{"content":[{"text":"The Oxygen Advantage","bbox":{"left":0.392571,"top":0.092332,"width":0.217962,"height":0.016926999999999998}},{"text":"Patrick McKeown","bbox":{"left":0.420365,"top":0.124757,"width":0.162381,"height":0.016926999999999998}},{"text":"Intro: The Basic Idea","bbox":{"left":0.1192,"top":0.189605,"width":0.192806,"height":0.016926999999999998}},{"text":"Patrick McKeown tells the story about how he had asthma for many years. His life \n changed when he came across the work of a Russian physician named Konstantin \n Buteyko. Using Buteyko’s ideas, he cleared up his asthma and went on to study with Dr. \n Buteyko.","bbox":{"left":0.1192,"top":0.222029,"width":0.762987,"height":0.076927}},{"text":"Much of this book is built around one basic principle. Oxygen is carried on hemoglobin \n after having been picked up in the lungs. The amount of oxygen in the blood is known \n as oxygen saturation, easily measured with a pulse oximeter. What is not generally \n known is that for the oxygen to be released from the hemoglobin, there must be enough \n carbon dioxide (CO2) present.","bbox":{"left":0.1192,"top":0.308696,"width":0.759821,"height":0.09735099999999997}},{"text":"If CO2 is in short supply from over-breathing, oxygen will not be released as readily. \n This is known as the Bohr Effect, named after Christian Bohr, an early 20th century \n physiologist who discovered that there must be adequate levels of CO2 for oxygen to be \n released from the hemoglobin. This piece is critical to understanding the principles in \n this book.","bbox":{"left":0.1192,"top":0.41506,"width":0.760491,"height":0.09692699999999999}},{"text":"The Effects of Low Carbon Dioxide \n Hypocapnia is a term used when there is not enough CO2. Overbreathing over time will \n make CO2 receptors in the brain regulatory centers overly-sensitive to increased levels \n of CO2 such that normal levels are met with a sense of air hunger and a feeling of \n breathlessness. Excessive sighing and feeling short-of-breath are often signs of a \n problem with low CO2.","bbox":{"left":0.1192,"top":0.545363,"width":0.7538900000000001,"height":0.1212899999999999}},{"text":"CO2 helps offload oxygen into the tissues that need it, helps increase dilation of smooth \n muscles in the walls of airways and blood vessels, and helps regulate pH. Excess \n breathing decreases blood vessel diameter by 50%, with blood flow decreasing by a \n factor of 4.","bbox":{"left":0.1192,"top":0.675666,"width":0.7590250000000001,"height":0.07662400000000003}},{"text":"You may see a state of exhaustion in people who talk a lot. They essentially blow off too \n much CO2 and end up tired from a lack of offloading of oxygen in the tissues.","bbox":{"left":0.1192,"top":0.762029,"width":0.763062,"height":0.03735100000000002}}],"images_bbox":[],"images_bbox_not_text_overlap":[]}