Pain
"I have been on Duragesic Patches for the past 12 years and they work well for me.  Because I have been on them so long my dose is high and they are very expensive but thankfully we have insurance.  If you take the brand name Duragesic Patches you can call the company and have overlay patches sent free, that help keep the patches on much better. I change my patches every two days. It is a very expensive medicine but definitely a live saver."