DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK1)
The invention provides a human ROCK1 which is associated with cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of ROCK1 as well as pharmaceutical compositions comprising such compounds.