Acne
"Been on spironolactone for probably 2 or 3 yrs now. We have always had a love/hate relationship. Rest assured, spironolactone will work for most people when it comes to combating acne (all acne is caused by hormones to some degree) but like any other medication, spironolactone is not without side effects! Over the years I have decreased my dosage and sometimes tried to completely stop taking it due to: weight gain (yes you initially lose it but just wait!), thinning hair, depression, dehydration (I believe this side effect is worse for me due to other medicines I take with it), slower metabolism/fatigue, and evidence that this medicine was totally prematurely aging my skin!  Initially it was 25mgs 2x a day but now I just take 25mgs a day."