Comparison of effects of Rosuvastatin and Atorvastatin on blood lipid,serum high-sensitivity C reactive protein and carotid atherosclerotic plaques in patients with acute cerebral infarction
Objective To Compared the effect of Rosuvastatin and Atorvastatin on blood lipid,serum highsensitivity C reactive protein( hs-CRP) and carotid atherosclerotic plaques in patients with acute cerebral infarction( ACI). Methods Based on the standard therapy of cerebral ischemic stroke,Rosuvastatin group was treated with Rosuvastatin tablets 10 mg / d,Atorvastatin group was treated with Atorvastatin tablets 20 mg / d,lasting for 6 months.The levels of blood lipid and hs-CRP were detected,and atherosclerotic plaque were observed by carotid ultrasound before treatment and 6 month after treatment. Results Compared with pretreatment,the levels of total cholesterol( TC),triglycerides( TG),low density lipoprotein cholesterol( LDL-C),hs-CRP in Rosuvastatin group and Atorvastatin group were significantly decreased( all P 0. 05). At 6th month after treatment,the levels of TC,TG and LDL-C and hs-CRP in Rosuvastatin group were significantly decreased than those in Atorvastatin group and control group( all P 0. 05). There was no statistical significance of intima-media thickness( IMT) in the 3 groups before treatment. Compared with pretreatment and control group, IMT and the rate of hypoechoic plaque in Rosuvastatin group and Atorvastatin group at 6th month after treatment were significantly decreased,and the rate of hyperechoic plaque were significantly increased( all P 0. 05). At 6th month after treatment,the NIHSS and mRS scores in Rosuvastatin group, Atorvastatin group and control group were significantly decreased than that in pretreatment( all P 0. 05). There was no statistical significance of NIHSS and mRS scores in the 3 groups before treatment and 6 month after treatment. Conclusions Rosuvastatin and Atorvastatin can reduce the levels of blood lipid and hs-CRP in ACI patients,and inhibiting the atheromatous plaque formation. Rosuvastatin has stronger effect than Atorvastatin.