Corpus ID: 24645977

[Synthesis and teratogenic action of n-hydroxythalidomide].

  title={[Synthesis and teratogenic action of n-hydroxythalidomide].},
  author={G. Blaschke and H. Hess and N. L{\"u}pke},
  volume={39 3},
N-Hydroxythalidomide (1d), a potential metabolite of thalidomide (1a), was synthesized from N-phthalyglutaminic acid anhydride (1b) and O-tetrahydropyraline hydroxylamine, followed by deprotection. The teratogenicity of 1d was studied using the Hen's-Egg-Test model which had been found applicable for 1a. 1d was more teratogenic to chicken embryos compared to 1a. The percentage of teratogenic malformations in the 1d groups was 28-46%, whereas the percentage in the 1a groups was 20-23%. The… Expand
4 Citations
Investigation of N-hydroxythalidomide in vitro stability and comparison to other N-substituted derivatives.
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A novel solid-phase synthesis of thalidomide and its metabolites and analogues is described, which involves the coupling of hydroxymethyl polystyrene with phthalic anhydride to form the resin-linked acid. Expand
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