Principal Investigator

Jianwen Que, B.M., Ph.D. University of Rochester work Box 633 601 Elmwood Ave Rochester NY 14642 office: KMRB 2-9615 p (585) 273-4125 f (585) 273-1450

Signaling Events That Promote Basal Cell Hyperplasia in Eosinophilic Esophagitis (EoE)

EoE is an emerging allergic disease with a rapid increasing incidence in people of all ages. Basal cell hyperplasia is one of the prominent problems seen in EoE patients. Previous studies using animal models have shown that long-term inflammation with increased levels of IL-5, IL-13 and Eotaxins promotes the phenotypic changes of basal progenitor cells. However, the underlying mechanisms remain to be further determined. We begin to address this issue by examining molecular pathways that mediate the inflammatory signaling. Built on some of the findings we are also conducting compound screen to find drugs that prevent the pathological progression. We believe the knowledge and compounds obtained through these studies will facilitate our understanding of the pathobiology of other allergic diseases such as asthma.

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