(Attachment)  
 
Designation of Shitei Yakubutsu  (designated substances) based on the Act on 
Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and 
Medical Devices  (1960, Law No.145)  
 
In order to prevent the abuse of substances with probable effects on the central nervous 
system and to clarify the regulation under the Act on Securing Quality, Efficacy and 
Safety of Products Including Pharmaceuticals and Medical Devices  (hereinafter referred 
to as the Act ), the Minister of Health, Labour and Welfare of Japan proposes to 
additionally designa te the following substances as Shitei Yakubu tsu (designated 
substances). Manufacture, import, sale, s imple ownership and the use of designated 
substances  are bann ed except for the proper uses  (see below).  
 
● The proposed substances as Shitei Yakubutsu   
*Abbreviation is put in parentheses.  
 
3 substances  
1. N-(1-Amino -3,3-dimethyl -1-oxobutan -2-yl)-1-benzyl -1H-indazole -3- 
carboxamide  
［ADB -BINACA ］ 
2.   2-(Ethylamino) -2-(3-fluorophenyl)cyclohexanone  
［FXE , Fluorexetamine ］ 
3.   2-(Butylamino) -1-(3,4-methylenedioxyphenyl)butan -1-one 
［N-Butyl butylone］ 
 
2 substance groups  
1.  Any compounds in which a linear alkyl group (the number of carbon atoms is 
limited from 3 to 8) is bonded to the 3 -position and no further substituents are 
attached other than at the 1 -, 3-, 6-, and 9 -positions of 6a,7,8,10a -tetrahydro -
6,6,9 -trimethyl -6H-dibenzo[ b,d]pyran -1-ol, and salts of these compounds. 
Except in the case of narcotics as defined in the Narcotics and Psychotropics 
Control Law.  
O ROH
 
R= n-C3H7, n-C4H9, n-C5H11※, n-C6H13, n-C7H15, n-C8H17 
                   ※n-C5H11: Narcotic ( Δ9-THC)  2. Any compounds in which a linear alkyl group (the number of carbon atoms is 
limited from 3 to 8) is bonded to the 3 -position and no further substituents are 
attached other than at the 1 -, 3-, 6-, and 9 -positions of 6a,7,10,10a -tetrahydro -
6,6,9 -trimethyl -6H-dibenzo[ b,d]pyran -1-ol, and salts of these compounds. 
Except in the case of narcotics as defined in the Narcotics and Psychotropics 
Control Law.   
O ROH
 
 
R= n-C3H7, n-C4H9, n-C5H11※, n-C6H13, n-C7H15, n-C8H17 
                 ※n-C5H11: Narcotic ( Δ8-THC)  
 
 
 
● The propos ed proper uses for the above Shitei Yakubutsu  are; 
1.  To be used for researches  or tests at the government, the local governments, agencies 
thereof, technical colleges, inter -university research institutes,  the independent 
administrative agencies and the local independent administrative agencies  
2.  To be used for tests under the Ac t, and  
3.  To be used for forensic use  