Nausea/Vomiting
"I&#039;ve been on promethazine for about 2 years and it is the only medicine I&#039;ve ever taken that actually works for nausea. I also take tramadol which has a bad interaction with promethazine so I only take it at night as it also makes you sleepy which could be a bad thing if you needed to take one early, but 1 25mg tab shouldn&#039;t make you too drowsy."