@article {1551, title = {Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation.}, journal = {The EMBO journal}, volume = {27}, year = {2008}, month = {2008 Jun 4}, pages = {1563-74}, abstract = {

In response to stimuli that activate p53, cells can undergo either apoptosis or cell cycle arrest, depending on the precise pattern of p53 target genes that is activated. We show here that Zbtb4, a transcriptional repressor protein, associates with the Sin3/histone deacetylase co-repressor and represses expression of P21CIP1 as part of a heterodimeric complex with Miz1. In vivo, expression of ZBTB4 is downregulated in advanced stages of multiple human tumours. In cell culture, depletion of ZBTB4 promotes cell cycle arrest in response to activation of p53 and suppresses apoptosis through regulation of P21CIP1, thereby promoting long-term cell survival. Our data suggest that Zbtb4 is a critical determinant of the cellular response to p53 activation and reinforce the notion that p21Cip1 can provide an essential survival signal in cells with activated p53.

}, keywords = {2008, APOPTOSIS, Basic Sciences Division, cell cycle, Center-Authored Paper, Child, Cyclin-Dependent Kinase Inhibitor p21, DNA-Binding Proteins, DOWN-REGULATION, Gene Expression Regulation, Genomics Core Facility, Humans, Kruppel-Like Transcription Factors, Neoplasms, Promoter Regions, Genetic, Repressor Proteins, Shared Resources, TRANSCRIPTION FACTORS, Transcription, Genetic, Tumor Cells, Cultured, Tumor Suppressor Protein p53}, issn = {1460-2075}, author = {Weber, Axel and Marquardt, Judith and Elzi, David and Forster, Nicole and Starke, Sven and Glaum, Andre and Yamada, Daisuke and Defossez, Pierre-Antoine and Delrow, Jeffrey J and Eisenman, Robert N and Christiansen, Holger and Eilers, Martin} }