Constipation
"I used to have to use an enema 2-3 times a week, but now I take 145 microgram capsule with hot coffee in the morning. After about an hour, this usually results in several trips to the toilet. But (no pun intended), once I&#039;m done, I&#039;m done! Waiting for the BMs to finish is a pain in the bottom, but overall it works for better for me."