Irritable Bowel Syndrome
"I like Linzess and have used it off and on for 2 yrs - however dont take at night time - seems mornings work best.  I had an accident in my sleep - not pleasant and a nightmare. 

I might have to have dr lower the dosage of 290 to lower one.  I use Miralax normally - but Linzess for the times Miralax is lax on the job."