11????-HSD1 INHIBITORS
The invention relates to compounds of formula (I) wherein A, Y, Z<SUP>1</SUP>,<SUP/>Z<SUP>2</SUP>,<SUP/>R<SUP>1 </SUP>to R<SUP>3 </SUP>and X<SUP>1 </SUP>to X<SUP>4 </SUP>have the meaning as cited in the description and the claims. For example A is 4'-fluorobiphen-4-yl; Y is -S(O)2NH-; R<SUP>1</SUP>, R<SUP>2 </SUP>are H; X<SUP>1</SUP>,<SUP/>X<SUP>2</SUP>,<SUP/>X<SUP>4 </SUP>are CH; X<SUP>3 </SUP>is C-F; Z' is =0; and Z<SUP>2</SUP>-R<SUP>3</SUP> is N(CH2CH3)<SUB>2 </SUB>. Said compounds are useful as 11ß-HSD1 inhibitors. The invention also relates to the preparation of such compounds as well as the production and use as medicament.