Protein/macromolecular crystallography

3D structure of large molecules for rational drug design

Protein/macromolecular crystallographyThis technique employs single crystal X-ray diffraction (SXRD) to unambiguously determine the three dimensional structure of large biological molecules. Pharmaceutical and biotechnology researchers need to understand how disease is controlled at the molecular level within proteins and related macromolecules so as to target specific entities based on this knowledge. A prerequisite for this approach is the ability to obtain a high-resolution 3D molecular structure of the macromolecule under investigation. Given the importance of this research, Rigaku has been at the forefront in the development of a wide range of instrumentation related to various aspects of macromolecular crystallography.


X-ray Diffraction systems
Synergy-R   XtaLAB Synergy-R
Single crystal X-ray diffractometer with MicroMax-007 HF microfocus rotating anode X-ray generator
  Synergy-S   XtaLAB Synergy-S
Fast, flexible single crystal X-ray diffractometer with the latest generation microfocus sources and HPC X-ray detectors, perfect for any crystallography lab.
Synergy Custom   XtaLAB Synergy Custom

SAXS systems 
BioSAXS-2000   BioSAXS-2000nano
Small angle X-ray scattering (SAXS) Kratky camera system
In Situ Crystallography 
XtalCheck   XtalCheck
Rigaku Reagents   Rigaku Reagents
Reagent kits, stock solutions, and accessories for
protein crystallography researchers



HyPix-6000HE detector HyPix-6000HE detector
Hybrid Photon Counting (HPC) detector offering direct X-ray photon counting, single pixel point spread function and extremely low noise
PILATUS3 R detectors PILATUS3 R detectors
 Automatic Sample Changer 
ACTOR   ACTOR sample changer
Automated crystal transport, orientation and retrieval robot

Protein X-ray crystallography is a powerful structural biology technique that provides atomic resolution details about proteins and other macromolecular molecules involved in all aspects of life and disease. Rigaku is a world leader in providing instrumentation that can improve productivity at many levels — from making crystallization solutions and growing crystals to automatically mounting crystals and collecting high resolution single crystal X-ray diffraction data sets. Please select a system or component of interest to find out how Rigaku can assist you in your protein crystallography research.