Depression
"I am a 63 year old man (a psychologist) who has had treatment-resistant depression for many years.  In the past ten years I also have had frequent (10-15/month) migraines--migraine and mood disorders often appear together.

I started on Deplin 7.5 mg/day along with Zoloft 50 mg./day last month.  I had been on Zoloft alone previously with no improvement.  After 3-4 weeks of no change in mood or functioning, my psychiatrist increased the Deplin to 15 mg./day and the Zoloft to 75 mg./day (not a high dose).  Within a few days, I experienced an increase in energy and sharp decrease in depressed mood--to the point where I&#039;m feeling back to what &quot;normal&quot; was decades ago.  I have been through numerous antidepressants and never experienced this."