"I was shocked how fast this worked.  I&#039;ve been a long distance runner for years but have gradually gained weight thanks to menopause and occasional binge eating.  Had to stop running (or even walking) for 8 months because of ankle tendon tear and gained even more weight, plus many of my joints became very stiff and achy - especially in the mornings.  My ankle finally healed, and I tried to return to simple walking - I was in constant pain when I moved, ankles, knees, lower back.  Ibuprofen bothered my stomach.  I tried SAMe (a 400mg tablet) and 3 hours later the pain was 80% gone.  I&#039;ve continued it (400mg twice a day) for 2 months now and am walking again.  Added benefit - it&#039;s helped me lose weight (no more feelings like I want to binge)."