 
EN   EN 
 
 
 EUROPEAN  
COMMISSION   
Brussels, XXX   
SANE/10413/2015 ANNEX  
(POOL/E2/2015/10413/10413 -EN 
ANNEX.doc) D061419/02  
[…](2019) XXX  draft  
ANNEX  
 
ANNEX  
to the  
COMMISSION REGULATION (EU) …/...  
on reference points for action for non -allowed pharmacologically active substances 
present in food of animal origin  and repealing Decision 2005/34/EC.    
EN 1  EN ANNEX  
Reference points for action (RPA)  
Substance  RPA  
(µg/kg)  Other provisions  
Chloramphenicol  0.15  
Malachite green  0.5 0.5 µg/kg for the s um of malachite green and 
leucomalachite green  
Nitrofurans and 
their metabolites  0.51 0.5 µg/kg for each of the metabolites of furazolidone (AOZ 
or 3-amino -2-oxazolidinone ), furaltadone (AMOZ or 3 -
amino -5-methylmorpholino -2-oxazolidinone), 
nitrofurantoin (AHD or 1 -aminohydantoin), nitrofurazone 
(SEM or semicarbazide) and nifursol (DNSH or 3,5-
dinitrosalicylic acid hydrazide)  
 
                                                 
1 Due to the natural occurrence of SEM in crayfish at levels above the RPA, only levels of AOZ, AMOZ, 
ADH and DNSH above the RPA are a clear indication of the illegal use of nit rofurans and their 
metabolites. The RPA of 0.5 µg/kg for SEM in crayfish shall only be applied, when the illegal use of 
nitrofurazone on crayfish has been established.  