Archivo Digital UPM: No conditions. Results ordered -Date Deposited. 2021-12-03T16:38:18Z EPrints 2018-12-12T11:27:16Z 2019-06-03T11:33:31Z This item is in the repository with the URL: 2018-12-12T11:27:16Z Competition among networks highlights the power of the weak The unpreventable connections between real networked systems have recently called for an examination of percolation, diffusion or synchronization phenomena in multilayer networks. Here we use network science and game theory to explore interactions in networks-of-networks and model these as a game for gaining importance. We propose a viewpoint where networks choose the connection strategies, in contrast with classical approaches where nodes are the active players. Specifically, we investigate how creating paths between networks leads to different Nash equilibria that determine their structural and dynamical properties. In a wide variety of cases, selecting adequate connections leads to a cooperative solution that allows weak networks to overcome the strongest opponent. Counterintuitively, each weak network can induce a global transition to such cooperative configuration regardless of the actions of the strongest network. This power of the weak reveals a critical dominance of the underdogs in the fate of networks-of-networks. Javier Iranzo Javier Martín Buldú Jacobo Aguirre 2017-03-27T11:59:52Z 2017-03-27T11:59:52Z This item is in the repository with the URL: 2017-03-27T11:59:52Z Dynamical community structure of populations evolving on genotype networks Neutral evolutionary dynamics of replicators occurs on large and heterogeneous networks of genotypes. These networks, formed by all genotypes that yield the same phenotype, have a complex architecture that conditions the molecular composition of populations and their movements on genome spaces. Here we consider as an example the case of populations evolving on RNA secondary structure neutral networks and study the community structure of the network revealed through dynamical properties of the population at equilibrium and during adaptive transients. We unveil a rich hierarchical community structure that, eventually, can be traced back to the non-trivial relationship between RNA secondary structure and sequence composition. We demonstrate that usual measures of modularity that only take into account the static, topological structure of networks, cannot identify the community structure disclosed by population dynamics. José Ángel Capitán Gómez Jacobo Aguirre Susanna Manrubia 2013-07-05T13:30:02Z 2016-04-21T16:30:37Z This item is in the repository with the URL: 2013-07-05T13:30:02Z Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens. Aranzazu Palacín Gómez Cristina Gomez Casado Luis Rivas Jacobo Aguirre Leticia Tordesillas Villuendas Joan Bartra Carlos Blanco Teresa Carrillo Javier Cuesta-Herranz Consolación de Frutos Genoveva García Álvarez-Eire Francisco Fernández P.M. Gamboa Rosa Muñoz Rosa Sánchez-Monge Laguna de Rins Sofía Sirvent María Torres Susana Varela Losada Rosalía Rodríguez Victor Parro Miguel Blanca Gabriel Salcedo Duran Araceli Díaz Perales 2013-07-04T17:26:29Z 2016-04-21T16:30:41Z This item is in the repository with the URL: 2013-07-04T17:26:29Z The involvement of thaumatin-like proteins in plant food cross-reactivity: a multicenter study using a specific protein microarray. Cross-reactivity of plant foods is an important phenomenon in allergy, with geographical variations with respect to the number and prevalence of the allergens involved in this process, whose complexity requires detailed studies. We have addressed the role of thaumatin-like proteins (TLPs) in cross-reactivity between fruit and pollen allergies. A representative panel of 16 purified TLPs was printed onto an allergen microarray. The proteins selected belonged to the sources most frequently associated with peach allergy in representative regions of Spain. Sera from two groups of well characterized patients, one with allergy to Rosaceae fruit (FAG) and another against pollens but tolerant to food-plant allergens (PAG), were obtained from seven geographical areas with different environmental pollen profiles. Cross-reactivity between members of this family was demonstrated by inhibition assays. Only 6 out of 16 purified TLPs showed noticeable allergenic activity in the studied populations. Pru p 2.0201, the peach TLP (41%), chestnut TLP (24%) and plane pollen TLP (22%) proved to be allergens of probable relevance to fruit allergy, being mainly associated with pollen sensitization, and strongly linked to specific geographical areas such as Barcelona, Bilbao, the Canary Islands and Madrid. The patients exhibited mayor que50% positive response to Pru p 2.0201 and to chestnut TLP in these specific areas. Therefore, their recognition patterns were associated with the geographical area, suggesting a role for pollen in the sensitization of these allergens. Finally, the co-sensitizations of patients considering pairs of TLP allergens were analyzed by using the co-sensitization graph associated with an allergen microarray immunoassay. Our data indicate that TLPs are significant allergens in plant food allergy and should be considered when diagnosing and treating pollen-food allergy. Aranzazu Palacín Gómez Cristina Gomez Casado Leticia Tordesillas Villuendas Rosa Sánchez-Monge Laguna de Rins Araceli Díaz Perales Luis Rivas Jacobo Aguirre Joan Bartra Carlos Blanco Teresa Carrillo Javier Cuesta-Herranz Jose Cumplido Bonny Enrique Flores Mar García-Álvarez Eire Ignacio García-Núñez Francisco Fernández P.M. Gamboa Rosa Muñoz María Torres Susana Varela Losada M. Villalba Francisco Vega Victor Parro Miguel Blanca Gabriel Salcedo Duran