KnowVolution and PePevo

The Peptide Polymer Evolution (PePevo) technology makes it possible to tailor polymer binding anchor peptides to bind efficiently under application conditions.

The protocol enables anchor peptide evolution through a special polymerase with a high mutation frequency (60 mutations per kilobase), which was developed at the chair for biotechnology at the RWTH Aachen. The polymerase is capable to generate sufficient diversity in short sequences as those of anchor peptides.

Through combining the PePevo and KnowVolution (knowledge-gaining directed evolution) techniques, the binding strength of an anchor peptide to a specific surface was increased considerably (5.2-fold).

Contact us for anchor peptides tailored to your application.