Rheumatoid Arthritis
"My 86 year old mother has been on Humira for the past 2 years. She combined this treatment with methotrexate.  Towards the end of the 2nd year the effect of each Humira dose lasts less than 14 days at a time.  Going down to 10 days at a time then it completely stopped working for her.  She has an excellent doctor and we are looking at other alternatives for the moment. Possibly Orencia.  Overall Humira worked wonders while it lasted."