Intensive insulin therapy has previously shown reduced mortality with lowering blood glucose to between 4.4 and 6.1mmol/l. However presumably due to fear of hypoglycemia the current recommended glycemic target is 7.8–10mmol/l. This study evaluates the effect of modifications to the Glucosafe system on the glycemic outcomes of an in silico cohort and which modifications are necessary to lower mean blood glucose under 6.1mmol/l without hypoglycemic incidents. Based on data from 12 real patients from a previous clinical trial, 12 virtual patients were constructed, the groups were compared and results of the modifications evaluated. Results indicate that virtual patients are applicable in evaluating modifications to advice generation, and that it is possible to lower mean blood glucose below 6.1mmol/l, with no hypoglycemic incidents. In some patients increased insulin use did not achieve this and decreasing nutritional intake was necessary. 
Evaluating modifications to the Glucosafe decision support system for tight glycemic control in the ICU using virtual patients