Constipation
"I have suffered for 40 years with constipation. I was taking Amitiza but I suffered from hair loss. So my Dr suggested Linzess.  It took days to kick in and then it was out of control for at least an hour. I quickly began gaining weight, so I stopped the meds for a couple of months, dropped 8 lbs :) Well I decided to try the Linzess again to see if the weight gain was caused by something else....It was the Linzess 7 lbs in 8 days. I would rather drink mineral oil and drink Miralax instead of using this drug any more...Very Pricey."