Bipolar Disorde
"So far so good. I have been on Remeron (30 mg) for 3 years.  It stopped being effective almost a year ago. Since then I have tried many other things. Finally my doctor suggested Seroquel (100 mg at bedtime), in addition to the Remeron. I noticed the difference almost immediately -- within 24 hours. Severe depression symptoms have eased off and also less anxiety. Unlike others, I have had no grogginess with it so far. So, while its early in the game, Seroquel looks to be good so far. Will post update as my treatment time continues."