{"content":[{"text":"the vertical bar and a box or diamond depicted \n the relative weight of the data.","bbox":{"left":0.570752,"top":0.046094,"width":0.3646269999999999,"height":0.034203000000000004}},{"text":"1. Randomized Controlled Trial \n (RCT) \n • Independent variable is controlled \n • Dependent variables are equal in the \n experimental and control groups through \n randomization \n • Blinded and double blinded \n • Crossover5 \n • p < 0.05, means statistical significance, with \n alpha < 5% \n • N reflects power with beta > 20% \n • Binary, use R2 \n • Continuous data, use co-variate analysis \n • Kaplan-Meier curve \n • Cox proportional hazard \n • Normal distribution curves \n • Bayesian method using Markov chain Monte \n Carlo","bbox":{"left":0.058987,"top":0.061543,"width":0.412037,"height":0.34930999999999995}},{"text":"3. Systematic Review \n • Literature review, often collating thousands of \n studies on a given topic \n • Cochran Review, done by experts in their field \n and often governed by medical institutions \n • Often the basis of the practice of evidence- \n based medicine, ie, there is not a RCT on \n every topic of interest, so a topic is reviewed \n by experts who read the literature and practice \n in their field of interest to bring experience and \n practical knowledge to bear.","bbox":{"left":0.511928,"top":0.453841,"width":0.4289799999999999,"height":0.20852699999999996}},{"text":"2. Meta-analysis \n • Multiple studies are combined, which often \n have varied study designs \n • Weighted averages \n • Pooled data \n • Combined statistical power is greater than that \n of any one study \n • Data depicted on Forrest Plots, with a line \n indicating 0 with data falling to the right or left \n of this line indicating benefit or no benefit. CI \n are depicted as bars that may or may not cross","bbox":{"left":0.058987,"top":0.683639,"width":0.428487,"height":0.21143100000000004}},{"text":"4. Expert Recommendations and \n Guidelines \n • Advisory Committee on Immunization \n Practices (ACIP): Human Papillomavirus \n testing in teenagers and young adults. \n • American Association of Clinical \n Endocrinologists (AACE): Diabetes \n management \n • American College of Cardiology (ACC) and \n American Heart Association (AHA): Blood \n Pressure treatment, Statin drugs in primary \n prevention of Coronary Artery Disease","bbox":{"left":0.511928,"top":0.678462,"width":0.407686,"height":0.23175999999999997}}],"images_bbox":[{"left":0.077451,"top":0.434849,"width":0.401797,"height":0.215278},{"left":0.55,"top":0.126263,"width":0.238399,"height":0.289394}],"images_bbox_not_text_overlap":[{"left":0.077451,"top":0.434849,"width":0.401797,"height":0.215278},{"left":0.55,"top":0.126263,"width":0.238399,"height":0.289394}]}