Data Mining of the Regularity of Compound Herbal Formulae for Gastroesophageal Reflux Disease
Objective To study the regularity of compound herbal formulae for gastroesophageal reflux disease.Methods Compound herbal formulae published on journals in CBMdisc(1978.1-2010.11),Wanfang Data(1998.1-2010.11) and CHKD(2004.1-2010.11) for the treatment of gastroesophageal reflux disease were analyzed by using association rule,frequency analysis and cluster analysis.Regularity of key herbs and pair herbs was summarized.Results There were 119 prescriptions(totaling 144 herbs and 1 206 counts of frequency) in the compound herbal formulae for gastroesophageal reflux disease.The herbs which were used for more than 10 times included 31 herbs(totaling 913 counts of frequency).They were cluster analyzed and classified into 6 clusters including descending qi,strengthening spleen,clearing heat,soothing liver,promoting blood circulation for relieving pain and inhibiting acidity drugs.Eighteen herbal pairs were obtained by association rule analysis,mainly for herbs of descending qi combined with soothing liver,clearing heat and strengthening spleen.Conclusions It was feasible that study the regularity of Chinese compound prescription for the treatment of gastroesophageal reflux disease by data mining.