CREATINE AMIDES, A METHOD FOR THE PRODUCTION THEREOF AND AN AGENT EXHIBITING A NEUROPROTECTIVE ACTION
The invention relates to pharmaceutical chemistry, in particular to new biologically active substances (BAS) and to the properties thereof, namely, to creatine derivatives of general formula : NH=C(NH2)-N(CH3)- CH2-CO-NH-R?X, wherein R is an amino-acid residue or a substituted amino-acid residue; X is a low-molecular organic or mineral acid or water. The new substances are produced by interacting guanidyl agents with sarcosine amides in polar organic solvents at a temperature equal to or less than 50°C. The new substances exhibit a neuroprotective action and can be used in the form of an agent promising for preventing and treating brain ischemia.