Pain
"I&#039;ve taken Loratab 10/500 for about 3 years for osteoarthritis in the knees and I don&#039;t know what I would do without them. I was taking them prior to my knees being replaced and still take them for hip pain. The only negative side effects I&#039;ve noted is occasional constipation, which is consistent with any narcotic. I take 3-4 every day, but I have begun to notice that they are not as effective as before. I&#039;m sure I&#039;m developing a tolerance to them also. But I would recommend them for chronic pain for anyone who can tolerate them."