GENETICALLY ENGINEERED HUMAN PITUITARY CORTICOTROPH TUMOR ORGANOIDS EXHIBIT DIVERGENT RESPONSES TO SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS
Provided herein is a method for determining selectively increasing the expression levels of SSTR5 in pituitary tumor cells in a patient, the method comprising administering to the patient a glucocorticoid receptor modulator (GRM) to the patient, wherein the GRM is capable of selectively stimulating the expression of SSTR5. Also provided are methods of inducing apoptosis in pituitary tumor cells or treating a pituitary tumor in a patient without resulting in significantly increasing the level of ACTH and methods of detecting a pituitary tumor by administering the GRM.