Integrated approach for environmentally benign c-c coupling reactions
Pharmaceutical industry needs environmentally cleaner processes. One of the most important family of chemical reaction is the formation of carbon-carbon bond by Pd mediated C-C coupling. It is estimated, that more than 50% of new drug synthesis will include at least one C-C coupling reactions. However, there are several issues regarding this reaction related to high environmental impact, complicated processes due to air-sensitive catalyst, post-processing, solvent issues, and catalyst recovery. We have developed a new integrated approach for carrying out C-C coupling reactions in an environmental benign and cost-effective way. Our CC-Coupler method targets to overcome all the issues regarding the reaction. Our aim is to commercialise the CC-Coupler as an integrated technology, providing an air-stable, highly performant catalyst with an adequate flow-chemistry device and parameter set optimised for the clients’ needs. In this Phase 1 project, as a first step, we shall carry out a feasibility assessment. The success of this project will promote the growth of our company and make a step towards cleaner pharmaceutical industry.