A1 - Celyne H Bastien KW - Acoustic Stimulation KW - Adult KW - Evoked Potentials, Auditory KW - Female KW - Humans KW - Sleep KW - Sleep Stages KW - Wakefulness AB -

Eight subjects spent a single night in the sleep laboratory. Event-related potentials (ERPs) were recorded during the presentation of two auditory "oddball' stimulus conditions in which tonal frequency was manipulated. In the first condition, 1000 Hz "standard' and 2000 Hz "deviant' tones were presented. In the second condition, the deviant tone was reduced to 1050 Hz. In both conditions, deviant probability was 0.2. Stimuli were presented every 600 ms during wakefulness and stages 2, 4, and REM of sleep. A distinctive N1 wave was visible in both stimulus conditions when the subject was awake. The deviant stimuli elicited a "mismatch negativity' (MMN) that inverted in polarity at the mastoid. In REM sleep, an N1 and a MMN were also elicited in both conditions. In the large deviance condition, the MMN had a slightly attenuated amplitude and was shorter in duration while in the small deviant condition, its peak latency was unusually early. Neither the N1 nor the MMN could be recorded in non-REM sleep.

VL - 98 IS - 6 U1 - http://www.ncbi.nlm.nih.gov/pubmed/8763509?dopt=Abstract ER -