1-HYDROXY-1-((4'-HYDROXY-3'AMINOSULFONAMIDO)-PHENYL)-2-AMINO-ETHANES AND SALTS
Procedure for the preparation of sulfa drugs **(See formula)** wherein R1 signifies a hydrogen atom, a lower alcohol radical or, together with R2, a tetramethylene or pentamethylene radical; R2 signifies a lower alcohol radical or, together with R1, a tetramethylene or pentamethylene radical; R3 signifies hydrogen or the hydromy group; R4 represents hydrogen, the methyl or ethyl group; R5 means hydrogen, a branched or straight-chain alcohol radical, which may also be substituted by a heterocyclic radical, or an aralkoxy or aryloxyalkyl radical, in which the aryl group may also be substituted, in the form of racemates, optionally in pairs of diastereoisomeric antipodes, and of the optical antipodes as well as of the corresponding acid addition salts, for the preparation of the compounds according to the invention, in which R3 is the hydroxy group, ketones of the formula are reduced **(See formula)** and because, if desired, the products obtained are split into the optical antipodes or optionally into the pairs of diastereoisomeric antipodes, bases obtained primarily are transformed into salts by addition of acid, and salts by addition of acid obtained primarily are transformed into free bases or salts of other acids. (Machine-translation by Google Translate, not legally binding)