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Structural Biology Points Way to Coronavirus Vaccine

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Spike Protein on Novel Coronavirus
Credit: McLellan Lab, University of Texas at Austin




















Coronaviruses (National Institute of Allergy and Infectious Diseases/NIH)

Coronavirus (COVID-19) (NIAID)


NIH Support: National Institute of Allergy and Infectious Diseases


  • Linda Robinson says:

    Is there any chance that the corona virus we are now fighting is somehow related to nutrition? I know it sounds ridiculously simple. But if you study over the country’s around the world, those having very large increase, and the ones very low. It almost seems it’s not wreking havoc as much on countries that rely on a diet of rice, chicken, pork. Not nearly as much gluten as countries that rely on wheat (pasta) meals. Gluten is known to produce inflammation in the gut where our resistance begins. I know, the pandemic started in China. . . Rice capital? But it only began there. . . If it had been contained there, well I guess we’ll never know because it wasn’t contained. Ok. But just at least LOOK at the data and groups of countries. There may be something there. . .

    • John Hasty says:

      Long term good health and a strong immune system is related to diet. People with a strong immune system will naturally handle an infection better. The problem is when a person who can handle the infection runs around town coming in contact with people with weaker immunity.

    • Yonis says:

      I think that probably should be a good idea to practice with cell from animals that have high ratio of regeneration, combining them and use it against the covid19. We have to try everything.

    • Wayne Johnson says:

      That sounds reasonable Linda. Italy,spain, United states, France, Germany have a high intake of gluten and sugary junk food. Vietnam, Singapore, Taiwan,China,more rice and chicken,pork and veges.
      And low death rates considering China eats bat meat.

  • Juan Carlos Manay says:

    I was thinking that sometimes Nature has its particularly ways.. since the COVID19 has now the possibility of infected animals; why not infect the bat where originally exists. Since it is the same virus but modified, we could use the immunology system of the bat to get the antibody for the COVID 19.
    Where the disease was born, the solution could also be found.

    • Yonis says:

      We have to think that bats are the same as rats. The urine or feces of these small rodents can infect us with unthinkable diseases for example, touching a dead mouse or bat can bring health problems, eating these animals is a risk and is even greater if the meat that was eaten was poorly undercooked or not properly cleaned.

      Some of the diseases caused by rodents and probably bats are:

      1. Tularemia.


      3. Leptospirosis.

      4. Teniasis.

      5. Trichinosis.

      6. Toxoplasmosis.

      Most of them have treatment and clinical manifestations are similar or almost the same to covid19.

      The treatment for tularemia is: streptomycin. It can also be treated with quinolones, gentamicin, tetracyclines, or chloramphenicol.
      Please find more information about the diseases that I have shown and use it against covid19. I hope this information will help.

  • Mike Nuccio says:

    In the research, are we looking into oral or nasal inhalation as route for current (and future) antivirals? Plenty of previous studies with influenza.

  • sumith tito says:

    try a mixture of turmeric and dry ginger power and u can chew raw ginger so that the sulphur group is not destroyed…

  • Saadullah says:

    I think own way
    If reaserchers do that thing
    If we combain sliymarin with chloroquin for treatment
    Vaccine ( combien blood plazma who recover from covid 19 pateints with silymarin.chloroquin and vitamins

  • Kerry B. says:

    Any chance breast milk containing antibodies would help? As a hospital nurse with a breastfed infant, I feel like an untapped resource.

  • Juan Carlos Manay says:

    Since COVID 19 has an affinity for ACE, how about using a medication that blocks its substrate well above the chain ( angiotensinogen to angiotensin I), that is using aliskiren.
    Wouldn’t I reduce the expressión of ACE and thus the site of binding of COVID19.

  • Vic Vorobieff says:

    The UK “The Times” newspaper of April 4, 2020, reports that once the coronavirus enters our body, our immune system develops antibodies to kill the virus and in some/most instances it succeeds and the infected person continues to live.
    I am curious as to what happens to the carcass of the dead coronavirus and namely, does it remain in the body or does the body eject it by expiration, urination and/or defecation?

    Secondly, there is a World Health Organisation (WHO) poster that shows COVID-19 droplets (subsequent to coughing, sneezing, etc) have a longevity lasting from 3 hours in the air, 4 hours on copper surfaces, 24 hours on carboard food containers and up 9 days on glass and mobile phones.
    Government and health authorities informs us that we should use soap and water or an alcohol-based sanitizer/disinfectant to kill the COVID-19 droplets; (and I have been following such advice). However, we do not regularly wash/sanitise our air, disposed food containers and mobile phones.
    But what happens when these exhaled droplets are released in the wild (ie bush land or farm lands). How does nature kill these droplets; and namely, is it through sunlight (ultraviolet light), or heat or cold or moisture (ie water) or is soil and flora poisonous to it?

  • HERIEL E says:

    There are ideas from those who know about medical issue from different places in the world, can NIH support and working with these ideas and with those who provides their comments ?? Because I have more reasonable and suggestions of drugs which it can help prevent COVID19 ,those drugs are in the following groups first in immune system booster drugs, corticosteroids,and antibiotics,, I will cooperate if there is chance.

  • Maureen Grey says:

    Has anyone looked into the Ultraviolet Irradiation of Blood as a treatment?

  • Katherine says:

    I will continue to research this issue but had a question regarding the antibody test. Could patients having autoimmune issues be candidates in vaccines development.

  • Aguilar Rodarte Orlando says:

    What kind of information could provide the genome of people infected with Covid-19??

  • Dr.Luciano A. Pulido says:

    It is encomiastic the effort of the VRC and the NIAID to find a vaccine to combat the effect of the SARS CoV-2. Even the comments made in this blog are eulogistic efforts to contribute to fighting the COVID-19. But we cannot lose the vital fact that all these contributions are talking about a mechanical process, which is a result or manifestation of the actions of molecules on other molecules under the influences of forces and structures of information. This process is then effective as emergency medicine. Life is natural in its continuum process. Therefore it does not imply a continuum “emergency” solution for unpredictable temporal interruption of its flow. Life requires a crucial understanding of its quantum essence. Man is an open system, along with its environmental nature. So, his internal physiological processes are quantum as well. The description of the interaction of molecules like billiard balls on a table gives us a fake illusion of the critical situation that we are living. Molecules and atoms are not like that. So, in this way, we cannot meet the root cause of the pandemic coronavirus aggressive spread. Let alone to explain why persons who haven’t tripped to china or any other country and have not had contact with others who are infected now are sick with the COVID-19. To find a clear cause based on a scientific theory for such a fast spread of the coronavirus effect is a priority.
    Molecular Biology cannot give that scientific epistemological support anymore. It doesn’t even explain clearly the structural nature of a molecule or an atom neither their quantum property to act. Quantum physics has given that theoretical support since a century ago. It is the time of not looking down those important scientific pieces of evidence that gurus of Physics passed to us last century. Men like Neil Bohr, Werner Heisenberg, Louis de Broglie, Max Born, Schrodinger, Max Planck, John Vonn Newmann John Archibald Wheeler, and even Albert Einstein provided valuable information to understand the biology and support the medicine. To remain ignoring their legacy, it would be like to keep pulling a train with horses when now we have a locomotive to do that work. Einstein said that insanity was to keep doing the same thing and to want a different result. We won’t have a different outcome to end the pandemic period if we keep looking at the particle as the critical point of analysis.
    There is a crucial element missed in this equation, consciousness, which is not an epiphenomenon of matter. There is no scientific evidence that supports that approach. A molecule like a virus cannot act by itself to cause damage. For the virus to bind a receptor on human cells, its spike protein has to suffer several steps of conformational changes to allow the reading of its coded genetic material during membrane fusion. This process takes place when environmental signals work as attractor patterns that resonate with the frequencies emitted by the virus. It is time to start considering studies on morphic resonance, morphogenetic fields, chaos theory with its Lorentz’s butterfly effects, quantum entanglement, and some other already proved quantum principles to understand thoroughly the COVID-19 whole picture. Leonard Susskind stated that we should have learned quantum physics first before classic physics if we wanted a reasonable understanding of life. To meet an effective end of the pandemic and the chaos it brought about, all the responsible institutions to find it has to think of integrating the classical emergency approach of conventional medicine with the quantum natural holistic one. I’m sure we’ll come to terms with a new central dogma that better support the understanding of life.

    • Jose DAmorim says:

      Hi, Dr Pulido, I am a physician from Argentina, and I totally agree with your statement. I would like to connect with you, for instance, on facebook.

  • mc says:

    It’s really a useful blog. Thank you keep sharing.

  • Betty McKinstry says:

    Are BOOP and COVID-19 much the same?

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