Bipolar Disorde
"I&#039;ve been on DEpakote ER for about 7 years and regularly for 5 years before.   I am a rapid cycler I think.  Currently prescribed 2000mg/day (1000 in the morning and 1000 in the evening).  I notice weight gain (though could be due to less nightly manic behavior and age), some upset stomach at times, overall, I think it stabilizes me.   Caffeine does make me feel more alive when on ER.  Otherwise feel quite lethargic, apathetic, less motivated.  I tend to feel more like I am depressed when taking this medicine. Will look into combination of Anti-depressive.  "