Pain
"Good long-term analgesia with the extended release formula, which seems to work for over 8 hours, though I don&#039;t think it has the full 12-hour benefit as advertised. Less &#039;fuzziness&#039; than oxycodone (or even hydrocodone), which is a positive for me. I suppose it&#039;s not so good for &quot;recreational&quot; users - the new ER formula is supposed to be highly abuse-proof - but for those is REAL chronic pain, Opana-ER works well, similar to Oxycontin, and is very easy to use - one dose in the morning, another in the evening."