Ten-man Celtic were dumped out of the Europa League in the round of 32 for the second season running as a 1-0 defeat confirmed a 3-0 aggregate victory for Valencia on Thursday
Celtic's hopes of overturning a two-goal first-leg deficit were dashed inside 36 minutes at the Mestalla when Jeremy Toljan was sent off for a second bookable offence
Valencia capitalised on their man advantage as substitute Kevin Gameiro scored the winner two minutes after coming off the bench
Celtic travelled to Valencia needing a first competitive win on Spanish soil to progress, and an assured start gave them hope of reaching the last 16
Kristoffer Ajer had two swipes at a chance inside ten minutes but blazed over from close range after his initial effort was blocked
Celtic contained Valencia in the opening 36 minutes, registering eight attempts on goal to the hosts' none
 But their positive start evaporated in an instant
Having tugged back on Goncalo Guedes ten minutes earlier, Toljan was given his marching orders after impeding the Portuguese as tried to run in behind
With the extra man, Valencia piled pressure on the Celtic goal before the interval but two sublime saves from Scott Bain to deny Dani Parejo and Santi Mina kept the hosts at bay
It was backs against the wall for Celtic in the second half, as Valencia attacked in waves at the start of the second period
 Jozo Simunovic cleared Mina's cross off his own goal line before Ruben Sobrino somehow failed to convert Daniel Wass' teasing cross from close range
Bain was well positioned to keep out Wass' looping volley before Celtic created their best chance of the game
 Ryan Christie's whipped free-kick from the left found Ajer free at the near post, but the centre-back fired a header over from six yards shortly after the hour mark
Celtic were made to pay as Gameiro sealed Valencia's progress on 69 minutes
 The Frenchman ghosted into space in the area and was on hand to stroke home from close range after Wass had headed Parejo's diagonal back into the six-yard box, ending Celtic's European adventure in the process
Celtic look to consolidate their eight-point lead at the top of the Scottish Premiership when they host Motherwell on Sunday (3pm GMT)
 Valencia also return to La Liga action on Sunday with a trip to Leganes (11am GMT)
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