(CNN) -- The seeds just can't stop tumbling out of Wimbledon and on Monday it was the turn of world No.1 and five-time champion Serena Williams to experience that sinking feeling. The American crashed out of the grass court grand slam in the last-16 following a shock defeat by Germany's Sabine Lisicki -- her first reverse in 35 matches. Favorite for the title, Williams lost the opening set 6-2 before roaring back to level a pulsating contest by taking the second 6-1. But Lisicki, seeded 23rd at the tournament, produced one of the greatest performances of her career, coming from a break down to take the final set 6-4 and send shockwaves through tennis.
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Serena Williams suffers shock defeat in last-16 of Wimbledon
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Williams beaten by Germany's Sabine Lisicki in three sets
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World No.1 and five-time Wimbledon champion had been favorite for title
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Lisicki, seeded 23, reached semifinal in 2011
After the match had gone past the two-hour mark, @placeholder earned her first match point and after that went begging she made no mistake for the second to claim surely her greatest win to date.