Depression
"I have had severe depression since my teens and have been on antidepressants for many years. Fortunately I have had beneficial effects from several over the years.  The most effective treatment to date has been a combination of Wellbutrin and Cymbalta. I took that combination for ten+ years and unfortunately I recently started slipping downward, increased depression and feeling out of control.  I  was prescribed Fetzima (transitioned off Cymbalta) and completed the starter pack with the only benefit being increased energy. My Dr then increased the doseage to 80mg and have been at 80mg for two + weeks.  I have never felt (for lack of a better word) so crazy in my life! I have been so irretiable, angry, depressed and unreasonable and feeling"