Context: Death from laughter is a rare form of death, usually resulting from cardiac arrest or asphyxiation, caused by a fit of laughter. Instances of death by laughter have been recorded from the times of ancient Greece to the modern day.
 Question: can you have a heart attack from laughing Context: It is derived from the 19th-century Irish ballad ``The Wexford Girl'', itself derived from the earlier English ballad ``The Bloody Miller or Hanged I Shall Be'' about a murder in 1683 at Hogstow Mill 12 miles south of Shrewsbury. This ballad was collected by Samuel Pepys who wrote about the murder of Anne Nichols by the Mill's apprentice Francis Cooper. Other versions are known as the ``Waxweed Girl'', ``The Wexford Murder''. These are in turn derived from Elizabethan era poem or broadside ballad, ``The Cruel Miller''.
 Question: was the song knoxville girl based on a true story Context: Whisky a Go Go is a nightclub in West Hollywood, California. It is located at 8901 Sunset Boulevard on the Sunset Strip. The club has been the launching pad for bands including Iggy And The Stooges, The Doors, No Doubt, System of a Down, The Byrds, Buffalo Springfield, Steppenwolf, Van Halen, Johnny Rivers, Guns N' Roses, Linkin Park, and Mötley Crüe. In 2006, the venue was inducted into the Rock and Roll Hall of Fame.
 Question: is the whiskey a go go still open Context: The main function of the blood--brain barrier is to protect the brain and keep it isolated from harmful toxins that are potentially in the blood stream. It accomplishes this because of its structure, as is usual in the body that structure defines its function. The tight junctions between the endothelial cells prevent large molecules as well as many ions from passing between the junction spaces. This forces molecules to go through the endothelial cells in order to enter the brain tissue, meaning that they must pass through the cell membranes of the endothelial cells. Because of this, the only molecules that are easily able to transverse the blood--brain barrier are ones that are very lipid-soluble. These are not the only molecules that can transverse the blood--brain barrier; glucose, oxygen and carbon dioxide are not lipid-soluble but are actively transported across the barrier, to support normal cellular function of the brain. The fact that molecules have to fully transverse the endothelial cells makes them a perfect barricade to unspecified particles from entering the brain, working to protect the brain at all costs. Also, because most molecules are transported across the barrier, it does a very effective job of maintaining homeostasis for the most vital organ of the human body.
 Question: can lipid soluble drugs cross blood brain barrier
Yes
Yes
Yes
Yes