PROPHYLACTIC TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTION WITH AN ADENOVIRUS BASED VACCINE
Methods of inducing a protective immune response against respiratory syncytial virus (RSV) and methods of preventing infection and/or replication of RSV, without inducing a severe adverse event in human subjects are described. The methods include administering to the subjects an effective amount of an adenoviral vector encoding a recombinant RSV F polypeptide that is stabilized in a pre-fusion conformation.