Migraine
"I too received a Reglan (metroclopramide) with Benadryl IV when treated in the ER. I was warned that this medication would make me extremely drowsy and it did. I also have to say I felt an extreme restlessness almost as instantly as I felt the medication reach my veins. I remember my husband holding my hand and rubbing my back and telling me to settle down because I became antsy. I was thrashing a little and tossing and turning in the bed. I think we experience this because the medication comes on so strongly and your first instinct is to try to fight how you&#039;re feeling and it gives you extreme fatigue which I believe gives a false sensation or dizziness and that you&#039;re falling which I believe is what causes the anxiousness and restlessnes."