Context: Obesity can unfavourably alter hormonal and metabolic status via resistance to the hormone leptin, and a vicious cycle may occur in which insulin/leptin resistance and obesity aggravate one another. The vicious cycle is putatively fuelled by continuously high insulin/leptin stimulation and fat storage, as a result of high intake of strongly insulin/leptin stimulating foods and energy. Both insulin and leptin normally function as satiety signals to the hypothalamus in the brain; however, insulin/leptin resistance may reduce this signal and therefore allow continued overfeeding despite large body fat stores. In addition, reduced leptin signalling to the brain may reduce leptin's normal effect to maintain an appropriately high metabolic rate.

Question: Obesity can cause resistance to which hormone?
Answer: leptin

Question: In the so called vicious cycle, what aggravates obesity to continue the cycle?
Answer: insulin/leptin resistance

Question: A characteristic of the cycle other than fat storage is a continuously high stimulation of what?
Answer: insulin/leptin

Question: What function do insulin and leptin normally provide in the body?
Answer: satiety signals to the hypothalamus

Question: What effect does insulin/leptin resistance have on the function of insulin/leptin?
Answer: reduce this signal