{"content":[{"text":"0. Listen to intro on ligand optimization \n (optional) Dr. Chris Ho, the author of RACHEL, maintains a web page with a good discussion of receptor- \n based design technology. If you want more info, or if you are unclear on the terms and technologies in these \n tutorials, go to: http://www.newdrugdesign.com/Technology.html .","bbox":{"left":0.058824,"top":0.059939,"width":0.854184,"height":0.07294}},{"text":"1. Launch SYBYL, set up your RACHEL demo environment \n i) Open a Terminal shell, it will become your SYBYL terminal. To launch SYBYL: \n (create a new directory for this project, and navigate there) \n trigo -shell sybyl8.1 \n sybyl","bbox":{"left":0.058824,"top":0.182098,"width":0.6777310000000001,"height":0.090697}},{"text":"ii) You need to setup the files required for RACHEL. In the SYBYL shell: \n sh cp -r $TA_DEMO/rachel . (include the space and period) \n sh chmod -R +w rachel \n sh cp -R rachel/DBASE /tmp/","bbox":{"left":0.073529,"top":0.286129,"width":0.617873,"height":0.07378699999999999}},{"text":"2. Do the RACHEL tutorials. \n Tripos Bookshelf > RACHEL (middle left) > RACHEL Tutorials \n You should do all four sub-tutorials: \n RACHEL: \n Create a RACHEL Project \n RACHEL scoring functions \n Run a RACHEL Combinatorial Search \n Using Chemical Templates and Descriptors","bbox":{"left":0.058824,"top":0.408424,"width":0.52458,"height":0.142235}},{"text":"(You don't need to do the CHARLIE or Component Creation tutorials today).","bbox":{"left":0.083333,"top":0.56703,"width":0.6054160000000001,"height":0.01849999999999996}},{"text":"2","bbox":{"left":0.931373,"top":0.934803,"width":0.009804000000000035,"height":0.020212000000000008}}],"images_bbox":[],"images_bbox_not_text_overlap":[]}