Major Depressive Disorde
"MDD for over 25 years and little to no positive response to 15 or so SSRIs and SNRIs aside from a slight improvement with Escitalopram which gave me utterly vile nightmares and sexual issues so it had to go. 



Started on 5mg first month, 10mg second month and been on 20mg for the last 3 weeks. Genuine improvement in mood over the last 6 weeks or so without feeling cloudy or out of it. Zero adverse sexual side effects. Slight stomach problems this past week but it may be unrelated as also on diclofenac for a herniated disc so it may be that. Time will tell. 



For someone who has been largely considered treatment resistant, this drug has been in a different league for me and with the fewest side effects of anything taken to date."