Who will benefit from uterus-sparing surgery in adenomyosis-associated subfertility?
<h3>Objective</h3> To analyze the determinants of successful pregnancy following laparoscopic adenomyomectomy. <h3>Design</h3> Retrospective cohort study. <h3>Setting</h3> A general hospital. <h3>Patient(s)</h3> A total of 102 women who had a desire for pregnancy underwent laparoscopic adenomyomectomy from 2007 to 2012. <h3>Intervention(s)</h3> Surgical excision of the uterine adenomyosis; statistical analysis for fertility outcomes. <h3>Main Outcome Measure(s)</h3> Pregnancy rates and the results of univariable and multivariable analyses. <h3>Result(s)</h3> When the women were divided into ≤39 years and ≥40 years age groups, clinical pregnancy rates were 41.3% and 3.7%, respectively. Factors associated with clinical pregnancy were: history of IVF treatments, posterior wall involvements, and age, with odds ratios of 6.22, 0.18, and 0.77, respectively. In the younger group, 60.8% of women with history of IVF failure showed successful pregnancy after surgery. We experienced 2 cases of placenta accreta in far advanced cases. <h3>Conclusion(s)</h3> This study demonstrated age as a determinant in fertility outcomes. Surgery could be a beneficial treatment for women who experienced IVF treatment failures, especially at ages of ≤39 years. We could not show a clear benefit of the surgery on fertility outcomes of the group aged ≥40 years. Extremely severe adenomyosis affecting a broad range of the uterine subendomerial myometrium should be treated carefully on a pregnancy course.