Depression
"Tramadol is about the most effective drug in the world for depression - for immediate, short term relief ONLY though. During the initial dosing period, 100mg twice a day utterly obliterates any negative thinking or depression symptoms. It delivers results immediately, vs the necessary patience of waiting a few days or weeks with traditional SSRI drugs.

However, tolerance DOES build to tramadaol at a pace far more rapidly then with traditional anti-depressants. I had 2 months of solid relief from 100mg 2x daily, but by the third month this does barely made a difference and my mood continued to sink. Instead of upping my dose, I went back on Zoloft which delivers less immediate, but more consistent long term results for me."