Major Depressive Disorde
"For me, this medication did not work on a lower dose of 50 mg, 100 mg, or even 150 mg. My depression got better once I was increased to 200 mg, which is the therapeutic limit, but this may be because my depression was incredibly severe -extremely suicidal, and not functioning at all. 



However, after taking this medication for a little over a year, I have come to the realization that it no longer is working for me, and I am experiencing what my psychiatrist calls a &quot;poop out,&quot; which is apparently something most SSRIs can do. I would recommend Zoloft (Sertraline) to anyone who has depression. It has honestly been the best medication for me, but for now, I need to try something new."