section_path: Biology/Toxicity
section_name: Toxicity
paragraph_text: Toxicity
  
  Aluminium is classified as a non-carcinogen by the United States Department of Health and Human Services. A review published in 1988 said that there was little evidence that normal exposure to aluminium presents a risk to healthy adult, and a 2014 multi-element toxicology review was unable to find deleterious effects of aluminium consumed in amounts not greater than 40 mg/day per kg of body mass. Most aluminium consumed will leave the body in feces; most of the small part of it that enters the bloodstream, will be excreted via urine; nevertheless some aluminium does pass the blood-brain barrier and is lodged preferentially in the brains of Alzheimer's patients. Evidence published in 1989 indicates that, for Alzheimer's patients, aluminium may act by electrostatically crosslinking proteins, thus down-regulating genes in the superior temporal gyrus.