Diabetes, Type 2
"I have taken Glipizide and Glipizide XL in conjunction with metformin for a number of years with no side effects.  Anyone taking Glipizide (not XL) should be aware that blood sugar levels can plummet quickly and that dosage timing may need to be readjusted.  With Glipizide XL, I have not experienced these fluctuations; however, the positive control appears to take effect much slower as this is a time-released form."