Cleveland Heartlab A, Inflammation, New Tests, Test

CPT Code: 82542
Order Code: C301
ABN Requirement: No
Specimen: Serum
Volume:  1.0 mL
Minimum Volume:  0.5 mL
Fasting: Fasting is recommended but not required
Container: Gel-barrier tube (SST, Tiger Top)


  1. Collect and label sample according to standard protocols.
  3. Allow blood to clot 30 minutes.
  4. Centrifuge for 10 minutes.



Ambient (15-25°C): 1 day
Refrigerated (2-8°C):
7 days
Frozen (-20°C):
193 days
Deep Frozen (-70°C):
193 days


Methodology: Tandem Mass Spectrometry (LC-MS/MS)

Turn Around Time: 5 days

Reference Range:

Analyte Age Low Relative Risk
Moderate Relative Risk
High Relative Risk
ADMA All Ages <100 100-123 >123


Analyte Age ng/mL
SDMA All Ages 73-135


Clinical Use: ADMA and SDMA may be measured in individuals with multiple risk factors for the development of cardiovascular disease.

Interpretive Information: Elevated ADMA levels are associated with significant subclinical atherosclerosis1,2 while elevated SDMA levels are associated with impaired kidney function3,4 and strongly correlate with reduced eGFR.4


  1. Maas, Renke, et al. Stroke 2009; 40: 2715-2719.
  2. Iribarren, Carlos, et al. Eur J Cardio Prev Rehab. 2007; 14: 222-229.
  3. Schepers, Eva, et al. Clin J Amer Soc Nephrol. 2011; 6: 2374-2383.
  4. Kielstein, Jan T., et al. J Am Soc Nephrol. 2002; 13: 170-176.
