Pain
"This is an anti inflammatory.  If you have a serious inflammatory response in your system, this will take time to reduce your pain. It is not like oral pain relievers with near immediate results. Patience is needed. If you&#039;re having trouble with it adhering to the skin, make sure the area is free from oils, either naturally or lotions or soap residue. I have no problems at all with them. My RA flared up in addition to my cocyx broken off, literally.  The pain  was so severe that oral meds weren&#039;t effective. It took several days to feel the beginning of relief, and I&#039;ve improved steadily. If you&#039;ve used these short term and are the impatient type, chill out and give them a chance. They do work."