"It&#039;s hard for a patient to &#039;rate&#039; a medication. I have an excellent cardiologist whose job that is.  However, I know that Toprol comes with a tendency toward depression for many people, and for me, pre-existing depression has been mildly exacerbated. I also take amlodipine since May of last year, and this is a drug also known to cause/increase depression. I take several other anti-hypertensive drugs therefore it is not easy to tell which is causing what.  Welcome to life post-cardiac bypass surgery--a life diminished, trust me, but at least--LIFE."