Irritable Bowel Syndrome
"Physicians are way too excited about Linzess.  It definitely does not work for everyone and not exactly as indicated.  The first three days I took it were fine.  Then no effect for two days.  Then incredible pain.  I asked the doctor if I could try a lower dose.  Was advised to take it at bedtime!?  Definitely not a good idea when part of the problem was extreme diarrhea.  Quit taking it for two weeks.  Went back and tried one tablet.  Dizziness, wobbly, weakness, malaise.  



Does it treat constipation, yes.  But it is a guanylate cyclase agonist , so, of course, it has systemic effects.  



When are too many side effects too much to even put a drug on the market?"