Nausea/Vomiting
"Promethazine has worked wonders for me on many occasions when suffering from moderate to severe nausea. Due to the somewhat intense sedation at higher doses, I usually opt for Zofran (ondansetron) for mild nausea associated with the onset of a mild migraine. That being said, promethazine is the better option if you are already severely nauseous or vomiting. If taking it for the first time, be wary of doing anything that could be dangerous while being impaired, as it is notorious for being very sedating. Also, from personal experience, I learned that I cannot tolerate this medication IV. It was given to me as an opiate adjunct and caused me to become aggressive, disoriented, and extremely restless. Overall, I still recommend it."