Making pancreatic cancer less deadly

Pancreatic cancer survival rates have been improving over the last few decades, but the statistics still make grim reading. According to the America Cancer Society, the one-year relative survival rate for all cases of pancreatic cancer is 20 per cent. Only seven per cent of people diagnosed with the disease survive for five years.

One of the reasons that pancreatic cancer is so deadly is because of a protein known as S100p which is highly expressed in other aggressive cancers too. Once this protein is activated, it signals changes that tell the cancerous cell to grow and divide very quickly, which encourages rapid growth of tumours and metastases around the body.

Scientists at the University of Hertfordshire, in collaboration with Dr Tatjana Crnogorac-Jurcevic of Barts Cancer Institute, Queen Mary University of London, have used computer modelling to design new compounds that could be used therapeutically to prevent S100P from being activated.






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