Context: Mutations or deletions of clock gene in mice have demonstrated the importance of body clocks to ensure the proper timing of cellular/metabolic events; clock-mutant mice are hyperphagic and obese, and have altered glucose metabolism. In mice, deletion of the Rev-ErbA alpha clock gene facilitates diet-induced obesity and changes the balance between glucose and lipid utilization predisposing to diabetes. However, it is not clear whether there is a strong association between clock gene polymorphisms in humans and the susceptibility to develop the metabolic syndrome.

Question: What is the body clock gene in animals necessary to ensure?
Answer: cellular/metabolic events

Question: What do mice without the clock gene become?
Answer: hyperphagic and obese

Question: Beside obesity, how else does the lack of a circadian clock effect   the mice?
Answer: glucose metabolism

Question: How certain is it that these circadian clock  effects are the same in humans?
Answer: not clear

Question: What gene needs to be deleted to cause obesity in mice?
Answer: Rev-ErbA alpha clock

Question: What does thhe addition of the clock gene in mice demonstrate?
Answer: Unanswerable

Question: what happens to mice with the clock gene?
Answer: Unanswerable

Question: what facilitates nondiiet induced obesity in mice?
Answer: Unanswerable

Question: what effects are proven to be identical in mice and humans?
Answer: Unanswerable

Question: Deletion of what gene in himans causes diabetes?
Answer: Unanswerable