Depression
"Single administration of Vortioxetine was only partially useful for me. Not satisfactory. I would rate it 50 out of 100. Could keep my office job, but my hypersomnia with excessive daytime sleepiness and non-24 hours sleep wake problem still disturbing and &ldquo;painful&rdquo;, made me want to quit the job and rest at home.
Then a doctor started to add venlafaxine (and later on desvenlafaxine) and Imipramine 10mg, starting from 2016 August. There was signifcant and noticable improvement as dosage increase. My current dosage is : Vortioxetine 20mg + Venlafaxine 112.5mg + Desvenlafaxine 50mg + Imipramine 10mg + melatonin 3mg (This dosage was reached on 2017 May 6, and today is 2017 Aug 11)
I would rate this combination 75 out of 100."