Pain
"I recently received an injection of nalbuphine in a walk-in/non-life threatening ER for a cluster headache that had spiked to a 10 on the pain scale and it was an absolute revelation to me. With negligible side effects, it worked as well (10 to 6 on pain scale) as 4 times the typical IV injection of Dilaudid (so 4mg or about 16-24mg oral/60-80mg of oral morphine/100-150mcg of transdermal fentanyl/150-200mg of oral Demerol) without making me high or nod out. This was the first partial agonist (like buprenorphine) that actually helped severe pain. "