Quinoline derivatives as antibacterial agents
QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS The present invention relates to the use of a compound for the manufacture of a medicament for the treatment of a bacterial infection, said compound being a compound of formula (R)r 7 4 (R')\ R H / R a pharmaceutically acceptable acid or base. addition salt thereof, a stereochemically isomeric form thereof or a N-oxide form thereof, wherein R' is hydrogen, halo, polyhaloCI 6alkyl, Ci-6 alkyl, Ar or Het; p is an integer equal to 1 or 2; R 2is Ci-6 alkyloxy, C1-6alkyloxyCi-6alkyloxy or CI-6alkylthio; R3 is Ar, Het or Het'; R4 and R5 each independently are hydrogen, CI-6alkyl or benzyl; or R4 and R5 together and including the N to which they are attached may form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyI, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl, pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, morpholinyl and thiomorpholinyl, each of said rings may optionally be substituted with C16alkyl, halo, polyhaloC1-6alkyl, hydroxy, hydroxyCI- 6alkyl, Ci-6alkyloxy, amino, mono- or di(CI-6alkyl)amino, CI-6alkylthio, CI-6 alkyloxyC1-6alkyl, CI. 6alkylthioC..6alkyl or pyrimidinyl; R6 is hydrogen, halo, polyhaloCI-6 alkyl, C1- 6alkyl, CI-6 alkyloxy, CI-6alkylthio; or two vicinal R6 radicals may be taken together to form a bivalent radical of formula -CH=CH-CH=CH- ; r is an integer equal to 1 or 2; R7 is hydrogen, CI-6alkyl, Ar, Het or Het'; provided that the bacterial infection is other than a Mycobacterial infection.