section_path: Prognosis and risk factors/Genetic risk factors
section_name: Genetic risk factors
paragraph_text: Genetic risk factors
  
  Genetics plays an important role in the ability to fight off Covid. For instance, those that do not produce detectable type I interferons or produce auto-antibodies against these may get much sicker from COVID‑19. Genetic screening is able to detect interferon effector genes. Some genetic variants are risk factors in specific populations. For instance, an allele of the DOCK2 gene (dedicator of cytokinesis 2 gene) is a common risk factor in Asian populations but much less common in Europe. The mutation leads to lower expression of DOCK2 especially in younger people with severe COVID-19 infections. In fact, many other genes and genetic variants have been found that determine the outcome of SARS-CoV-2 infections.