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CNGB3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CNGB3 Antibody (N-term) AP12708a
    CNGB3 Antibody (N-term) (Cat. #AP12708a) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CNGB3 antibody detected the CNGB3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NQW8
Other Accession NP_061971.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 92167 Da
Antigen Region 26-55 aa
Additional Information
Gene ID 54714
Other Names Cyclic nucleotide-gated cation channel beta-3, Cone photoreceptor cGMP-gated channel subunit beta, Cyclic nucleotide-gated cation channel modulatory subunit, Cyclic nucleotide-gated channel beta-3, CNG channel beta-3, CNGB3
Target/Specificity This CNGB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human CNGB3.
Dilution WB~~1:1000
Protein Information
Name CNGB3
Function Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Expressed specifically in the retina.
Research Areas
Citations (0)




This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease.


Komaromy, A.M., et al. Hum. Mol. Genet. 19(13):2581-2593(2010)
Thiadens, A.A., et al. Ophthalmology 117(4):825-830(2010)
Azam, M., et al. Mol. Vis. 16, 774-781 (2010) :
Peng, C., et al. J. Biol. Chem. 278(36):34533-34540(2003)

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Cat# AP12708a
(40 western blots)
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