Trifluoromethanesulfonic Anhydride:  

Trifluoromethanesulfonic anhydride (abbreviation: Tf2O) is a very widely used reagent in organic synthesis. It is often used in the synthesis of trifluoroformate compounds, such as trifluoromethanesulfonate and triflate. Triflates is a very good leaving group, so after the organic substrate is treated with Tf2O and converted into the corresponding trifluoromethanesulfonate, the reactivity can be greatly enhanced and it is easy to achieve. Conversion to other organic compounds, such as palladium-catalyzed coupling reactions and nucleophilic substitution reactions.


Trifluoromethanesulfonic Anhydride:

CAS NO.: 358-23-6

Molecular formula: C2F6O5S2

Appearance: Colorless liquid

Purity: 99% Min.

Molecular weight: 282.14

EINECS NO.: 206-616-8



Test ItemStandard
AppearanceColorless liquid
Content99% Min.
Free Fluorde (As F-), ppmw50 Max.
CF3SO3H0.5% Max.


Use Of Trifluoromethanesulfonic Anhydride:      

As an intermediate, it is widely used in the pharmaceutical industry, proteins, sugars, vitamins, etc. Friedel-Crafts benzylation and cyclohexylation catalysts.

The plastic industry is used to catalyze chemical synthesis reactions as oligomerization polymerization catalysts and silicone rubber modification.

Electronic chemical industry for the production of electronic conductive polymers

The fuel industry is used as a catalyst for protonation reactions.

Agrochemical industry synthesize weeding and growth regulators.

Used in the sugar industry. Laboratory research for special reactions.


Package of Trifluoromethanesulfonic Anhydride:



Storage: Stored at RT.