section_path: History/End of the Inca Empire
section_name: End of the Inca Empire
paragraph_text: End of the Inca Empire
  
  The Spanish installed Atahualpa's brother Manco Inca Yupanqui in power; for some time Manco cooperated with the Spanish while they fought to put down resistance in the north. Meanwhile, an associate of Pizarro, Diego de Almagro, attempted to claim Cusco. Manco tried to use this intra-Spanish feud to his advantage, recapturing Cusco in 1536, but the Spanish retook the city afterwards. Manco Inca then retreated to the mountains of Vilcabamba and established the small Neo-Inca State, where he and his successors ruled for another 36 years, sometimes raiding the Spanish or inciting revolts against them. In 1572 the last Inca stronghold was conquered and the last ruler, Túpac Amaru, Manco's son, was captured and executed. This ended resistance to the Spanish conquest under the political authority of the Inca state.
  
  After the fall of the Inca Empire many aspects of Inca culture were systematically destroyed, including their sophisticated farming system, known as the vertical archipelago model of agriculture. Spanish colonial officials used the Inca mita corvée labor system for colonial aims, sometimes brutally. One member of each family was forced to work in the gold and silver mines, the foremost of which was the titanic silver mine at Potosí. When a family member died, which would usually happen within a year or two, the family was required to send a replacement.
  
  Although smallpox is usually presumed to have spread through the Empire before the arrival of the Spaniards, the devastation is also consistent with other theories. Beginning in Colombia, smallpox spread rapidly before the Spanish invaders first arrived in the empire. The spread was probably aided by the efficient Inca road system. Smallpox was only the first epidemic. Other diseases, including a probable typhus outbreak in 1546, influenza and smallpox together in 1558, smallpox again in 1589, diphtheria in 1614, and measles in 1618, all ravaged the Inca people.
  
  There would be periodic attempts by indigenous leaders to expel the Spanish colonists and re-create the Inca Empire until the late 18th century. See Juan Santos Atahualpa and Túpac Amaru II.