PIPERIDINE DERIVATIVES
1393979 Piperidine derivatives JOHN WYETH & BRO Ltd 10 Dec 1973 [21 Dec 1972] 59142/72 Addition to 1345872 Heading C2C Novel compounds of Formula I in which R<SP>1</SP> = H, OH, OCH 3 , F or Cl and A = -CO(CH 2 ) 3 -, -CHOH.(CH 2 ) 3 - or -O(CH 2 ) 3 -, and acid addition salts thereof, are prepared by (a) reacting 4-(cyclohexylcarbonylamino)piperidine with a compound of Formula III in which Y is a replaceable atom or group, or (b) reacting a compound of Formula IV with a cyclohexylcarbonyl acylating agent. Compounds I in which A = -CHOH.(CH 2 ) 3 - are prepared by reduction of compounds I in which A = -CO(CH 2 ) 3 -. In the single example, 4 - cyclohexanecarboxamido - 1 - (4 - phenyl- 4-oxobutyl)piperidine is prepared by acylation of 4 - amino - 1 - (4 - phenyl - 4 - oxobutyl)- piperidine, itself prepared by hydrolysis of the corresponding 4-benzamido compound. Pharmaceutical compositions having hypotensive activity, for oral or parenteral administration, comprise one of the above novel compounds together with a pharmaceutical carrier.