PERBEDAAN KADAR NITRIC OXIDEDAN DERAJAT STENOSIS PADA PENDERITAPENYAKIT JANTUNG KORONERDENGAN DAN TANPA DIABETES MELITUSDIFFERENCE OF NITRIC OXIDE CONCENTRATIONAND STENOSIS DEGREE IN CONGESTIVE HEART FAILUREPATIENT WITH AND WITHOUT DIABETES MELLITUS
ABSTRACT
Background. Coronary Heart Disease (CHD) is a disease that was caused by total or
partial stenosis from one or more coronary vessel. Endothelial dysfungtion is the first
sign of atherosclerosis that caused of CHD. Endothelial disfungtion marked by
decreasing of production or and releasing Nitric Oxide (NO.) Role NO as mediator
neurotransmision endothel and stimulated coroner dilatation. Diabet Mellitus (DM) is
the one of main risk factor CHD. There was a few of study about difference NO
concentration and stenosis degree on CHD patient with Diabet Mellitus .
Objective : To analize the difference between nitric oxide concentration and degree of
stenosis on CHD patients with and without DM.
Material and method : Cross sectional approach, 40 specimen from CHD patient with
DM and without DM who had coronary angiography. Measuring concentration NO,
stenosis degree, stenosis length, and vessel number. NO concentration was measured
quantitatively with colorimetric method. Statistical analysis difference test with non
parametric test Mann whitney.
Result : Mean NO concentration CHD patient with DM was lower than CHD patient
without DM (296.8 and 343.7 µg/ml with p = 0.141). Stenosis degree of CHD patient
with DM was worse than CHD patient without DM with p = 0.018.
Conclusions : Mean NO concentration CHD patient with DM was not different to
CHD without DM and stenosis degree of CHD patient with DM was worse than CHD
without DM significantly.
Key words : Nitric Oxide, DM, CHD, degree of stenosis
ABSTRAK
Latar belakang. Penyakit jantung koroner (PJK) merupakan penyakit akibat stenosis
pada pembuluh darah koroner . Stenosis arteri koroner terjadi akibat aterosklerosis
dengan petanda dini berupa disfungsi endotel. Disfungsi endotel ditandai dengan
pengurangan sintesis dan pelepasan Nitric Oxide (NO). Peran NO pada penderita PJK
sebagai mediator neurotransmisi sel endotel dan merangsang dilatasi koroner.
Diabetes melitus (DM) merupakan salah satu faktor risiko utama PJK. Saat ini
penelitian tentang perbedaan kadar NO dan derajat stenosis pada penderita PJK dengan
DM belum banyak dilakukan.
Tujuan : Mengetahui perbedaan kadar NO dan derajat stenosis penderita PJK dengan
dan tanpa DM
Material dan metode: Pendekatan belah lintang. 40 spesimen penderita PJK dengan
DM dan tanpa DM yang menjalani angiografi koroner. Dilakukan pemeriksaan kadar
NO, derajat stenosis, panjang stenosis, dan jumlah vessel. Kadar NO diukur secara
kuantitatif menggunakan metode kolorimetrik. Analisis statistik uji beda non
parametrik dengan Mann Whitney.
Hasil : rerata kadar NO penderita PJK dengan DM lebih rendah dari penderita PJK
tanpa DM. (296,8 dan 343,7 µg/ml dengan p=0,414. Derajat stenosis penderita PJK
dengan DM lebih berat dibandingkan penderita PJK tanpa DM dengan p = 0,018.
Kesimpulan : Rerata kadar NO penderita PJK dengan DM tidak berbeda dibandingkan
penderita PJK tanpa DM dan derajat stenosis penderita PJK dengan DM lebih berat
secara bermakna dibandingkan penderita PJK tanpa DM.
Kata kunci : Nitric oxide, DM, penyakit jantung koroner, angiografi koroner.