{"content":[{"text":"FACT \n Sheet","bbox":{"left":0.640196,"top":0.0825,"width":0.27313600000000005,"height":0.062455}},{"text":"Recombinant Herpes Viral Vectors","bbox":{"left":0.328235,"top":0.18428,"width":0.34051000000000003,"height":0.017726999999999993}},{"text":"The following provides information on the use and containment of recombinant herpes viral vectors. \n Investigators should use these guidelines as part of their risk assessment when planning experiments \n with these vectors and preparing applications to the Institutional Biosafety Committee (IBC). Note the \n listed containment levels are the minimum that should be employed with these vectors: some \n experiments, such as the expression of toxins or oncogenes, may require higher levels of containment. \n The appropriateness of the containment should be considered as part of the investigator’s risk \n assessment and will be reviewed by the IBC.","bbox":{"left":0.078431,"top":0.224697,"width":0.81632,"height":0.143031}},{"text":"NIH Risk Group","bbox":{"left":0.082353,"top":0.381515,"width":0.12365700000000003,"height":0.015151999999999999}},{"text":"RG2 \n Herpesviruses are enveloped, icosahedral, double-stranded linear DNA \n viruses.","bbox":{"left":0.28902,"top":0.381515,"width":0.5640879999999999,"height":0.057728}},{"text":"Biocontainment Level \n Infectious to \n Humans/Animals \n Route of Transmission","bbox":{"left":0.082353,"top":0.462273,"width":0.18150500000000003,"height":0.08015200000000006}},{"text":"BSL-2 \n Yes","bbox":{"left":0.28902,"top":0.462273,"width":0.04386000000000001,"height":0.03697}},{"text":"HSV-1 is typically transmitted by saliva or by the infection on hands of \n healthcare personnel. HSV-2 is typically transmitted through sexual contact. \n HSV can be transmitted by direct contact with epithelial or mucosal surfaces. \n In the laboratory, HSV can be transmitted by ingestion, parenteral injection, \n droplet exposure of the mucous membranes (eyes, nose or mouth), and \n inhalation of aerosolized materials. \n Depends on type: \n • \n Oral Herpes \n • \n Genital Warts \n • \n Herpes esophagitis \n • \n Herpes encephalitis or meningitis \n Antivirals may reduce shedding \n After infection, the viruses are transported along sensory nerves to the nerve \n cell bodies, where they reside lifelong. Causes of recurrence may include: \n decreased immune function, stress, and sunlight exposure. The first episode \n is often more severe and may be associated with fever, muscle pains, swollen \n lymph nodes and headaches. Over time, episodes of active disease decrease \n in frequency and severity","bbox":{"left":0.28902,"top":0.527273,"width":0.6173580000000001,"height":0.3824240000000001}},{"text":"Laboratory Hazards","bbox":{"left":0.082353,"top":0.591667,"width":0.158802,"height":0.015152000000000054}},{"text":"Disease","bbox":{"left":0.082353,"top":0.656212,"width":0.062224000000000015,"height":0.015152000000000054}},{"text":"Treatment/Prophylaxis \n Pathogenesis","bbox":{"left":0.082353,"top":0.766364,"width":0.189193,"height":0.03712099999999996}}],"images_bbox":[{"left":0.049101,"top":0.064331,"width":0.442212,"height":0.048422}],"images_bbox_not_text_overlap":[{"left":0.049101,"top":0.064331,"width":0.442212,"height":0.048422}]}