METHOD FOR THE STEREOSELECTIVE PREPARATION OF A DERIVATIVE OF beta -PHENYLISOSERINE AND ITS USE IN THE PREPARATION OF TAXANE DERIVATIVES
Method of stereoselective preparation of a derivative of (beta)-phenylisoserine of formula (I) by the action of an N-carbonylbenzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), followed by hydrolysis of the product obtained. In formulae (I), (II) or (III), R is an optionally substituted phenyl radical or R1-O, Ar is an optionally substituted aryl radical and G1 is a hydroxy function protection grouping. The product of formula (I) is particularly useful in preparing taxol and Taxotere which have remarkable antitumor properties.