Acne
"I took spironolactone for 3 years for moderate to severe cystic acne on the lower part of my face.  I had suffered from acne to varying degrees for about 12 years and had tried most available treatments, including IBs, oral contraceptives and Roaccutane.  Some of these had temporary benefits.  With spironolactone I had a bad initial breakout in the 1st month on 100mg, then my skin cleared up almost completely over the next 2 months.  I increased to 125mg per day for about 1 year, then lowered to 100mg and only taking it 4 or 5 days per week.  I had flawless skin.  When I stopped, my acne returned after about 6 months. I have now started again, and my doctor has recommended continuing until menopause.  I am 41.  I have no serious side effects."