"Treximet works great! I know others say it does not work after the migraine starts, but for me it does. I have chronic migraines and have to take a anti-depressant drug to control it daily. However, if I do get a migraine Treximet knocks it completely out in about 20 to 30 mins. I love this product but like most people I find it very expensive but worth it. I may try taking half a pill to see if I can make it go further."