F-025 * PROGNOSTIC FACTORS IN PULMONARY CARCINOID CAUSING CUSHING'S SYNDROME: A MULTICENTRE ANALYSIS
respectively. All patients but 2 (treated with chemotherapy) underwent surgi- cal resection with curative intent. At diagnosis, 8 patients (40%) presented with advanced (or locally advanced) disease. The overall median and 5-year survivals were 47 months and 71.5%, respectively. A complete remission of CS was obtained in 14 cases (70%). Four patients (25%) experienced a relapse of disease after radical surgery. Log-rank analysis identified the tumour location (peripheral versus central; P = 0.004), the histology (atypical versus typical carcinoids; P= 0.064), the pTNM-staging (P = 0.020), the number of mitosis (P= 0.001), the ki-67% index (P= 0.001) and the persistence of CS (P= 0.035) as prognostic factors in such cohort of patients. Conclusions: Pulmonary carcinoids causing Cushing's syndrome are character- ized by a high rate of lymph nodal involvement at diagnosis (N2 disease in 30% of patients), a suboptimal prognosis (5-year survival = 71.5%) and a remarkable risk of relapse (25%) even after radical resection. Tumour location (periph- eral location), histology (atypical carcinoids), high number of mitosis, high ki-67% index, advanced p-Stage and the persisting of the CS after surgery cor- relate with a poor prognosis in such patients. Disclosure: No significant relationships.