Major Depressive Disorde
"I take this drug to help combat Major Depression (had for 1.5 years).  I have also tried Paxil (made me crazier), Prozac (did nothing for me) and Effexor (worked well but the sexual side effects were worse than the depression).  I started Wellbutrin at 150mg and slowly increased to 300mg by after completely titrating off Effexor, had to increase to 450 because MD came back.  SO, here is the deal - at first this drug feels awful (realize that most anti&#039;s are like this in the beginning).  I had to stick with it for at least a month and the extreme anxiety has always normalized.   But OMG - this is the first drug that motivates me to get out of bed and face each day.  for me it helps to balance my down mood &amp; &#039;urge to isolate&#039; and sabotage my day."