Pain
"The first time I used Lyrica I experienced an amazingly profound reaction; layers of depression and anxiety that had built up over several years melted away within minutes.  That was years ago and I have since both weaned myself off the drug and restarted taking it again.  One thing I rarely see mentioned is the terrifyingly bad withdrawal effect- missing more than one dose for me throws me into the absolute darkest pits of despair.  Has anyone else experienced this?  When I went off the drug the first time I felt like I had performed a miracle; so strong was the feeling that it took a long time for me to convince myself that things were bad enough to warrant going back on.  It still helps, but nothing as miraculous as the first time."