"Diagnosed with hypothyroidism, hypoglycemia, and POS.  I had classic symptoms for over the last 20 yrs (excessive hair growth (most embarrassing), fertility issues, and obesity). I could not loose weight no matter what I did. Only the last 7 yrs, have I received good medical care such as working with a nutritionist. With Synthroid increase to 150 mg over those 7 yrs, some symptoms got better but not the weight. I tried Contrave nervously. It took me a long time to get to the full dose, but the effects have been great: I&#039;ve lost 20 lbs slowly, my extremities are not as cold (I can eat salad in the winter), my inflammation, energy, and depression has improved significantly.  I am sure some of this is the result of loosing weight."