"I have had injections for a severe lower back injury and have tried many different pain meds. Nothing helped me until My Dr. prescribed Duexis. This medication has given me my life back! I do think it might make me retain a little fluid and I maybe gained a few  pounds but nothing significant. Also causes some gas. Nothing severe though! My pain level went from  a 9/10 to a 2/3 sometimes even a 1 on this medicine!"