Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)

CPT Code: 86664
Order Code: C1391
ABN Requirement: No
Synonyms: EBV Nuclear Antigen Antibody, EBV Past Infection, EBV NA
Specimen: Serum
Volume:  1.0 mL
Minimum Volume:  0.5 mL
Container: Gel-barrier tube (SST, Tiger Top)



  1. Collect and label sample according to standard protocols.
  4. Centrifuge for 10 minutes.



Ambient (15-25°C): 4 days
Refrigerated (2-8°C): 
7 days
Frozen (-20°C): 
30 days


Methodology: Immunoassay (IA)

Turn Around Time: 3-4 days

Reference Range:

U/mL Interpretation
<18.00 Negative
18.00-21.99 Equivocal
>21.99 Positive

Clinical Significance
: Primary infection by EBV causes infectious mononucleosis, usually a self-limiting disease in children and young adults. Infection with EBV can cause lymphoproliferative disorders including tumors. EBNA IgG typically appears during convalescence (3-4 months after clinical presentation) and remains detectable for life. VCA-IgM positivity in the absence of EBNA IgG suggests recent, active infection.
