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Market application trend of amino acid protectors

News Source：http://www.chicheroine.com/ ; SendDate：2019-6-12 11:22:03 

????In addition to the traditional protectors: benzyl chloroformate, chloroformate -P fluorene formate, there are some new protectors, such as di-tert-butyl dicarbonate, n-hydroxysuccinimide, 9-fluorene methyl-n-succinimide carbonate, etc.

????Di-tert-butyl dicarbonate, commonly known as BOC, whose molecular formula is C10H18O5, CAS number is 24424-99-5.Di-tert-butyl dicarbonate is used in organic synthesis to introduce tert-butyl carbonyl protection gene, especially for amino protection of amino acids. Widely used in medicine, protein and peptide synthesis, biochemical food, cosmetics and other products synthesis.

????1-hydroxypyrrolidine-2,5-dione, molecular formula: C4H5NO3, CAS no. : 6066-82-6. Carboxyl groups are activated for the formation of amide bonds. Used for synthesis of amino acid protectant, semi-synthetic kanamycin and pharmaceutical intermediates.

????N-(9-Fluorenylmethoxycarbonyloxy) succinimide, molecular formula: C19H15NO5, CAS no. : 82911-69-1. Used as amino acid protector, amino acid derivative reagent, fluorescence detection, reagent is more stable, no dipeptide and tripeptide impurities, and the reaction speed is faster. It is also a highly efficient selective reagent for the preparation of hydroxyl amino acid derivative N-(9- fluoroethyl methoxy carbonyl) and the synthesis of glycopeptide.

????The new protectant has many advantages over the traditional protectant. First, it can protect the amino acid very well. Second, they are highly safe and do not adversely affect our health. Finally, their prices are low and merchants can make a lot of money. Therefore, new protectors gradually replace other traditional protectors in the market of amino acid protectors, such as benzyl chloroformate, chloroformic acid -P fluorene formic acid, etc.

????However, the new protective agent also has its own advantages and disadvantages, as for the market from the safety and economic considerations of the new protective agent is more inclined to use which kind of product is beautiful and cheap, still to be investigated. At present, the market situation of di-tert-butyl carbonate is more favorable. Nanjing shunxiang as the first domestic research and development of new technology of tert-butyl ester carbonate, has been using independent factories, specializing in the production, and research and development mode of production, and through continuous accumulation of a large number of production and practice, make the products in quality, production safety, product yield of continued ascension in many aspects, especially the further optimization for product production process, raw materials, make the whole production process of the product to the environment pollution is almost zero.

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