NMR Crystallography as the state-of-art tool for insight into structural properties of active pharmaceutical ingredients and their formulations – Innovative methodology to improve the quality of medical products.
The aim of this project is to develop methodology of analysis active pharmaceutical ingredients (APIs) and their formulation to precisely describe structural behaviours existing in their solid-state forms. The extensive study will consider NMR Crystallography as the perfect tool for solving problems of polymorphism, solvatomorphism and/or effect of co-crystallisation. For selected investigating objects, attempt will be made also to answer the question of influence of excipients and manufacturing procedure on API. Since the neurodegeneration and collaborative diseases became one of the main problems for the elderly people, this work will focus on the medicines designed in the last decade for treatment of that diseases, such as Parkinson, Sclerosis Multiplex, Schizophrenia or Dementia. Finally, our study not only allows to get important structural information for particular objects but also promises to extend capability of innovative methodology to improve the quality of medical products.