Orally delivered nanoparticle drug-delivery systems for dental applications and their systemic toxicity
Abstract For many decades, the prominent thrust of pharmaceutical research has been to deliver drugs in the form of suitable drug-delivery systems or dosage forms to achieve efficient therapeutic effects. In recent years, there has been unparalleled development in pharmacotherapeutics, especially in characterizing materials at the nanoscale level and the introduction of polymers that can be used to control the delivery of the drug to a specific organ. The new areas of targeting drugs using the antibodies are gaining momentum in drug-delivery research. Nanotechnology and nanoscience are widely seen as having great potential to deliver benefits to many areas including engineering, consumer products, and health care. Concurrently, the application of nanotechnology in health care is posing new safety challenges in the human body. The regulatory bodies worldwide are critically thinking about creating regulatory pathways for the nanoparticulate drug-delivery systems. This chapter addresses various aspects of orally delivered nanostructured drug-delivery systems and their systemic toxicity.