IDENTIFICATION OF CELLULAR TARGETS FOR BIOLOGICALLY ACTIVE MOLECULES
A genetic screening methodology for rapid identification of candidate targets of any small molecule cellular effectors and other signals and modulators of cellular functions and pathways is provided. The effect of a small molecule or other signal on a cell is titrated by expressing within the cell cDNA that encodes a polypeptide that is the molecular target or that is responsible for directly or indirectly producing the molecular target.