By Lucy Laing Last updated at 12:20 PM on 12th November 2011 Sisters Charlie-Marie and Emma-Jean Skinner have baffled doctors with their survival after they were both diagnosed with the rare tumours. Four-year-old Emma-Jean has two tumours in her heart and one in her brain, while Charlie-Marie, 15 months, has a tumour so big that doctors say they have never seen one that size before. Amazingly she is still alive and leads a normal life in Blackburn, Lancashire, because one of her heart chambers has grown bigger, to compensate for the size of the tumour. Hereditary condition: Emma-Jean (back) and Charlie-Marie (front) Skinner both suffer from Tuberous Sclerosis - a disorder which causes the tumours to grow
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Charlie-Marie, 15 months, was diagnosed with the tumour before she was born
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Emma-Jean, four, has two tumours in her heart and one in her brain
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The sisters have the hereditary condition Tuberous Sclerosis - which causes tumours to grow
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The parents have four other children who have not been diagnosed with the condition
Mrs Skinner said: ‘They are both developing normally at the moment and the doctors can’t believe how well @placeholder is doing as her tumour is so big.