Mucormycose rhino-cérébrale à Rhizopus oryzae : à propos d’un cas
Summary Mucormycosis infections are rare in France, and are caused by fungi of the class Zygomycetes, order Mucorales. The prognosis of these emergent pathologies remains severe. We report a case of a 44-year-old man, who has been admitted to the Emergency Care Unit, for a fly-away acute sinusitis resistant to antibiotic treatment. Biological parameters revealed a diabetic ketoacidosis. On day 2 after admission, ocular dysfunctions happened. An ethmoido-oculo-cerebral lesion was revealed by a cerebral MRI, suggesting a mucormycosis infection. Isolation of Rhizopus orizae was performed by a surgical histologic biopsy. Mucormycosis agents of are ubiquitary. Rhino-cerebral lesions are the most common clinical manifestations. Diabetic ketoacidosis and hematologic malignancies are respectively the two higher risk factors of mucormycosis development. This angioinvasive fungal infection induces more than a 50 % rate mortality despite the first surgical-line therapy. To conclude, a global therapeutic care and a complete knowledge of this varied clinical fungi infection must be controlled. The actual incidence of diabetes is increased, thus a mucormycosis infection must be evoked in non-responsive head and neck infections.