Correlation between ERβ gene polymorphism and breast cancer of Uyghur nationality and Han nationality in Xinjiang area
OBJECTIVE Estrogen receptorβgene(ERβ)has two common polymorphism locis,which is a subtype of estrogen receptor(ER),different individual expression level and function of ERβmay be affected by the ERβgene polymorphism.The objective of this study is to investigate the relationship of ERβRsaⅠ polymorphism with susceptibility to breast cancer in patients of Uyghur and Han.METHODS A total of 493 women including 130 Uyghur cases,125 Uyghur controls,120 Han cases and 118 Han controls were enrolled to determine the Rsa Ⅰ polymorphism of ERβusing PCR-RFLP method.Then the relationship of ERβRsa Ⅰ polymorphism with breast cancer susceptibility was analyzed.RESULTS Significant differences of ERβRsaⅠ genotypes and allele frequencies were observed between cases and controls in whole group(P0.05).However,in Uyghur group,there were no significant differences of ERβRsaⅠ polymorphism between cases and controls(P0.05).While,in Han group,our finding showed significant differences of ERβRsaⅠ polymorphism between cases and controls(P0.05).We also found that compared with those carrying rr genotype,the population carrying Rr genotype without fertility or benign breast diseases showed decreased risk of breast cancer in Han group(OR=0.466,95%CI was 0.234-0.928,P0.05;OR=0.421,95%CI was 0.204-0.869,P0.05).CONCLUSIONS Our data shows significant difference of ERβRsa Ⅰ polymorphism between cases and controls in Uyghur and Han groups.People of Han carrying Rr genotype may have a decreased risk of breast cancer in Xinjiang.