{"content":[{"text":"International Journal of Applied Ayurved Research ISSN: 2347- 6362 \n A CLINICAL STUDY TO EVALUATE THE EFFECT OF NAVAKA \n GUGGUL ON HYPERCHOLESTEROLEMIA- A SINGLE BLINDED \n PLACEBO CONTROLLED RANDOMIZED STUDY \n 1Agrawal Satish 2Pol Hemant 3Pawar Shivaji 4Dwivedi Ramakant \n 1Professor, PG Department of Kayachikitsa , Shubhdeep Ayurved Medical College & Hos- \n pital, Khandwa Road, Indore -452020 \n 2,3Associate Professor, PG Department of Samhita Siddhant, Shubhdeep Ayurved Medical \n College & Hospital, Khandwa Road, Indore -452020 \n 4Assistant Professor, PG Department of Kayachikitsa, Shubhdeep Ayurved Medical College \n & Hospital, Khandwa Road, Indore -452020 \n ABSTRACT : \n The plasma level of lipids is indicative of not only the severity of various co-morbid condi- \n tions such as Diabetes mellitus but also reflects the inherent genetic characteristic, lifestyle \n and food habits of an individual. A high level of Cholesterol is of prime concern as it is the \n solo risk factor for atherogenic diseases. The present study has been planned and carried out \n to evaluate the efficacy of Navaka guggul in the management of high cholesterol. \n After thorough review of both ancient and modern literatures, hypercholesterolemia can well \n be correlated with Poshaka (asthayi) meda vriddhi which is related to Kaphaj vikar in \n Ayurvedic system.Finally it can be concluded that the drug under study has shown enthusias- \n tic results in reducing the overall value of serum Cholesterol. 40% patients showed good ef- \n fect, 50% showed moderate effect and approximately 3% showed mild effect. \n Key words: Cholesterol, Kaphaj Vikar, Navaka Guggul, Meda vriddhi \n What's already known about this topic?: Various data from clinical and experimental \n studies have shown the relation between hyperlipidaemia and atherosclerotic diseases. Till \n date very little data is available on the effect of Navak Guggul on cholesterol levels. \n What does this study add?: The drug under trial has shown highly promising results in \n treating hypercholesterolemia, which should be further be evaluated on larger subjects. It has \n also opened the way for treatment of other kaphaj diseases which are result of deleterious \n food & lifestyle habits of modern society. \n INTRODUCTION:Multiple facts from group of heterogenous metabolically active \n clinical, experimental and epidemiological substances, continuously circulating in \n studies have proved the relationship be- plasma in form of lipoproteins to accom- \n tween hyperlipidaemia and atherosclerotic plish various important biological func- \n diseases such as Coronary artery disease, tions in addition to serve as major source \n cerebral stroke and Peripheral vascular of energy. They exist in a state of dynamic \n disease. The plasma level of lipids are in- equilibrium between peripheral tissues, \n dicative of not only the severity of various gastrointestinal tract and liver. According \n co-morbid conditions such as Diabetes to their physical properties, they have \n mellitus, Renal diseases or Hepatic mal- been grouped into Phospholipids, Choles- \n functioning but also reflects the inherent terol, Free fatty acids and Triglycerides. Of \n genetic characteristic, lifestyle and food all the four types, high level of Cholesterol \n habits of an individual.Lipids are basically is of clinical concern as it is the independ-","bbox":{"left":0.120984,"top":0.084072,"width":0.758335,"height":0.8251219999999999}}],"images_bbox":[{"left":0.43884,"top":0.030232,"width":0.089029,"height":0.053659}],"images_bbox_not_text_overlap":[{"left":0.43884,"top":0.030232,"width":0.089029,"height":0.053659}]}