CONTROL OF RHEOLOGICAL PROPERTIES OF MIXED HYALURONATE/LUBRICIN SOLUTIONS
Disclosed are mixed solutions of PRG4 and hyaluronic acids having controlled, enhanced rheological properties adapted for various particular medical and cosmetic uses. Such solutions combine the solution-based lubrication ability of HA and the boundary -based lubricating effects of lubricin. Being more viscous, the solutions when used for joint viscosupplementation enhance both the duration of the HA within the joint capsule (in vivo halflife) and enhance the cushioning effects of the HA, as well as improve both solution and boundary mode lubrication mechanisms.