Version 2.67

82451-6U1 small nuclear ribonucleoprotein A Ab [Presence] in Serum by Line blotActive

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP71719-6   U1 small nuclear ribonucleoprotein A
U1 small nuclear ribonucleoprotein particle (U1 snRNP) is an RNA-protein complex that is composed of ten proteins: U1–70kD, U1A, U1C and seven Smith antigen (Sm) proteins. The U1 snRNP complex is responsible for pre-mRNA processing. Autoantibodies to different components of the U1 snRNP complex are associated with autoimmune conditions including systemic lupus erythematosus (SLE) and mixed connective tissue disorders (MCTD), which includes systemic sclerosis. The pattern of autoantibodies present in an individual patient may help distinguish between different connective tissue disorders. For example, patients with anti-U1A and anti-U1C IgM antibodies are more likely to have SLE than MCTD. [PMID: 24158973] In addition, there is some evidence that specific antibody patterns are associated with specific symptoms. For example, among patients with SLE, the combination of anti-U1-70kD, anti-U1A and anti-U1C correlates with Raynaud's phenomenon, while anti-U1-70kD and anti-U1A (without anti-U1C) correlate with leukopenia. Another study found an association between the number of specific positive antibodies within the anti-U1 snRNP (rather than the presence of particular markers) and certain clinical features. For example, patients with three or more positive autoantibodies were more likely to have features of systemic sclerosis and less likely to have renal disease compared to patients with fewer types of antibodies. [PMID: 20015915] Source: Regenstrief LOINC, PMID: 24158973

Fully-Specified Name

U1 small nuclear ribonucleoprotein A Ab
Line blot

Additional Names

Short Name
U1 snRNP-A Ab Ser Ql Line blot
Display Name
U1 small nuclear ribonucleoprotein A Ab Line blot Ql (S)

Basic Attributes

First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID

Member of these Panels

LOINC Long Common Name
88883-4 Autoimmune connective tissue Ab panel - Serum by Line blot

Member of these Groups

LG21924-2 U1 small nuclear ribonucleoprotein A Ab|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (CHINA)
U1 小细胞核核糖核蛋白 A 抗体:存在情况或阈值:时间点:血清:序数型:线点印迹法
u1 small nucleair ribonucleoproteïne A As:aanwezigheid:moment:serum:ordinaal:lijnblot
fr-CAFrench (CANADA)
Petite particule nucléaire ribonucléoprotéique U1 A , Ac:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FRFrench (FRANCE)
U1 RNP A anticorps:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
de-ATGerman (AUSTRIA)
U1-snRNP-A-AK ql. IA
es-ESSpanish (SPAIN)
U1 ribonucleoproteína nuclear pequeña A Anticuerpos:PrThr:Punto temporal:Suero:Ord:Line blot

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