Meta-analysis for evaluating effect of statins on albuminuria in patients with diabetes-induced renal diseases (2000-2009)
Objectives To evaluate the effect of statins on albuminuria in patients with diabetes-induced renal diseases. Methods All the papers of randomized controlled trials evaluating the effects of statins on diabetes-induced renal diseases in China and abroad were investigated. Meta-analysis was performed on the basis of the evaluation of 23 trails of randomized controlled trials (including 1 789 patients). Results The proteinuria excretion measured by 24 h urine collection was compared by random effect mode:χ2 =54.97,weight mean difference (WMD) =-0.79 [-1.51,-0.06]; Albuminuria excretion measured by 24 h urine collection in the early stage was compared by random effect model : χ2= 7251.14, WMD=-38.55 [-65.25,-11.85]; Albuminuria excretion measured by 24 h urine collection in the clinical stage was compared by fixed effect model: χ2=0.99, WMD=-70.49[-99.72,-41.27];reported adverse reactions were 44 patients. Conclusions Statins have a beneficial effect on pathological proteinuria and the albuminuria in the diabetes-induced renal diseases. The validity of this finding requires supports by more studies of larger size to evaluate the effect on endstage of the diseases.