"I was blown up in Iraq in May of 2008. I have lost all my bones inside my hand along with 2 inches of my femur. I have more than 17 screws running up and down my left leg. Majority of my nerves are severed throughout my leg and left arm. From my experience with Ms-Contin, it was great but slowly diminished. I was taking 60 mg twice a day. After a few months it lost its effectiveness. My doctor decided to go with Oxycontin and morphine instant release. 100mg of Oxycontin and 60mg of morphine sulfate immediate release. I was told you should switch every 3 months so you don&#039;t build tolerance."