Laboratory monitoring of neonates' infectious process
Identification of the stage of neonate9s infectious process is an urgent problem of medicine in view of absence of accurate clinical and laboratory criteria. The biochemical indicators used for dynamic laboratory monitoring of infectious process are often inconsistent and changeable. The objective of this research is dynamic (at the birth, 3-4 and 9-10 days of life) studying of proteolytic system9s indicators of blood serum (elastase and inhibitors) of neonates, against congenital pneumonia. Two groups of neonates were organized in order to achieve the objective. The second group included full-term neonates with bilateral congenital focal bacterial pneumonia, n=36. The first group included healthy full-term neonates, n=12. The statistical analysis was carried out with the use of Mann-Whitney9s criterion. The activity of blood serum9s elastase of neonates with congenital pneumonia during dynamic research was much lower on the 3d-4th days of life than on the day of birth 0.65(0.55 / 0.72) me/mkl and 0.81(0.78 / 0.88) me/mkl. During clinical recovery (10–14 day) further decrease in the activity of blood serum9s elastase – 0.51(0.43 / 0.63) me/mkl was observed. The increase in inhibitor protection was observed on the 3d-4th days of life 21.35 (19.65 / 24.35) IE/ml with a maximum on the 9th-10th days of life 24.25 (22.55 / 25.16) IE/ml. The conclusions of the research are as follows: the concentration of elastase in blood serum depends on a disease stage. During the acute period the activity of enzyme is high and it decreases gradually to recovery. The maximum inhibitor activity was observed during recovery.