Myocardial performance index and aortic distensibility in patients with different left ventricle geometry in newly diagnosed essential hypertension
Background: Abnormal left ventricular (LV) geometric patterns, particularly concentric LV hypertrophy, are associated with a greater risk of hypertensive complications. The aim of this study was to investigate the association between LV myocardial performance index (LVMPI) and aortic distensibility (AD) with different LV geometric patterns in patients with newly diagnosed hypertension (HT).

Methods: We studied 181 patients with newly diagnosed HT (mean age; 51.7±5.4 years) and 39 healthy control subjects (mean age; 51.2±5.1 years). Echocardiographic examination was performed in all subjects. Four different geometric patterns were determined in hypertensive patients according to LV mass index (LVMI) and relative wall thickness (RWT). AD was calculated from the echocardiographically derived ascending aorta diameters and hemodynamic pressure measurements. LVMPI was calculated from the tissue Doppler derived ejection time, isovolumic contraction, and relaxation times.

Results: The highest LVMPI and the lowest AD values were observed in concentric hypertrophy group compared with control, normal geometry, concentric remodelling and eccentric hypertrophy groups (p<0.05, for all). LVMPI was associated with LVMI (r=0.497, p<0.001), RWT (r=0.270, p<0.001), AD (r=-0.316, p<0.001) and E deceleration time (r=0.171, p=0.02) in bivariate analysis. In multiple linear regression analysis, LVMPI was independently related to LVMI (β=0.381, p<0.001) and AD (β=-0.263, p=0.001).

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Table 1. Comparisons of echocardiographic characteristics among the groups





Conclusions: The LVMPI was highest and AD was lowest in patients with concentric hypertrophy. The LVMPI was independently associated with LVMI and AD in hypertensive patients.