ATTENUATED MICROORGANISMS FOR THE TREATMENT OF INFECTION
A <i>Salmonella</i> microorganism has an attenuating mutation which disrupts the expression of an apparatus gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response.