Bipolar Disorde
"This was my second time trying saphris. Throughout my first experience,  it worked great for my severe depression,  but caused me to gain 20  pounds in a very short time frame. This increase in weight wasn&#039;t acceptable, as I battle with bulimia as well. The second time around,  a few years later,  I had high hopes for this medication,  as it had virtually wiped out my depression while on it in the past, and I was taking the precautionary measure of adding Effexor to my medication regimen to help counteract the side effect of increased hunger and weight gain. The Effexor did help with decreasing my appetite;  however the antidepressant effect was not nearly as strong for some reason.  It may have even worsened my depressive symptoms."