TY - JOUR T1 - Haem, not Protein or Inorganic Iron, Is Responsible for Endogenous Intestinal <strong><em>N</em></strong>-Nitrosation Arising from Red Meat JF - Cancer Research JO - Cancer Res SP - 2358 LP - 2360 VL - 63 IS - 10 AU - Cross, Amanda Jane AU - Pollock, Jim R. A. AU - Bingham, Sheila Anne Y1 - 2003/05/15 UR - http://cancerres.aacrjournals.org/content/63/10/2358.abstract N2 - Many N-nitroso compounds (NOC) are carcinogens. In this controlled study of 21 healthy male volunteers, levels of NOC on a high (420 grams) red meat diet were significantly greater (P = 0.001) than on a low (60 grams) meat diet but not significantly greater when an equivalent amount of vegetable protein was fed. An 8-mg supplement of haem iron also increased fecal NOC (P = 0.006) compared with the low meat diet, but 35-mg ferrous iron had no effect. Endogenous N-nitrosation, arising from ingestion of haem but not inorganic iron or protein, may account for the increased risk associated with red meat consumption in colorectal cancer. ©2003 American Association for Cancer Research. ER -