Acne
"Accutane is not an easy drug to take, but it does work.  I was 31 and had acne since puberty.  I had large cysts and nothing worked.  I took it for four months and it completely cleared up my skin.  I did have significant dryness of my skin and had painful joints, but it was totally worth it to me.  This was in 1990 and I have not had problem with my skin since.  I would definitely recommend it for severe cases of acne.  It changed my life."