APPLICATION OF <13>C-<13>C, <13>C-<15>N, AND <13>C-<13>C-<15>N ISOTOPICALLY ENRICHED PROTEINS AS TISSUE-DIRECTED IMAGE-ENHANCEMENT REAGENTS FOR MAGNETIC RESONANCE IMAGING
The present invention relates to a method employing a tissue-directed <13>C, <13>C-<13>C, <13>C-<15>N or <13>C-<13>C-<15>N isotopically enriched protein reagent as a diagnostic contrasting agent in magnetic resonance imaging to enhance the contrast of a targeted site in a mammalian tissue.