Depression
"I have run through the entire wringer on SSRI&#039;s, an MAOI, and an SNRI. Lexapro in combination with low dose tramadol has been the most effective duo for me. Low dose 100mg once daily tramadol, with intermittent &#039;breaks&#039; (from acclimation to the medicine) has worked well for me over the past 5-6 years in mood stability, energy, motivation, and concentration with no euphoric effects. All of these are very important in my line of work. I do think that an XR formulation might be more useful in stabilizing plasma concentrations and perhaps mitigate some issues with medicine resistance and tendencies to take higher doses (not a good idea). At any rate, use should be monitored. "