(CNN) -- For the first time in more than 60 years, America is without a Kennedy on the national stage and it's more than just a sentimental loss to President Barack Obama. The coffin of Senator Edward Kennedy is carried by an honor guard. The last of the Kennedy brothers, Senator Edward Kennedy, died this week of brain cancer at age 77. "We shouldn't underplay the adverse effect this has on the president's healthcare fight," said Democratic strategist James Carville. Kennedy was the youngest of four brothers, the only one who died peacefully. John F. Kennedy, was elected to Congress in 1947, then the White House in 1960 and assassinated in 1963. Brother Robert was running for president when he assassinated in 1968. Their eldest brother, Joe, was killed years earlier in World War II.
@highlight
Edward Kennedy's death marks end of a dynasty in American political life
@highlight
Kennedy was among first to endorse Barack Obama's presidential campaign
@highlight
Kennedy was also key ally for Obama on his plans for healthcare reform
@highlight
Obama will miss his respected voice, negotiating skills in the Senate
@placeholder persevered and went on to a 47-year career as a prominent and productive member of the Senate.
His early endorsement of @placeholder helped Obama win the White House.