HLA-DR Antigen

The human major histocompatibility complex (MHC), also called human leucocyte antigens (HLA), is composed of three groups of molecules designated MHC class I, class II and class III. The MHC class II genomic region, or HLA-D region, contains the genes encoding HLA-DR, -DQ and -DP antigens. The MHC class II molecules are built by the non-covalent association of α/β heterodimers. Both heavy (α) and light (β) chains span the cell membrane. They have molecular weights of 31-33 kDa and 26-29 kDa respectively. HLA-DR molecules are found on antigen-presenting cells (APC), i.e. dendritic cells, B lymphocytes, monocytes, macrophages, Langerhans cells and thymic epithelial cells. They are also expressed on activated T cells, but not on granulocytes, platelets, or red blood cells. Resting T cells or endothelial cells that do not normally express these molecules can be induced to express them. HLA-DR is also expressed on some hematopoietic progenitor cells at different stages of differentiation.

Clone: B8.12.2

 Isotype: IgG2b Mouse

HLA-DR antibodies are specific to non polymorphic determinants of human HLA class II DR molecules which are constituted of α and β polypeptides of 34 and 29 kDa respectively.

Clone: Immu-357 Isotype: IgG1 Mouse

Choose a HLA-DR Model

Product Line Specifications

Format Liquid
Specificity HLA-DR
Form ECD
Clone Immu-357
Isotype IgG1 Mouse
Cross Reactivity Cynomolgus Monkey, Indian Rhesus, Hamadyras Baboon, Olive Baboon, Capuchin Monkey, Cotton-topped Tamarin
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced IM3636


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