{"content":[{"text":"American Journal of Pharmacology and Toxicology 4 (4): 118-126, 2009 \n ISSN 1557-4962 \n © 2009 Science Publications","bbox":{"left":0.117647,"top":0.089031,"width":0.47910099999999994,"height":0.04586700000000002}},{"text":"Studies on Wound Healing and Antiulcer Activities of Extract of Aerial \n Parts of Phyllanthus niruri L. (Euphorbiaceae) \n 1C.O. Okoli, 1A.C. Ezike, 1P.A. Akah, 2S.O. Udegbunam, 1T.C. Okoye, \n 1T.P. Mbanu and 1E. Ugwu \n 1Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, \n University of Nigeria, Nsukka 410001, Enugu State, Nigeria \n 2Department of Veterinary Surgery, Faculty of Veterinary Medicine, \n University of Nigeria, Nsukka 410001, Enugu State, Nigeria","bbox":{"left":0.197058,"top":0.147061,"width":0.6056790000000001,"height":0.14761400000000002}},{"text":"Abstract: Problem statement: Phyllanthus niruri is widely used in many parts of the world to \n manage a wide range of diseases. As part of efforts to elucidate its pharmacological activities and \n hence medicinal potential, we studied the wound healing and antiulcer properties of extract of the \n aerial parts using experimentally-created wounds and ulcers in rodents. Approach: Wound healing \n effect was assessed using excision and dead space wound models while antiulcer activity was \n evaluated using indomethacin-, ethanol acid- and cold-restraint stress-induced ulcer models. \n Results: The extract (5,10%) significantly (p<0.05) reduced the wound diameter producing 90.9 and \n 93.7% wound contraction respectively on day 18 post wounding. It also reduced epithelialization time \n of excised wounds and increased the rate of wound closure, with WC50 of 8.7%. The extract (400 mg \n kg−1) also significantly (p<0.05) increased the weight of granuloma tissue. In antiulcer studies, the \n extract significantly (p<0.05) inhibited the development of ulcers induced by indomethacin and \n moderately inhibited ethanol acid-induced ulcer. It was, however, devoid of any such effect in cold- \n restraint stress-induced lesions at the doses used. Phytochemical analysis of the extract revealed the \n presence of alkaloids, saponins, tannins, flavonoids, reducing sugar, carbohydrates and glycosides. \n Conclusion: These findings indicate that constituents of aerial parts of P. niruri possess wound \n healing and antiulcer properties.","bbox":{"left":0.161762,"top":0.31191,"width":0.676586,"height":0.23541199999999995}},{"text":"Key words: Wound healing, antiulcer, Phyllanthus niruri","bbox":{"left":0.161762,"top":0.559788,"width":0.378633,"height":0.017530000000000046}},{"text":"INTRODUCTION","bbox":{"left":0.236078,"top":0.594144,"width":0.13055099999999997,"height":0.017417000000000016}},{"text":"Phyllanthus niruri L. (Euphorbiaceae) is an annual \n and field weed widespread in temperate and tropical \n climates[1]. The morphology of the plant has been \n described[2]. It is popularly used in Asia, Africa and \n South America[3] as a stomachic, aperitive, \n antispasmodic, anti-hepatotoxic, antiviral, antibacterial, \n laxative, diuretic, carminative, in the management of \n diabetes, constipation, fever including malaria, \n jaundice, hepatitis B, dysentery, gonorrhea, syphilis, \n tuberculosis, cough, influenza, diarrhea, vaginitis, \n tumors, kidney stones[4-9]. Studies on extracts from \n various parts of the plant have revealed the \n antioxidant[10] and nitric oxide scavenging[11], \n antimalarial (antiplasmodial)[12-17], \n antihyperuricemic[18], analgesic[19,20], diuretic,","bbox":{"left":0.117647,"top":0.622818,"width":0.36773500000000003,"height":0.219958}},{"text":"hypotensive, hypoglycemic[21], hepatoprotective[4,22-27], \n hepatocurative[10], hypolipemic[28], nematicidal[29], \n platelet aggregation inhibitory[30], nephrolithiatic[31], \n HIV-1 reverse transcriptase inhibitory[23], HIV \n replication inhibitory[33], HIV/RRE binding \n inhibitory[34], urolithiatic[35-40] and vasorelaxant[1] \n activities. \n Several phytochemical constituents of this plant \n have been isolated and some were shown to be \n pharmacologically active. These include the alkaloids- \n 4-methoxy-securinine (Phyllanthine) and 4-methoxy- \n nor-securinine[41], arabinogalactan which stimulates \n superoxide anion production[3,42], ellagic acid, \n brevifolin carboxylic acid and ethyl brevifolin \n carboxylate with aldose reductase inhibitory effect[43], \n 1-O-galloyl-6-O-luteoyl-alpha-d-glucose with anti- \n babesial and antiplasmodial activities, beta-glucogallin,","bbox":{"left":0.514705,"top":0.592597,"width":0.36776200000000003,"height":0.25017899999999993}},{"text":"Corresponding Author: A.C. Ezike, Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, \n University of Nigeria, Nsukka 410001, Enugu State, Nigeria Tel: 2340852820538","bbox":{"left":0.117647,"top":0.85364,"width":0.7175910000000001,"height":0.02834100000000006}},{"text":"118","bbox":{"left":0.487647,"top":0.892667,"width":0.024592000000000003,"height":0.016776000000000013}}],"images_bbox":[],"images_bbox_not_text_overlap":[]}