section_path: History/Descendants in later Persian dynasties
section_name: Descendants in later Persian dynasties
paragraph_text: Descendants in later Persian dynasties
  
  Several later Persian rulers, forming the Frataraka dynasty, are known to have acted as representatives of the Seleucids in the region of Fārs. They ruled from the end of the 3rd century BC to the beginning of the 2nd century BC, and Vahbarz or Vādfradād I obtained independence c. 150 BC, when Seleucid power waned in the areas of southwestern Persia and the Persian Gulf region.
  
  During an apparent transitional period, corresponding to the reigns of Vādfradād II and another uncertain king, no titles of authority appeared on the reverse of their coins. The earlier title prtrk' zy alhaya (Frataraka) had disappeared. Under Dārēv I (Darios I) however, the new title of mlk, or king, appeared, sometimes with the mention of prs (Persis), suggesting that the kings of Persis had become independent rulers.
  
  When the Parthian Arsacid king Mithridates I (c. 171–138 BC) took control of Persis, he left the Persian dynasts in office, known as the Kings of Persis, and they were allowed to continue minting coins with the title of mlk ("King").
  
  With the reign of Šābuhr, the son of Pāpag, the kingdom of Persis then became a part of the Sasanian Empire. Šābuhr's brother and successor, Ardaxšir (Artaxerxes) V, defeated the last legitimate Parthian king, Artabanos V in 224 AD, and was crowned at Ctesiphon as Ardaxšir I (Ardashir I), šāhanšāh ī Ērān, becoming the first king of the new Sasanian Empire.
  
  The Achaemenid line would also be carried on through the Kingdom of Pontus, based in the Pontus region of northern Asia Minor. This Pontic Kingdom, a state of Persian origin, may even have been directly related to Darius I and the Achaemenid dynasty. It was founded by Mithridates I in 281 BC and lasted until its conquest by the Roman Republic in 63 BC. The kingdom grew to its largest extent under Mithridates VI the Great, who conquered Colchis, Cappadocia, Bithynia, the Greek colonies of the Tauric Chersonesos and for a brief time the Roman province of Asia. Thus, this Persian dynasty managed to survive and prosper in the Hellenistic world while the main Persian Empire had fallen. Despite Greek influence on the Kingdom of Pontus, Pontics continued to maintain their Achaemenid lineage.
  
  Both the later dynasties of the Parthians and Sasanians would on occasion claim Achaemenid descent. Recently there has been some corroboration for the Parthian claim to Achaemenid ancestry via the possibility of an inherited disease (neurofibromatosis) demonstrated by the physical descriptions of rulers and from the evidence of familial disease on ancient coinage.