Birth Control
"I was on depo for 5 years and just got off of it 3 months ago to try and conceive.  I had never been on any other type of BC with which I could compare it. I found it nice having no period (no planning ahead for trips, no having to buy tampons!) Though it did contribute to an unpleasant vag dryness which I could have done without. Luckily I did not gain any weight in the 5 years of depo, the only caveate being that I monitored my weight more than the average person ever would and I have always exercised and eaten healthy. With that said, however, I did find that I had to try a lot harder to maintain my weight than before depo. I did not notice any other side effects. Having been off it I noticed I am more fatigued than usual."