Effects of Permutations and Combinations of Ginseng and Radix Salviae Miltiorrhizae of endothelial function in myocardial infarction rat
Objective To research the effects of ginseng and salvia miltiorrhiza on the endothelial function in rat model with myocardial infarction. Methods Establish rat myocardial infarction model,divide rats into control group,model group,people participate in salvia miltiorrhiza compatibility 2 /1 group,2 /0 group,0 /1 group,drug lavage 2 weeks,respectively take venous blood centrifugal,the measurement of serum NO and ET,MDA,SOD content. Results Compared with control group,model group NO,SOD decreased,ET,MDA increased,( P 0. 05). Compared with model group,2 /1 group,2 /0 group,1 /0 group NO,SOD increased,ET,MDA were lower( P 0. 05,P 0. 01). 2 /1 group NO,ET,SOD,MDA change have significant differences( P 0.05). Conclusion Ginseng and salvia miltiorrhiza 2: 1 compatibility group can significantly improve myocardial infarction model rat vascular endothelial function,its mechanism of action may improve endothelial active material release and oxidation reaction.