"I have been on Depo for a year and now I think it would be good to take a break. After about 3 injections I saw no sign of a period whatsoever, but after about a year I have gained about 10lbs and some minor acne. BUT- I had terrible heavy periods that I would throw up from the pain from before, and Depo elimnated my pain and really helped me be more functional. It did change my mood, I have been a little depressed over the last year so I think that while I can safely be off birth-control I should for a while. It worked great as a birth control and saved me from my periods. What I&#039;ve heard about not getting your period back for a while and bone density loss does worry me, I&#039;ll definitely use Depo again though. SO CONVENIENT."