INVASIVE DUCTAL CARCINOMA AGGRESSIVENESS CLASSIFICATION
The present invention relates to methods of classifying subjects with Invasive Ductal Carcinoma (IDC), a type of breast cancer, into low genetic grade (LGG) or high genetic grade (HGG), categorized by an optimal composition of genetic features. In particular, a group of 22 signature genes consisting of CENPA, CENPN, FAM72A/ FAM72B/ FAM72C/ FAM72D, CAPN8, NAT1, NOSTRIN, MELK, CDCA8, MYBL2, CDC45, BUB1, KIF2C, UBE2C, ORC6, KIF14, KIF13B, SHCBP1, PIF1, CDCA5, MCM10, MTFR2 and TICRR is used in the classification. The present invention also provides a prognostic evaluation based on the selected features providing a quantitative personalized predictor of the disease outcome, facilitating therapeutic regime based on the diagnostic results. Also encompassed are kit and assays comprising probes/primers of said genes.