Depression
"I have had noticeable benefits with mood support in the years that I have been on and off of SAMe. It has helped me to be less vulnerable to depression and to better control my anxiety. I took 200 mg each morning for a few years and have now been taking 400 mg each morning for a few months now. I have not had any joint problems, but I partially attribute that to SAMe (as a preventative). I have had no side effects and my only discouraging factor was cost, as it is not covered by insurance and is expensive at many retail outlets. I found it online for a much more affordable rate and have been able to take it consistently now."