The predictive accuracy of iNPH diagnoses could be increased using a combination of supplemental tests for iNPH. To evaluate the dynamic state of water displacement during the cardiac cycle in idiopathic normal pressure hydrocephalus (iNPH), we determined the change in water displacement using q-space analysis of diffusion magnetic resonance image. ECG-triggered single-shot diffusion echo planar imaging was used. Water displacement was obtained from the displacement probability profile calculated by Fourier transform of the signal decay fitted as a function of the reciprocal spatial vector q. Then maximum minus minimum displacement (delta-displacement), of all cardiac phase images was calculated. We assessed the delta-displacement in white matter in patients with iNPH and atrophic ventricular dilation (atrophic VD), and in healthy volunteers (control group). Delta-displacement in iNPH was significantly higher than those in the atrophic VD and control. This shows that water molecules of the white matter in iNPH are easily fluctuated by volume loading of the cranium during the cardiac cycle, due to the decrease in intracranial compliance. There was no significant correlation between delta-displacement and displacement. The delta-displacement and the displacement do not necessarily yield the same kind of information. Delta-displacement demonstrated to obtain biophysical information about fluctuation. This analysis may be helpful in the understanding physiology and pathological condition in iNPH and the assisting in the diagnosis. 
Dynamic state of water molecular displacement of the brain during the cardiac cycle in idiopathic normal pressure hydrocephalus