Depression
"First, tramadol is NOT an opiate, it may work somehow (no one knows how nor can claim to understand how) with receptors for them in the brain but please stop the completely false statements that this is an opiate-simply not true. 

Ultram was first used for in the 1990s was pain and then it became clear that if was also helpful for people who were not getting relief from anti-depressants (and did big Pharma push out every variation of SSRI uptake inhibitor at great cost to the public and of course with no clue if they would work). 

EXCELLENT alternative to ineffective anti-depressants that big pharma wants to keep pushing.  Again, wrong to even begin to compare it to an opiate, and time for it to be acknowledged as an option for depression."