Constipation, Chronic
"You have to find what works best for you with Linzess and when you do, you will LOVE this drug.  I&#039;ve had irritable bowel with severe constipation for all my adult life.  My insurance does not cover this drug yet I am willing to pay for it.  I have lost weight and no longer feel bloated all the time.  Before Linzess, Miralax was the only thing that even barely worked (after a few days).  Another commenter is right, if you take it more than 1/2 hour before eating (I wake up and take it in the wee hours of the morning or as soon as I wake up.)  The earlier you take it, the more the bowel movement will contain a lot of water as well.  A cup of coffee in the morning can jumpstart it."