"When I first started taking seroquel for insomnia, it literally knocked me out. I had been taking Amitriptyline for ~ 5 months and it&#039;s sedative effects weren&#039;t working that great anymore. The difference between to 2 medications is night and day. Amitriptyline mellows mellowed me out/relaxed my mind to the point that I could fall asleep. Seroquel would knock me out to cold for 7 hours. I would wake up in the same position I had fallen asleep in. Once I adjusted to the medicine the effects weren&#039;t as severe. It&#039;s still a great medicine for insomnia as it always works."