Pain
"Currently taking 2 x 10mg ER and up to 4 x 5mg IR. Tolerance has developed quickly, what used to take the pain away only half way dulls it now. My doctor is not convinced of my pain, I have asked for more but he without coming right out and saying no has refused me increased dosage. My advice is even though Opana works well initially, you will develop tolerance rapidly and require more in order to provide pain relief. I do have several bulging discs but for some reason my doctor does not see this as cause to increase the dose, only continue the same dose that I began with about 9 months ago. Sorry for the rant but it may be something you might have not considered if I had not brought it up. From what I have gathered from independent research of Opana and Oxycodone, Opana has the greatest tolerance increase potential between the two."