REGULATABLE RETROVIRUS SYSTEM FOR GENETIC MODIFICATION OF CELLS
A novel regulatable retroviral vector in which the v-myc oncogene is driven by a tetracycline-controlled transactivator and a human cytomegalovirus minimal promoter fused to tet operator sequence useful for immortalization of adult neuronal progenitor cells is provided. Producer cell lines which produce high titers of the recombinant retrovirus are also provided.