NOVEL AMINO ACID DERIVATIVES, METHOD FOR PREPARING SAME, AND THERAPEUTIC USE THEREOF
The invention relates to novel compounds of the formula (I) R1NH-CH(R2)-CH2-S- S-CH2-C(R3)(R4)-CONH-C(R5)(R6)-COOR7, in which R1 is a (acyloxy)alkyl carbamate -C(O)-O-C(R8)(R9)-OC(O)-R10 group; R2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle; R4 is a hydrogen atom and R3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R3 and R4 form together a saturated cycle; R5 and R6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R5 and R6 form together a saturated cycle; R7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR12(R13)C(O)OR14 or OCR12(R13)OC(O)R14 or OCR12(R13)OC(O)OR14. The invention also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier. The invention further relates to the combined use of at least one cannabinoid derivative and/or morphine or one derivative thereof and/or Gaba derivatives for enhancing the analgesic and anti-depressive effect of the novel compounds of the formula (I).