Depression
"I&#039;ve been on Deplin for 20 days now, along with Zoloft.  I had great success with Cymbalta, but it messed badly with my blood pressure (going from 112/65 to 175/100) so I had to go off it.  I was put on Zoloft as a stop gap, but have tried it in the past without much success, as with all the others.  They say it can take 4-6 weeks before Deplin has its full effect.  I&#039;m still hopeful, but I do so wish I&#039;d seen the overnight change like others. "