section_path: Applications/Biology
section_name: Biology
paragraph_text: Biology
  
  Topology has been used to study various biological systems including molecules and nanostructure (e.g., membraneous objects). In particular, circuit topology and knot theory have been extensively applied to classify and compare the topology of folded proteins and nucleic acids. Circuit topology classifies folded molecular chains based on the pairwise arrangement of their intra-chain contacts and chain crossings. Knot theory, a branch of topology, is used in biology to study the effects of certain enzymes on DNA. These enzymes cut, twist, and reconnect the DNA, causing knotting with observable effects such as slower electrophoresis.