"I was on Seroquel XR 350 mg for 3 years to treat clinical depression and anxiety. The only problems were the weight gain (about 80 pounds in 3 years), a general &quot;zombie&quot; feeling that made concentrating a little difficult, and some short-term memory problems but all of that was worth it since my moods were finally stable. Come to find out I was misdiagnosed and now I&#039;m being treated with Topamax for Bipolar II, but if that doesn&#039;t work, it&#039;s back to Seroquel. I suggest trying it to anyone who hasn&#039;t had luck with other medications. Once you get past 150 mg it might knock you out pretty quick, so take it at night and give yourself enough time for a solid 8 hours because you might not wake up before that."