Pain
"250mg once every 12hrs didn&#039;t do much for pain in ER formulation for me but the 50mg worked quite well as a breakthrough pain medication when combined with 2/3 my typical dosage of Oxycontin.  I found that pain relief duration at 50mg was about 4hrs.  I believe that the ER formulation starts at 100mg and higher.  I am lethargic on Nucynta ER at the 250mg 2x a day dose compared to Oxycontin 30mg 3x daily."