Depression
"I have tried over 20 different medications, and Trintellix is the best fit for me. I always describe its effect for me as &quot;being able to turn everything down in my head.&quot; I can see how this might not be a good fit for others as it might certainly aggravate &quot;feeling nothing&quot; or &quot;feeling detached.&quot; However, as my issue is primarily that I feel TOO much and am unable to step back from my emotions and intrusive, racing thoughts, Trintellix&#039;s &quot;detachment&quot; is extremely helpful for me. 

I do get nausea for the first week upon taking Trinellix or upping my dosage; however, this subsides for me. I was on 10mg for 8 months and have now increased my dosage to 20mg in hopes of it being even more effective."