A Cholesterol and Actinide Dependent Shadow Biosphere of Archaea And Viroids in Neoplastic Disorders
Background: Endogenous digoxin has been related to the pathogenesis of non-hodgkin’s lymphoma, multiple myeloma and CNS glioma. The possibility of endogenous digoxin synthesis by archaea with a mevalonate pathway and cholesterol catabolism was considered. Methods: 10 cases each of non-hodgkin’s lymphoma- diffuse large B cell type, multiple myeloma and CNS glioma- glioblastoma multiforme before starting treatment and 10 age and sex matched healthy controls from general population were chosen for the study. Cholesterol substrate was added to the plasma of the patients and the generation of cytochrome F420, free RNA, free DNA, polycyclic aromatic hydrocarbon, hydrogen peroxide, serotonin, pyruvate, ammonia, glutamate, cytochrome C, hexokinase, ATP synthase, HMG CoA redutase, digoxin and bile acids were studied. The changes with the addition of antibiotics and rutile to the patient’s plasma were also studied. Results: The parameters mentioned above were increased the patient’s plasma with addition of cholesterol substrate. The addition of antibiotics to the patient’s plasma caused a decrease in all the parameters while addition of rutile increased their levels. Conclusion: An actinide dependent shadow biosphere of archaea and viroids is described in non-hodgkin’s B cell lymphoma, multiple myeloma and CNS glioma- glioblastoma multiforme producing the Warburg phenotype contributing to their pathogenesis. Key words : Archaea; Viroids; Cholesterol; Actinide; Non-hodgkin’s lymphoma; Multiple myeloma; CNS glioma