"Started at 37.5 for hot flashes but also found that my hair trigger anger and low grade depression were gone.  Oh, did I mention the onset of suicidal Ideation I experienced at menopause?  Took care of that too.  Went up to 150xr a day, but stomach upset, excessive teeth grinding, loss of libido and weight gain are making me go back to 37.5 again.  Ended up on the 150 cause  of  my wicked hot flashes.....but willing to deal w them at 37.5 for the sake of my sex life.  I&#039;m afraid to go off of it at 37.5, as it removed the anxiety and despair I realized I have felt most of my life.  I encourage many to stay at the lowest dose of any of these drugs; it takes time to figure out which one is good for you.  Cheers"