Pain
"I think Opana ER is a GREAT pain medication. On a 1-10 pain scale, I went from a 6 with the MS-Contin to a 3 with the Opana.  I get more done around the house (I can prep, cook, and clean, as I could only do 1 of those things continuously with the MS-Contin) so it does its job in that respect, but it has never lasted 12 hours. It seems to wear off in 8 hours on the dot.  And when it wears off, you don&#039;t just hurt, you feel like total crap.  Usually you don&#039;t feel like that as soon as a pain medication wears off but with this, you do.  If I get my dosage raised to 3 instead of 2 a day so I don&#039;t have to go through the yucky stage, I can&#039;t help but wonder how I&#039;m going to feel when I come off as I have only been on it for a month."