Bipolar Disorde
"I really noticed a negative difference when comparing the XR version to the regular Seroquel.  It took longer to kick in and made me so drowsy at work that I felt like I was drunk.  I think I was taking 100-200 mg.  When I went back to regular Seroquel, 100-200 mg put me to sleep fast and made a difference in stabilizing my mood without me feeling too drowsy to function the next day."