"25 year old female. I Love IT. I take 150 SR ONCE a day.  I did TONS of research that completely contradicted the information that ONLY &quot;300MG&quot; and higher MG&#039;s treat depression. Dr&#039;s all over the country disagree, so if your having negative side effects from high dose than simply try a lower dose. If your body responds well to higher MG then stay on it.  Another thing, I have read countless reviews that the first week or so is always the hardest, press through it (unless you are suicidal of course). I experienced BAD symptoms my 1st two weeks and then poof they subsided and I feel GREAT! Energy, positivity, increased libido, mental focus, NO weight gain and NO increased blood pressure. 150mg SR ONCE a day ROCKS."