PLANT-DERIVED RESISTANCE GENE
Disclosed are nucleic acid molecules encoding polypeptides which are capable of conferring resistance against, and being triggered by plant pathogens such as nematodes (e.g. Heterodera schachtii Schmidt and related isolates). In particular, nucleic acid molecules relating to the beet cyst nematode (BCN) Resistance Gene Hs1-2 are provided and embodiments thereof including specific primers, vectors, host cells, polypeptides, antibodies, aptamers, transgenic plants, methods of producing and employing these, and methods of influencing the resistance trait in a plant. Furthermore, transgenic plants are provided resistant to nematodes, in particular Heterodera schachtii because of the expression of an Hs1-2 transgene. Furthermore, screening methods for identifying and obtaining plant protective compounds are described.