USE OF CIRCULATING MICROPARTICLES TO STRATIFY RISK OF SPONTANEOUS PRETERM BIRTH
The present disclosure relates to proteomic biomarkers of spontaneous preterm birth, proteomic biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides tools for determining whether a pregnant subject is at an increased risk for premature delivery, as well as tools for decreasing a pregnant subjects risk for premature delivery. In particular embodiments, highly predictive tests are provided for the detection of spontaneous preterm birth during the first trimester of gestation, in nulliparous pregnant subjects; and other highly predictive tests are provided for detection of spontaneous preterm birth during the first trimester of gestation in pregnant subjects, regardless of parity.