Chronic Pain
"Very similar to MS Contin before manufacturer added a second drug-release regulating feature to the matrix. I found that every 12 hours allowed too low a trough in between doses, so my dose was divided into thirds for a  every 8 hour schedule.  I continued to work throughout the titration and stayed productive for a decade. Now I&#039;m toast.  Any steady-state pain strategy will eventually change your body chemistry for ever, so it important to exhaust  all short-acting, prn &quot;as needed&quot; strategies first.  Be honest with your Doctor, it goes a long way."