Constipation, Chronic
"I tried a sample of Linzess 154mg for chronic constipation/ tortuous colon/ IBS-C

I was told it might take 4 days to work. I took it 1 hour before breakfast and 2-3 hours later I was cleaned out. It was gentle (not urgent) no cramps. However the thirst and head ache from dehydration lasted ALL day. Toward the end of the day I couldn&#039;t get enough water and I couldn&#039;t physically drink anymore water. Living in hot humid weather did not help. I wish the dose was smaller. 

I can deal with a little bit of thirst but I could not stay hydrated on this medication and it did not improve my quality of life. I may try taking in the early evening so I can sleep through the 8 hours of dehydration and see if that is tolerable but can&#039;t take this daily."