Manchester City restored their six-point lead at the top of the Premier League as doubles from Kevin De Bruyne and Riyad Mahrez inspired the champions to a commanding 4-1 derby victory over Manchester United
De Bruyne got City off to the perfect start five minutes into the 187th Manchester derby, slotting home his 50th Premier League goal
Jadon Sancho, on his first Etihad Stadium appearance, provided temporary respite for United in the absence of the injured Cristiano Ronaldo with a well-taken equaliser midway through the first half, but De Bruyne's second ensured City led - deservedly - at the break
Mahrez brilliantly volleyed in City's third from a corner to wrap up the statement victory 22 minutes from time, and amid fever-pitch celebrations, the Algerian underscored the dominance of Pep Guardiola's side with a late, VAR-awarded fourth
City's victory sees them respond to Liverpool's title challenge and reinstate their six-point lead at the top of the Premier League, while a first defeat since January 3 - and second league defeat of Ralf Rangnick's reign - leaves United fifth, a point behind fourth-placed Arsenal having played three games more
After the game, Sky Sports'  while former United captain Roy Keane called it "shameful"
City's start was fast and emphatic, and United's plan was thrown out of the window inside five minutes, De Bruyne losing his marker Alex Telles and slotting past David de Gea after clinical link-up play between Jack Grealish and Bernardo Silva down the left flank
To their credit United kept their cool, and their faith in Ralf Rangnick's instructions, to prevent a City pile-on, and almost produced an immediate response, with only Ederson's smothering save preventing Fred from drawing the visitors level
And United hit back on 22 minutes, with Sancho silencing the City fans on his return to the Etihad with a clinical finish into the bottom corner after he collected Paul Pogba's intelligent cross-field switch and cutting inside Kyle Walker
That goal only seemed to poke the hornet's nest, and parity lasted a mere five minutes
 Phil Foden's wonderous flick over Victor Lindelof and low shot forced a save from De Gea, and from the ensuing melee where Silva tried to convert, the ball fell to De Bruyne to ram home his second
City could have been further ahead at the break or level, with Foden dragging a shot wide on the counter before Sancho blazed over from an identical position from which he had earlier scored
City's dominance was aided by a lethargic start to the second half from United, whose insistence in playing out from the back saw them contribute to their own problems
 And, after Foden, Mahrez and De Bruyne all had sights of the United goal, the pressure finally told
De Bruyne's beautifully-flighted corner found Mahrez on the edge of the box and, afforded time by an intelligent block from Rodri, he lashed in City's third in stunning fashion
Not content with their two-goal lead, City looked to add further salt into United wounds
 Joao Cancelo nearly did so in spectacular fashion, with De Gea thwarted his late bicycle kick, before a final blow was administered when Mahrez raced in behind, found the United net, and survived a marginal VAR check for offside to underlined the chasm between these Manchester rivals
"Manchester United's response to going 3-1 down has been embarrassing
 Ninety-two per cent possession for City? They have given up
"They were walking around the pitch
 It's nowhere near good enough
 There can be no complaints
 City have been absolutely outstanding
 But as a Manchester United fan, it's embarrassing
"City played brilliantly in the second half
 But the effort and intensity from United in the last 20 minutes was non-existent
 The scoreline isn't the problem
 It's the response to going 3-1 down that's the problem
 They have thrown the towel in
""United gave up and in a derby, in any game, it's unforgivable
 I can forgive mistakes, but not running back, not trying to tackle - there are players out there who shouldn't play for Manchester United again
"There is no hiding place in top-level sport
 We've all lost football matches but it's the way they've lost it
 You expect them surely to play with a bit of pride but that's a reflection of where the team is at the moment
"If you can't run back and put your body on the line when you're playing for Manchester United, it's shameful
" "We played a good, if not decent first half
 We were competitive
 Difficult to concede an early goal
 We came back, scored a brilliant goal ourselves then conceded another on the counter
 It was a very difficult game against one of the best teams in the world
 We conceded a fourth in the last minute of the game
 It is a difficult game that shows we have a long way to go to close that gap
"In the second half it [showed the gap between the two sides] but the first half was a competitive game
 Everyone knows how good they are
 They are one of the top teams in the world and there is a gap between the two teams
"We are fully aware we need to win games
 This is one of the most difficult
 It is accepting they were the better team today
 But we look ahead to the next games, and we need to win the next two home games - they are essential to us
""It was a good one, especially the second half
 It was one of the highest levels we have played in years
 In the first half they had more energy than the second half
 In the second half they struggled to press us as a consequence of the first half
"They played a 4-2-4 and were very aggressive for Ralf and without Cristiano Ronaldo they can do that
 They were incredibly impressive
 We struggled without build up
"In the first half we had more chances on the counter-attack rather than possession
 When we were in their half, we played really well but the problem we had was to arrive there, to get there and to drop the opponent in their half
"But in the second half we had more personality to play more in the lines and the movement from everyone was excellent
 Every decision we made in the game was good, that's why we won the game
"Kevin De Bruyne's opener for Manchester City (04:26) was his side's earliest Premier League goal in the Manchester derby since Edin Dzeko netted after 43 seconds at Old Trafford in March 2014
De Bruyne has had a direct hand in 89 goals in 100 home Premier League appearances (37 goals, 52 assists)
The Belgian international the fourth City player to net a brace against United on home soil in the competition after Niall Quinn (1993), Shaun Goater (2002) and Sergio Agüero (2013)
Man City host Sporting Lisbon in the second leg of their Champions League last-16 tie on Wednesday at 8pm, while Man Utd host Tottenham on at 5
30pm - live on 
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