Pain
"It takes about 2 hours to start working, so it&#039;s definitely a long-acting medication.  It says it lasts for 12 hours but it only lasts 7 for me, every time, without fail.  I cannot just take the Zohydro ER but I need to take my rescue medication else be miserable for 2 hours before it works.



It gives you constipation sometimes, even if you drink a ton of water.



It seems to be weak pain relief.  I wish it could work better and last longer.   My doctor is switching me to a different ER pain medication now."