AMINOTETRAHYDROPTERIDINES AND PROCESSES FOR THE MANUFACTURE THEREOF
The present invention relates to aminotetrahydropteridines and processes for the manufacture thereof. In particular, the present invention relates to a process for the manufacture of aminotetrahydrobiopterine. Said compound is an inhibitor of NO-synthase and may therefor be a valuable agent in medical applications. The manufacturing process starts from D-ribose, which is transformed in several reac­tion steps into an open chain osone structure with protected hydroxyl groups. Pre­ferred protective groups are ether forming groups, in particular benzyl groups. Subsequent reaction with tetraaminopyrimidine yields hydroxyl-protected ami­nopteridines, which, after reduction to aminotetrahydropteridines and cleavage of the protective groups, yield the target compound. The invention also relates to said intermediates and a process for the manufacture thereof. Another Subject matter of the present invention is the use of D-ribose in said manufacturing proc­esses.