@article {657, title = {Follow-up of a major psychosis linkage site in 13q13-q14 reveals significant association in both case-control and family samples.}, journal = {Biol Psychiatry}, volume = {74}, year = {2013}, month = {2013 Sep 15}, pages = {444-50}, abstract = {



RESULTS: An association of the T allele of rs1156026 found in the case-control sample (odds ratio [OR] = 1.81, p = 4 {\texttimes} 10(-6), false discovery rate = .01) was replicated in the kindred sample (OR = 1.54, p = .01), strengthening the overall association evidence (p = 8 {\texttimes} 10(-7)). The effect size increased in the subset of unrelated patients with a family history (OR = 2.28) and in the 15 families where SZ was predominant (OR = 2.03). In the kindred sample, onset of either SZ or BD was, on average, 5 years earlier for T/T compared with C/C homozygotes, leading to stronger association in patients with onset before 26 years of age (SZ: OR = 2.40, p = 1.3 {\texttimes} 10(-4); SZ, BD, and schizoaffective disorder combined: OR = 1.87, p = 8 {\texttimes} 10(-5)).


}, issn = {1873-2402}, doi = {10.1016/j.biopsych.2013.03.004}, author = {Alexandre Bureau and Chagnon, Yvon C and Croteau, Jordie and Fournier, Alain and M-A Roy and Paccalet, Thomas and Chantal M{\'e}rette and Michel Maziade} }