Surface Modification of Microelectrode for Deep Brain Stimulation
To improve the biocompatibility of micro-electrode for deep brain stimulation(DBS), and to reduce the immune response of brain tissue and thick encapsulation layer surround the electrode, a surface modification was executed on the polyurethane of DBS electrode head.The electrode surface firstly was modified by N_2/H_2 plasma treatments to achieve the active amino group, and then the polypeptide molecule YIGSR was endowed by a polymerization with the amino group on the electrode surface,consequently,the electrode surface had a layer of polypeptide molecule promoting nerve cell growth.The experiment results of modified electrode implant in rat brain confirm that to a certain degree,the modified electrode can reduce the thick encapsulation layer surround the electrode,it is beneficial for contact between electrode and never cells,and the electrode can make a bigger volume of tissue activated.The grafting large-molecule polymer on the polyurethane surface is feasible,and the conclusion gets referable for the further research on bioelectrode surface modification.