Clinical analysis of causes of pregnant thrombocytopenia and outcomes of pregnancy
Objective To investigate the causes of pregnant thrombocytopenia,and to find optimal treatment for better outcomes of pregnancy. Methods Forty-nine cases of thrombocytopenia in pregnancy were collected from year 2000 to 2008.The causes as well as treatment methods of thrombocytopenia and outcomes of pregnancy were analyzed retrospectively. Results Patients of thrombocy topenia in pregnancy were mainly caused by pregnancy-associated thrombocytopenia(PAT)(21,42.86%),followed by idiopathic thrombocytopenia(13,26.53%),pregnancy induced hypertension(7,14.29%),systematic lupus erythematosus(2,4.08%),intrahepatic cholestasis of pregnancy(2,4.08%),as well as unknown causes(4,8.16%).Twenty-seven patients completed their pregnancies by cesarean section and other 22 cases did by vaginal delivery.There was 1 case with postpartum hemorrhage(2.04%).Unfortunately,2 patients had dead fetus and the other four patients gave newborns with blood platelet counts lower than normal range. Conclusion Thrombocytopenia in pregnancy may result from many causes and PAT is the most common observed reason.Glucocorticoid and other platelet related therapies are helpful in treatment for the situation.Many patients with thrombocytopenia can deliver by vagina if fresh blood or platelet is supplied promptly to make the blood platelets above 50×109/L.