Tweedy was born in Belleville, Illinois, on August 25, 1967, the fourth child of Bob and JoAnn Tweedy (nee Werkmeister). Bob Tweedy (died Aug. 4, 2017) worked at Alton & Southern Railroad in East St. Louis while Jo Ann was a kitchen designer. Tweedy has three siblings: older brother Greg Tweedy (died in 2013), brother Steven Tweedy, and sister Debbie Voll. Tweedy's mother bought Tweedy his first guitar when he was six years old, although he did not begin to play it seriously until he was twelve.
Personal life
Tweedy has been prone to migraines throughout his entire life, forcing him to miss forty days of elementary school in one year. While he attempted to regulate his use of painkillers, he was never able to stop their use for more than five weeks. Tweedy attributes this to comorbidity with major depressive disorder and severe panic attacks. In 2004, he entered a dual diagnosis rehabilitation clinic in order to receive treatment for an addiction to prescription painkillers. Tweedy quit smoking the next year; John Stirratt claimed afterward that this significantly improved the focus of the band.  Tweedy is married to former talent agent Sue Miller. Tweedy first met Miller when he was trying to get Uncle Tupelo booked at Cubby Bear, where Miller worked. Miller opened a club in Chicago named Lounge Ax in 1989, and booked Uncle Tupelo for 16 shows over four years. Miller and Tweedy began dating in 1991 and they were married on August 9, 1995. Sue was diagnosed with cancer in 2014. In an interview with Rolling Stone, Tweedy said "she's doing great now." Tweedy also said that music is a healthy distraction in difficult times such as these. They have two sons: Spencer and Sam. Spencer was the drummer for pre-teen rock band The Blisters and a new band called Tully Monster. In 2008, Spencer joined Wilco on stage at Madison Square Garden to play drums on their song "The Late Greats," while opening for Neil Young.  Miller is Jewish, and Tweedy's oldest son had a Bar Mitzvah ceremony. During his son's ceremony, Tweedy played an acoustic version of Bob Dylan's "Forever Young."

Q: What was happening in his personal life?
A: Tweedy has been prone to migraines throughout his entire life, forcing him to miss forty days of elementary school in one year.

Q: Did he ever figure out the cause?
A: attributes this to comorbidity with major depressive disorder and severe panic attacks.

Q: Did he seek help for these issues?
A: he entered a dual diagnosis rehabilitation clinic in order to receive treatment for an addiction to prescription painkillers.

Q: Did the treatment work?
A: Tweedy quit smoking the next year; John Stirratt claimed afterward that this significantly improved the focus of the band.

Q: What did the band do next?
A: joined Wilco on stage at Madison Square Garden to play drums on their song "The Late Greats," while opening for Neil Young.

Q: Were they on a tour with Neil young?
A: Monster. In 2008, Spencer joined Wilco on stage at Madison Square Garden to play drums on their song "The Late Greats," while opening for Neil Young.

Q: What else was going on in his personal life?
A: Sue was diagnosed with cancer in 2014.
Who was Sue?
Tweedy is married to former talent agent Sue Miller.
Tweedy is married to former talent agent Sue Miller.