Acne
"I am 38 y/o female and started spironolactone about a month after coming off of 7 months of accutane.  Accutane cleared my skin while on it, but within a couple weeks of stopping, out comes my cystic acne.   My Derm prescribed Spiro and within 1 week of starting at 25mg p/d I experienced sore stiff joints from my finger joints to my knees, extreme fatigue, and weight gain.  I lasted three weeks before the 4lbs. gained went any higher and the joint stiffness got to the point where exercising  started to become painful.   The extreme dryness especially the constant dry chapped lips while on Accutane now seem like a cake walk compared to the multitude of side effects from this medicine.   I will just have to get the cysts injected everytime now."