Who is at highest risk for Autoimmune polyendocrine syndrome ?
Genetics play a role in the likelihood someone may have Autoimmune polyendocrine syndrome.
Type I has been linked to a genetic defect in the 21st chromosome which influences immune tolerance. Type II patients are at a higher risk when they carry a particular HLA genotype. Type III has been linked to an X chromosome defect and is more common in males. Women, too, can be carriers and might suffer mildly from the disease. </s>