Dual-frequency (DF) tissue harmonic imaging has been developed to take advantage of not only harmonic signal at second harmonic (2f 0) frequency but also the inter-modulation harmonic signal at fundamental (f 0) frequency for simultaneous nonlinear detection. Though phase-encoded Golay pair can improve the signal-to-noise ratio of DF harmonic signal at both f 0 and 2f 0 frequencies, conventional matched filtering cannot correctly decode the crosstalk from harmonic components at DC and third harmonic (3f 0) frequency and will lead to range side lobe artifacts in DF harmonic imaging. For orthogonal Golay pair, however, exchanging the decoding filter will output zero for the signal and keep the crosstalk the same. Therefore, the output of exchanged filtering can be subtracted from that of the original matched filtering to completely remove the spectral crosstalk. Compared to phase inversion method, the proposed orthogonal Golay decoding does not require additional transmits to cancel the unwanted DC and 3f 0 harmonic interferences and thus the achievable frame rate remains the same. Various experiments have been performed to verify the efficacy of the proposed orthogonal Golay decoding. Results from hydrophone measurements indicate that the proposed method effectively suppresses the spectral overlap between the harmonic signal and the interference. Corresponding range side lobe level (RSLL) can be suppressed by 10–20dB when the signal bandwidth is 60%. B-mode harmonic imaging also demonstrates a reduction of side lobe magnitude (SLM) by 8dB at 2f 0 frequencies. 
Orthogonal Golay excitation for range side lobe elimination in dual-frequency harmonic imaging