"This medication made me SO sick that I literally could not sit still. I felt better lying down but when I sat up, I had to rock because I felt so miserable. I don&#039;t even remember if it helped with the pain. If I could give it a 0 rating, I would. The concept is brilliant but it was not for me at all. I have taken Aleve (Naproxen) alone and as long as I eat enough when I take it, I&#039;m fine. I have never taken Nexium (Esomeprazole). Maybe it was the Nexium that didn&#039;t agree with me or maybe I didn&#039;t eat enough before taking the medicine or maybe a combination of the 2. I took it when it was new on the market. I was sick for about 3 days after taking and stopping this medication."