"I have only been on Tri-Sprintec for 20 days now so I am trying to give it a little longer, as I know it takes a while for your body to regulate it. However, it is very hard. I went from being very happy to depressed and moody within a week of starting it. I now have very little patience, which makes me feel terrible, especially because I have a dog and work with children and I want to be patient with them. I also have had an increase in acne since starting it. Painful cramps (which is why this was prescribed to me in the first place--to eliminate cramps) and weight gain. The worst part is that I have had a full period for 20 days straight, not just spotting. This pill is negatively effecting my life and my relationship. I hate it."