Depression
"I took Effexor XR 150mg for a good 10 years for depression.  Then, I switched to Zoloft due to what is considered a side-effect of Effexor:  elevated liver enzymes.  On Zoloft, I felt more anxious than I did on Effexor, but not overly so.  It was tolerable.   I continued to have same liver enzymes while on Zoloft.   It turns out the enzyme issue is not related to the medication alone, if at all.  I had a stressful life changing event and felt very anxious.  I know I felt much less anxious on Effexor so I asked to be switched back and I was.  The doctor made a general statement that he wants me on what works best for me.  However, I&#039;m pretty sure he didn&#039;t buy my anxiety theory. "