Abstract 13187: Abnormalities in Cardiac Strain are Found in Young Adults with Type 2 Diabetes Mellitus
Introduction: Diabetic cardiomyopathy in adults begins with diastolic dysfunction progressing to systolic dysfunction and heart failure. Tissue Doppler imaging to measure strain and strain rate may demonstrate abnormalities earlier in the process than traditional echo. We hypothesized that abnormal strain can be found in young adults with Type II Diabetes Mellitus (T2DM). Methods: Comprehensive echocardiography and speckle-tracking imaging was measured in 338 subjects (22.2 + 3.7 years, 38% male, 63% African American) stratified into lean (L=112), obese (O=121) and T2DM (T=105) groups. Anthropometrics, BP, HR, fasting lipids, glucose and CRP were collected. Echocardiograms were performed on a GE Vivid 7 machine and read with EchoPAC®software for global longitudinal (4-chamber) strain (GS) and strain rate in systole (GSRs), early diastole (GSRe) and active diastolic phase (GSRa). ANOVA was performed to compare differences among groups for CV risk factors and strain measures and ANCOVA to determine if prese...