"This is my first day taking Nuvigil 200mg.  I felt jittery for the first 4 hours after taking it.  Got a pretty severe headache around that 4 hour mark.  Took some tylenol which relieved the headache and I felt great the rest of the day.  Worked a 10 hour shift in a physically demanding job and I still was able to come home and stay up a few hours before going to sleep.  I will keep posting my continued experience with this medication.  It really helped me out to get on here and see what I could expect with this medication.  Thanks to everyone. Oh yeah I take this medication to help with the fatigue caused by MS.  I was taking amantadine.  Which kept me awake but didn&#039;t help my body from feeling completely exhausted."