﻿ A simulator of human physiology under energy balance in cells | Grygoryan | PROBLEMS IN PROGRAMMING

DOI: https://doi.org/10.15407/pp2018.04.093

A simulator of human physiology under energy balance in cells

R.D. Grygoryan, A.G. Degoda, E.A. Dzhurinsky, T.V. Aksenova


For IBM-compatible personal computers, a software simulator (PS) is created, based on simplified mathematical models (UMM) of complex physiological systems (CFS) that provide energy balance in human cells. The differential equations of the previously created and published dynamic model in UMM are replaced by algebraic equations describing the proportional dependences between the variables of the state of the CFS. UMMs describe only the statics of cellular and multicellular CFS. The PS developed in C ++ provides the user (physiologist) with an interface through which different combinations of specified state variables are selected to calculate the mean arterial pressure (SBP). Multidimensional equations contain coefficients characterizing the sensitivity of state variables to changes in the energy status of the organism. By means of numerical values of these coefficients the user can simulate different static physiological regimes of the organism. Examples of such computations are given. PS is a convenient information technology, complementing the traditional empirical methods of human physiology.

Problems in programming 2018; 4: 93-100



mathematical model; energy; physiology; arterial pressure; information technology

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Bassingthwaighte J.B. Strategies for the Physiome Project. Annals of Biomedical Engneering. 2000. N 28. P. 1043–1058.

Kohl P, Noble D. Systems biology and the virtual physiological human. Mol Syst Biol. 2009. N 5. P. 292–299. CrossRef


Grygoryan R.D. Energy concept of arterial pressure. Reports of the Nat. Acad. Sciences of Ukraine. 2011. N 7. P. 148–155.

Grygoryan R.D. The Energy Basis of Reversible Adaptation. New York, USA: Nova Science, 2012. 253 p.

Grygoryan R.D., Lyabach E.G. Arterial pressure: rethinking. Kiev: Institute of Software Systems of the NASU. Akademperiodika. 2015. 434 p.

Grygoryan R.D. Paradigm of "floating" blood pressure. Düsseldorf, Germany: Palmarium Academic Publishing. 2016. 417 p.

Grygoryan R.D. The Optimal Circulation: Cells' Contribution to Arterial Pressure. New York, USA: Nova Science. 2017. 279 p.

Grygoryan R.D., Sagach V.F. The concept of physiological supersystems: a new stage of integrative physiology. International J. of Physiol. And Pathophysiol. 2018, 9(2):P. 169–180. CrossRef

Grygoryan R.D., Aksenova T.V., Deriev I.I. Software simulator of aerobic cell reactions to energy imbalance. Problems in programming. 2014. N 1. P. 90–98.

Grygoryan R.D., Aksenova T.V., Degoda A.G. A computer simulator of mechanisms providing energy balance in human cells. Cybernetics and computer engineering. 2017. N 2 (188). P. 67–76.

Grygoryan R.D., Aksenova T.V., Degoda A.G. Modeling of mechanisms and hemo-dynamic effects of cardiac hypertrophy. Cybernetics and computer engineering. 2016. Iss. 184. P. 72–83.

DOI: https://doi.org/10.15407/pp2018.04.093


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